PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22895704-6	2012	Importantly, opioid-TLR4 actions are not a unidirectional influence on opioid pharmacodynamics, since TLR4(-/-) mice had reduced oxycodone-induced p38 and JNK phosphorylation, while displaying potentiated analgesia.	Oxycodone	129-138	toll-like receptor 4	Mus musculus	20-24	
22895704-6	2012	Importantly, opioid-TLR4 actions are not a unidirectional influence on opioid pharmacodynamics, since TLR4(-/-) mice had reduced oxycodone-induced p38 and JNK phosphorylation, while displaying potentiated analgesia.	Oxycodone	129-138	toll-like receptor 4	Mus musculus	102-106	
24797666-8	2014	The immunogenicity of oxycodone vaccines may be modulated by TLR4 signaling since responses to 6OXY-nKLH in alum were decreased in TLR4-deficient mice.	Oxycodone	22-31	toll-like receptor 4	Mus musculus	61-65	
34625874-8	2022	Compared with I/R group, Dex and Oxy treatment down-regulated the expression of NF-kappaB, TLR4, TNF-alpha and CD68 (all p < 0.05), while no significantly different was found in CD206 and IL-10.	Oxycodone	33-36	toll-like receptor 4	Mus musculus	91-95	
34625874-12	2022	Both Dex and Oxy could alleviate the inflammatory response likely by inhibiting the polarization of microglia toward M1 phenotype via TLR4/NF-kappaB pathway.	Oxycodone	13-16	toll-like receptor 4	Mus musculus	134-138