PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17194895-1 2007 Heparin cofactor II (HCII) has several biochemical properties that distinguish it from other serpins: (1) it specifically inhibits thrombin; (2) the mechanism of inhibition involves binding of an acidic domain in HCII to thrombin exosite I; and (3) the rate of inhibition increases dramatically in the presence of dermatan sulfate molecules having specific structures. Dermatan Sulfate 314-330 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 0-19 20807652-3 2010 Endothelial injury allows circulating HCII to enter the vessel wall, where it binds to DS and presumably becomes activated. Dermatan Sulfate 87-89 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 38-42 20807652-7 2010 These observations suggest that a major function of the HCII-DS system is to regulate the physiologic response to arterial injury. Dermatan Sulfate 61-63 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 56-60 18281504-0 2008 Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor II. Dermatan Sulfate 9-25 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 67-86 18281504-2 2008 Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo. Dermatan Sulfate 0-16 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 94-98 18281504-2 2008 Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo. Dermatan Sulfate 0-16 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 207-211 18281504-2 2008 Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo. Dermatan Sulfate 18-20 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 94-98 18281504-4 2008 When HCII was incubated with frozen sections of the mouse carotid artery, it bound specifically to DS in the adventitia. Dermatan Sulfate 99-101 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 5-9 18281504-6 2008 These results support the hypothesis that HCII interacts with DS in the vessel wall after disruption of the endothelium and that this interaction regulates thrombus formation in vivo. Dermatan Sulfate 62-64 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 42-46 17878401-1 2007 Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin when bound to dermatan sulfate or heparin. Dermatan Sulfate 84-100 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 0-19 17878401-1 2007 Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin when bound to dermatan sulfate or heparin. Dermatan Sulfate 84-100 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 21-25 17194895-1 2007 Heparin cofactor II (HCII) has several biochemical properties that distinguish it from other serpins: (1) it specifically inhibits thrombin; (2) the mechanism of inhibition involves binding of an acidic domain in HCII to thrombin exosite I; and (3) the rate of inhibition increases dramatically in the presence of dermatan sulfate molecules having specific structures. Dermatan Sulfate 314-330 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 21-25 17194895-1 2007 Heparin cofactor II (HCII) has several biochemical properties that distinguish it from other serpins: (1) it specifically inhibits thrombin; (2) the mechanism of inhibition involves binding of an acidic domain in HCII to thrombin exosite I; and (3) the rate of inhibition increases dramatically in the presence of dermatan sulfate molecules having specific structures. Dermatan Sulfate 314-330 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 213-217 17194895-3 2007 Studies with HCII knockout mice directly support the hypothesis that HCII interacts with dermatan sulfate in the arterial wall after endothelial injury and thereby exerts an antithrombotic effect. Dermatan Sulfate 89-105 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 13-17 17194895-3 2007 Studies with HCII knockout mice directly support the hypothesis that HCII interacts with dermatan sulfate in the arterial wall after endothelial injury and thereby exerts an antithrombotic effect. Dermatan Sulfate 89-105 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 69-73 1805447-6 1991 On the other hand, A10 cells synthesized both dermatan sulfate and heparan sulfate which are capable of activating HCII. Dermatan Sulfate 46-62 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 115-119 15315969-1 2004 Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Dermatan Sulfate 97-113 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 0-19 15315969-1 2004 Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Dermatan Sulfate 97-113 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 21-25 15315969-4 2004 Intravenous administration of porcine skin dermatan sulfate induced a dose-dependent prolongation of the carotid artery occlusion time in HCII(+/+) mice that was not observed in HCII(-/-) animals. Dermatan Sulfate 43-59 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 138-142 15315969-4 2004 Intravenous administration of porcine skin dermatan sulfate induced a dose-dependent prolongation of the carotid artery occlusion time in HCII(+/+) mice that was not observed in HCII(-/-) animals. Dermatan Sulfate 43-59 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 178-182 15315969-6 2004 Using invertebrate dermatan sulfate preparations, we showed that N-acetylgalactosamine-4-O-sulfate residues are required for the HCII-dependent antithrombotic effect. Dermatan Sulfate 19-35 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 129-133 15315969-8 2004 These results indicate that HCII mediates the antithrombotic effect of porcine skin dermatan sulfate after injury to the carotid arterial endothelium in mice, whereas more highly charged dermatan sulfates possess weak antithrombotic activity independent of HCII. Dermatan Sulfate 84-100 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 28-32 11805133-1 2002 Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate, heparan sulfate, or heparin. Dermatan Sulfate 97-113 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 0-19 11805133-1 2002 Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate, heparan sulfate, or heparin. Dermatan Sulfate 97-113 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 21-25 1805447-7 1991 From these results, it was suggested that HCII would be activated by glycosaminoglycans (GAGs) such as dermatan sulfate of the cell layers and could inhibit thrombin-induced PGI2 production. Dermatan Sulfate 103-119 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 42-46 21250866-1 2011 BACKGROUND AIMS: Previously, we have demonstrated that administration of dermatan sulfate (DS) suppresses neointima formation in the mouse carotid artery by activating heparin co-factor II. Dermatan Sulfate 73-89 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 168-188 21676168-5 2011 RESULTS: Two dermatan sulfates isolated from the ascidians Styela plicata and Phallusia nigra, composed of the same disaccharide core structure (IdoA2-GalNAc)(n) , but sulfated at carbon 4 or 6 of the GalNAc, respectively, have opposed heparin cofactor II (HCII) activities and are potent inhibitors of P-selectin. Dermatan Sulfate 13-30 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 257-261 3258496-2 1988 Initial studies demonstrated that murine plasma contains a heparin cofactor II-like inhibitor as shown by the presence of a dermatan sulfate-sensitive thrombin inhibitor. Dermatan Sulfate 124-140 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 59-78 21250866-1 2011 BACKGROUND AIMS: Previously, we have demonstrated that administration of dermatan sulfate (DS) suppresses neointima formation in the mouse carotid artery by activating heparin co-factor II. Dermatan Sulfate 91-93 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 168-188