PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19903862-9 2010 The proliferative response to high glucose and hexosamine flux is rapamycin-sensitive, suggesting that this effect is associated with signaling through rapamycin-sensitive mTOR complex 1 (mTORC1). Hexosamines 47-57 mechanistic target of rapamycin kinase Homo sapiens 172-176 30356686-1 2018 The hexosamine biosynthetic pathway (HBP) and the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway are considered as nutrient sensors that regulate several essential biological processes. Hexosamines 4-14 mechanistic target of rapamycin kinase Homo sapiens 122-126 33744394-1 2021 Hexosamine biosynthetic (HBP) and PI3K/AKT/mTOR pathways are found to predominate the proliferation and survival of prostate cancer cells. Hexosamines 0-10 mechanistic target of rapamycin kinase Homo sapiens 43-47 15001544-0 2004 Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells. Hexosamines 18-28 mechanistic target of rapamycin kinase Homo sapiens 165-194 30201609-2 2018 Recently, we have shown that mTOR complex 2 (mTORC2) modulates the hexosamine biosynthetic pathway (HBP) by promoting the expression of the key enzyme of the HBP, glutamine:fructose-6-phosphate aminotransferase 1 (GFAT1). Hexosamines 67-77 mechanistic target of rapamycin kinase Homo sapiens 29-33