PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27369375-0	2017	Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells.	usnic acid	44-54	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22	
32326366-1	2020	(+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma.	usnic acid	4-14	NFE2 like bZIP transcription factor 2	Homo sapiens	110-114	
27369375-3	2017	In this study, we investigated the role of oxidative stress and the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells.	usnic acid	94-104	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72	
27369375-6	2017	Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1).	usnic acid	32-42	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93	
27369375-6	2017	Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1).	usnic acid	32-42	NFE2 like bZIP transcription factor 2	Homo sapiens	95-138	
27369375-6	2017	Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1).	usnic acid	32-42	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154	
27369375-6	2017	Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1).	usnic acid	32-42	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154	
27369375-7	2017	Furthermore, knockdown of Nrf2 with shRNA potentiated usnic acid-induced DNA damage and cytotoxicity.	usnic acid	54-64	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30	
27369375-8	2017	Taken together, our results show that usnic acid causes cell cycle dysregulation, DNA damage, and oxidative stress and that the Nrf2 signaling pathway is activated in usnic acid-induced cytotoxicity.	usnic acid	167-177	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132	
33635505-0	2021	(+)-Usnic acid modulates the Nrf2-ARE pathway in FaDu hypopharyngeal carcinoma cells.	usnic acid	4-14	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33	
33635505-4	2021	Consequently, (+)-usnic acid enhanced the transcription and translation of Nrf2 target genes: NQO1, SOD, and to a lesser extent, GSTP.	usnic acid	18-28	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79	
33635505-5	2021	The treatment of FaDu cells with (+)-usnic acid decreased both GSK-3beta transcript and protein level, indicating its possible involvement in Nrf2 activation.	usnic acid	37-47	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146	
33635505-9	2021	In summary, the results of this study indicate that low concentrations of (+)-usnic acid activate Nrf2 transcription factor, most probably as a result of ROS accumulation, but do not lead to FaDu hypopharyngeal carcinoma cells death.	usnic acid	78-88	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102	
33635505-1	2021	Naturally occurring phytochemicals of different origin and structure, arctigenin, bergenin, usnic acid and xanthohumol, were shown to affect Nrf2 pathway in the context of various diseases, but their effect on this pathway in cancer cells was not extensively investigated.	usnic acid	92-102	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145