PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33187816-9	2021	Oxycodone upregulated the expression of claudin-5, ZO-1, AQP1, and AQP5 but downregulated the expression of TNF-alpha, IL-1beta, TLR4, NF-kappaB, MMP9, and caspase-3 and suppressed endothelial apoptosis in vivo and in vitro.	Oxycodone	0-9	tumor necrosis factor	Rattus norvegicus	108-117	
31895751-6	2020	Oxycodone also decreased both the mRNA and protein expression levels of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta.	Oxycodone	0-9	tumor necrosis factor	Rattus norvegicus	98-125	
31895751-6	2020	Oxycodone also decreased both the mRNA and protein expression levels of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta.	Oxycodone	0-9	tumor necrosis factor	Rattus norvegicus	127-136	
29950892-7	2018	Oxycodone at 50 and 100 ng/mL could significantly suppress LPS-induced production of TNF-alpha and IL-1beta and the expression of TNF-alphamRNA, IL-1betamRNA, and TGF-beta1/smad2/3 signaling pathway.	Oxycodone	0-9	tumor necrosis factor	Rattus norvegicus	85-94	
27562050-7	2016	Moreover, oxycodone decreased the productions of the inflammatory cytokines including IL-1beta, TNF-alpha, HMGB-1((1 208+-18)pg/ml, (1 660+-14) pg/ml, (61+-4) pg/ml , all P<0.05).	Oxycodone	10-19	tumor necrosis factor	Rattus norvegicus	96-105