PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32572934-6 2020 RESULTS: Immunohistochemistry results showed that compared with those in the sham operation group, the positive expression of BAX was remarkably increased (p<0.05), while that of Bcl-2 was significantly decreased (p<0.05) in the model group, oxycodone group, and inhibitor group. Oxycodone 242-251 BCL2 associated X, apoptosis regulator Rattus norvegicus 126-129 32797768-5 2020 From the molecular mechanism, it was evident that oxycodone not only decreased the expression levels of Bax, active-caspase 3 protein but also increased the expression levels of Bcl2, p-PI3K, and p-Akt protein in heart tissue of the I/R rats. Oxycodone 50-59 BCL2 associated X, apoptosis regulator Rattus norvegicus 104-107 32572934-7 2020 Compared with the model group, oxycodone group and inhibitor group had an evidently reduced positive expression of BAX (p<0.05) and an evidently raised positive expression of Bcl-2 (p<0.05). Oxycodone 31-40 BCL2 associated X, apoptosis regulator Rattus norvegicus 115-118 32572934-12 2020 Moreover, it was discovered from qRT-PCR results that compared with those in the sham operation group, the mRNA expression of BAX was markedly raised (p<0.05), whereas that of Bcl-2 was decreased predominantly (p<0.05) in the model group, oxycodone group, and inhibitor group. Oxycodone 239-248 BCL2 associated X, apoptosis regulator Rattus norvegicus 126-129 32572934-13 2020 Compared with the model group, oxycodone group, and inhibitor group had an evidently reduced mRNA expression of BAX (p<0.05) and a significantly raised mRNA expression of Bcl-2 (p<0.05). Oxycodone 31-40 BCL2 associated X, apoptosis regulator Rattus norvegicus 112-115 31276638-5 2019 Possible mechanisms might involve the regulatory effect of oxycodone on the MAPK-Bcl2/Bax-caspase-9-caspase-3 pathway, as well as its inhibitory effect on cellular reactive oxygen species (ROS) production and mitochondrial membrane potential activation. Oxycodone 59-68 BCL2 associated X, apoptosis regulator Rattus norvegicus 86-89