PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20487198-0 2010 Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2. Oxycodone 27-36 glutathione S-transferase alpha 5 Rattus norvegicus 195-201 20487198-7 2010 KEY FINDINGS: The expression of several drug metabolising enzymes was modulated by oxycodone treatment: cytochrome P450 (CYP) 2B2, CYP2C13, CYP17A1, epoxide hydrolase 2, carboxylesterase 2, flavin-containing monooxygenase 1, glutathione S-transferase alpha 5 (rGSTA5) and CYP3A2. Oxycodone 83-92 glutathione S-transferase alpha 5 Rattus norvegicus 225-258 20487198-7 2010 KEY FINDINGS: The expression of several drug metabolising enzymes was modulated by oxycodone treatment: cytochrome P450 (CYP) 2B2, CYP2C13, CYP17A1, epoxide hydrolase 2, carboxylesterase 2, flavin-containing monooxygenase 1, glutathione S-transferase alpha 5 (rGSTA5) and CYP3A2. Oxycodone 83-92 glutathione S-transferase alpha 5 Rattus norvegicus 260-266 20487198-12 2010 CONCLUSIONS: Repeated oxycodone administration is associated with a significant up-regulation of rGSTA5 and concomitant down-regulation of CYP3A2 mRNA, protein expression and functionality. Oxycodone 22-31 glutathione S-transferase alpha 5 Rattus norvegicus 97-103