PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26367336-1	2016	Previously conducted studies revealed that smoking enhanced the efficacy of clopidogrel by increasing formation of the active metabolite (AM) from the prodrug through induction of the cytochrome CYP1A2.	Clopidogrel	76-87	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	195-201	
30422888-0	2018	Investigating the Effect of Demographics, Clinical Characteristics, and Polymorphism of MDR-1, CYP1A2, CYP3A4, and CYP3A5 on Clopidogrel Resistance.	Clopidogrel	125-136	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	95-101	
30911318-8	2019	Danshen inhibited carboxylesterase 1 and most enzyme of cytochrome P450, especially cytochrome P450 1A2, which may affect the metabolism of clopidogrel.	Clopidogrel	140-151	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	84-103	
22440495-2	2012	BACKGROUND: Cigarette smoking is an inducer of cytochrome P450 1A2, a hepatic enzyme involved in clopidogrel metabolism.	Clopidogrel	97-108	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	47-66	
24518848-3	2014	Most probably, this is due to induction of cytochrome p450 1A2 by smoking, which accelerates conversion of clopidogrel to its active metabolite.	Clopidogrel	107-118	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-62	
23591705-5	2013	The mechanism of the interaction between smoking status and clopidogrel efficacy remains unclear but may be mediated by cytochrome P450 (CYP)1A2.	Clopidogrel	60-71	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	120-144	
21095272-1	2010	BACKGROUND: Smoking induces CYP1A2, thereby enhancing clopidogrel conversion to its active metabolite.	Clopidogrel	54-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	28-34	
25083217-4	2011	There is agreement amongst in vitro studies regarding the involvement of CYP1A2 and CYP2B6 in the metabolism of clopidogrel to 2-oxo-clopidogrel.	Clopidogrel	112-123	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	73-79	
21884870-1	2011	BACKGROUND: Pharmacodynamic studies reported an amplified on-clopidogrel platelet inhibition in smokers potentially caused by an increased metabolic drug activation via induction of cytochrome P450 1A2.	Clopidogrel	61-72	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	182-201	
21148426-0	2011	Enhanced clopidogrel responsiveness in smokers: smokers" paradox is dependent on cytochrome P450 CYP1A2 status.	Clopidogrel	9-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	97-103	
21148426-10	2011	CONCLUSIONS: Enhanced clopidogrel response in smokers, known as the smokers" paradox, is not universal but was observed only in cytochrome P450 CYP1A2 (-163C>A) A-allele carriers, suggesting a genotype-dependent effect of smoking on clopidogrel responsiveness.	Clopidogrel	22-33	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	144-150	
21148426-10	2011	CONCLUSIONS: Enhanced clopidogrel response in smokers, known as the smokers" paradox, is not universal but was observed only in cytochrome P450 CYP1A2 (-163C>A) A-allele carriers, suggesting a genotype-dependent effect of smoking on clopidogrel responsiveness.	Clopidogrel	236-247	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	144-150	
19636246-5	2010	Polymorphisms in the hepatic enzymes involved in the metabolism of clopidogrel (e.g., CYP 1A2, CYP3A4, CYP2C19) or within the platelet membrane receptor (P2Y12) and/or polymorphism of platelet integrin alphaIIbbeta3 or integrin alpha2beta1 may affect platelet responses and could influence response to clopidogrel administration.	Clopidogrel	67-78	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	86-93	
20942779-10	2010	Several studies have also demonstrated that CYP3A4/5 and CYP1A2 are important in clopidogrel bioactivation and should also be considered as potential targets for unwanted drug-drug interactions.	Clopidogrel	81-92	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63	
18474675-2	2008	Mechanism-based CYP2B6 inhibitors (i.e., clopidogrel, ticlopidine, and triethylenethiophoramide) significantly inhibited the formation of M1 from sibutramine and M2 from M1, respectively; in contrast, no effect was observed when using potent inhibitors of eight P450 isozymes (CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A).	Clopidogrel	41-52	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	277-283	
16772608-2	2006	To determine whether frequent functional variants of genes coding for candidate cytochrome P450 (CYP) isoenzymes involved in clopidogrel metabolic activation (CYP2C19*2, CYP2B6*5, CYP1A2*1F, and CYP3A5*3 variants) influence the platelet responsiveness to clopidogrel, we conducted a prospective pharmacogenetic study in 28 healthy white male volunteers treated for 7 days with clopidogrel 75 mg/d.	Clopidogrel	125-136	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	180-186	
33931001-3	2021	In contrast, carriers of CYP2C19*17, CYP3A4*1G, and CYP1A2*1F alleles showed a more significant antiplatelet effect in clopidogrel users and expected to have a protective role as a genetic factor against cardiovascular events.	Clopidogrel	119-130	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	52-58	
19704027-8	2009	The oxidation of clopidogrel to its thiolactone metabolite correlated with variable activities of CYP1A2, CYP2B6, and CYP2C19.	Clopidogrel	17-28	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	98-104	
19358940-2	2009	BACKGROUND: Cigarette smoking induces cytochrome P450 (CYP)1A2, which converts clopidogrel into its active metabolite, and prior studies suggest greater inhibition of platelet aggregation by clopidogrel in smokers of > or =10 cigarettes/day.	Clopidogrel	79-90	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	38-62	
19358940-2	2009	BACKGROUND: Cigarette smoking induces cytochrome P450 (CYP)1A2, which converts clopidogrel into its active metabolite, and prior studies suggest greater inhibition of platelet aggregation by clopidogrel in smokers of > or =10 cigarettes/day.	Clopidogrel	191-202	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	38-62	
18687246-3	2008	Clopidogrel is metabolically activated by several hepatic cytochrome P450 (CYP) isoenzymes, including CYP1A2.	Clopidogrel	0-11	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	102-108	
18687246-4	2008	Cigarette smoking induces CYP1A2 and may, therefore, enhance the conversion of clopidogrel to its active metabolite.	Clopidogrel	79-90	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	26-32	
17361128-3	2007	Clopidogrel"s activation involves two sequential steps by CYP3A, CYP1A2, CYP2C9, CYP2C19, and/or CYP2B6.	Clopidogrel	0-11	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	65-71	
31556777-6	2020	In the clopidogrel subgroup, homozygous carriers (AA) of the CYP1A2*1F gene (rs762551, 163C>A) appeared more frequently in smokers than in nonsmokers (45.6% vs 32.7%, p = .035).	Clopidogrel	7-18	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	61-67