PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19519662-5 2009 Our results demonstrate that receptor-internalizing agonists (like DAMGO, beta-endorphin, methadone, piritramide, fentanyl, sufentanil, and etonitazene) strongly induce NADH/NADPH-mediated ROS synthesis via PLD-dependent signaling pathways, whereas agonists that do not induce MOPr endocytosis and PLD2 activation (like morphine, buprenorphine, hydromorphone, and oxycodone) failed to activate ROS synthesis in transfected human embryonic kidney 293 cells. Oxycodone 364-373 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 207-210