PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20652491-1 2010 Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is an X-linked inherited disorder caused by a deficiency of the enzyme iduronate-2-sulfatase (IDS), which results in the lysosomal accumulation of glycosaminoglycans (GAG) such as dermatan and heparan sulfate. Dermatan Sulfate 236-244 iduronate 2-sulfatase Homo sapiens 127-148 20652491-1 2010 Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is an X-linked inherited disorder caused by a deficiency of the enzyme iduronate-2-sulfatase (IDS), which results in the lysosomal accumulation of glycosaminoglycans (GAG) such as dermatan and heparan sulfate. Dermatan Sulfate 236-244 iduronate 2-sulfatase Homo sapiens 150-153 19602578-1 2009 Iduronate-2-sulfatase (IDS) is a lysosomal enzyme expressed in pancreatic islets responsible for the degradation of proteoglycans such as perlecan and dermatan sulfate. Dermatan Sulfate 151-167 iduronate 2-sulfatase Homo sapiens 0-21 19602578-1 2009 Iduronate-2-sulfatase (IDS) is a lysosomal enzyme expressed in pancreatic islets responsible for the degradation of proteoglycans such as perlecan and dermatan sulfate. Dermatan Sulfate 151-167 iduronate 2-sulfatase Homo sapiens 23-26 19707363-1 2008 Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is a heterogeneous, progressive X-linked recessively inherited lysosomal storage disease that is caused by a deficiency of the enzyme iduronate-2-sulfatase, resulting in abnormal tissue accumulation of the glycosaminoglycans, dermatan sulfate and heparan sulfate. Dermatan Sulfate 282-298 iduronate 2-sulfatase Homo sapiens 190-211 17616540-1 2007 Hunter syndrome (or Mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder due to the deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in the accumulation of heparan and dermatan sulfates in the lysosomes. Dermatan Sulfate 203-220 iduronate 2-sulfatase Homo sapiens 122-143 17616540-1 2007 Hunter syndrome (or Mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder due to the deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in the accumulation of heparan and dermatan sulfates in the lysosomes. Dermatan Sulfate 203-220 iduronate 2-sulfatase Homo sapiens 145-148 10447264-5 1999 The disease is caused by the inability to degrade dermatan sulphate and heparan sulphate due to mutations in the iduronate-2-sulphatase gene (IDS). Dermatan Sulfate 50-67 iduronate 2-sulfatase Homo sapiens 142-145 17876721-2 2007 I2S catalyses a step in the catabolism of glycosaminoglycans (GAGs) dermatan sulfate and heparan sulfate, and when it is deficient or absent GAGs accumulate in tissues and organs. Dermatan Sulfate 68-84 iduronate 2-sulfatase Homo sapiens 0-3 15500445-2 2005 IDS (iduronate-2-sulphatase; EC 3.1.6.13) is a lysosomal exo-sulphatase that belongs to this protein family and is involved in the degradation of the glycosaminoglycans heparan sulphate and dermatan sulphate. Dermatan Sulfate 190-207 iduronate 2-sulfatase Homo sapiens 0-3 15500445-2 2005 IDS (iduronate-2-sulphatase; EC 3.1.6.13) is a lysosomal exo-sulphatase that belongs to this protein family and is involved in the degradation of the glycosaminoglycans heparan sulphate and dermatan sulphate. Dermatan Sulfate 190-207 iduronate 2-sulfatase Homo sapiens 5-27 18174963-1 2007 Hunter syndrome (mucopolysaccharidosis II, MPS II) is a rare X-linked lysosomal storage disorder caused by the deficiency of enzyme iduronate-2-sulfatase (I2S), which results in accumulation of undegraded dermatan and heparan sulfate in various tissues and organs. Dermatan Sulfate 205-213 iduronate 2-sulfatase Homo sapiens 132-153 18174963-1 2007 Hunter syndrome (mucopolysaccharidosis II, MPS II) is a rare X-linked lysosomal storage disorder caused by the deficiency of enzyme iduronate-2-sulfatase (I2S), which results in accumulation of undegraded dermatan and heparan sulfate in various tissues and organs. Dermatan Sulfate 205-213 iduronate 2-sulfatase Homo sapiens 155-158 8530090-1 1995 Iduronate-2-sulfatase (IDS) is involved in the degradation of heparan sulfate and dermatan sulfate in the lysosomes, and a deficiency in this enzyme results in Hunter syndrome. Dermatan Sulfate 82-98 iduronate 2-sulfatase Homo sapiens 23-26 8530090-1 1995 Iduronate-2-sulfatase (IDS) is involved in the degradation of heparan sulfate and dermatan sulfate in the lysosomes, and a deficiency in this enzyme results in Hunter syndrome. Dermatan Sulfate 82-98 iduronate 2-sulfatase Homo sapiens 0-21 7626005-1 1995 Iduronate 2-sulphatase (IDS) is a lysosomal enzyme involved in degradation of dermatan sulphate and heparan sulphate. Dermatan Sulfate 78-95 iduronate 2-sulfatase Homo sapiens 0-22 7626005-1 1995 Iduronate 2-sulphatase (IDS) is a lysosomal enzyme involved in degradation of dermatan sulphate and heparan sulphate. Dermatan Sulfate 78-95 iduronate 2-sulfatase Homo sapiens 24-27 29884617-1 2018 The pediatric lysosomal storage disorder mucopolysaccharidosis type II is caused by mutations in IDS, resulting in accumulation of heparan and dermatan sulfate, causing severe neurodegeneration, skeletal disease, and cardiorespiratory disease. Dermatan Sulfate 143-159 iduronate 2-sulfatase Homo sapiens 97-100 8244397-1 1993 Deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS; EC 3.1.6.13) results in the storage of the glycosaminoglycans heparan sulfate and dermatan sulfate, which leads to the lysosomal storage disorder mucopolysaccharidosis type II. Dermatan Sulfate 145-161 iduronate 2-sulfatase Homo sapiens 35-56 8244397-1 1993 Deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS; EC 3.1.6.13) results in the storage of the glycosaminoglycans heparan sulfate and dermatan sulfate, which leads to the lysosomal storage disorder mucopolysaccharidosis type II. Dermatan Sulfate 145-161 iduronate 2-sulfatase Homo sapiens 58-61 34360653-2 2021 In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA). Dermatan Sulfate 69-85 iduronate 2-sulfatase Homo sapiens 142-163 34360653-2 2021 In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA). Dermatan Sulfate 69-85 iduronate 2-sulfatase Homo sapiens 165-168 34360653-2 2021 In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA). Dermatan Sulfate 87-89 iduronate 2-sulfatase Homo sapiens 142-163 34360653-2 2021 In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA). Dermatan Sulfate 87-89 iduronate 2-sulfatase Homo sapiens 165-168 7663435-1 1995 The iduronate-2-sulfatase (IDS) is a lysosomal enzyme that acts on sulphate groups on C-2 positions of the iduronic acid residues of the mucopolysaccharides heparan sulphate and dermatan sulphate. Dermatan Sulfate 178-195 iduronate 2-sulfatase Homo sapiens 4-25 2122463-1 1990 Iduronate 2-sulfatase (IDS, EC 3.1.6.13) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Dermatan Sulfate 106-122 iduronate 2-sulfatase Homo sapiens 0-21 2122463-1 1990 Iduronate 2-sulfatase (IDS, EC 3.1.6.13) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Dermatan Sulfate 106-122 iduronate 2-sulfatase Homo sapiens 23-26 28401457-1 2017 IDS is responsible for the lysosomal degradation of heparan sulfate and dermatan sulfate and linked to an X-linked lysosomal storage disease, mucopolysaccharidosis 2 (MPS2), resulting in neurological damage and early death. Dermatan Sulfate 72-88 iduronate 2-sulfatase Homo sapiens 0-3 28593992-1 2017 Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate. Dermatan Sulfate 185-201 iduronate 2-sulfatase Homo sapiens 87-90 28593992-1 2017 Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate. Dermatan Sulfate 185-201 iduronate 2-sulfatase Homo sapiens 105-126 29671225-2 2018 Deficiency of the lysosomal enzyme, iduronate-2-sulfatase (EC 3.1.6.13) results in deposition of the glycosaminoglycans, dermatan, and heparan sulfate in various tissues. Dermatan Sulfate 121-129 iduronate 2-sulfatase Homo sapiens 36-57 28588666-1 2017 Hunter syndrome (or mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder induced by a deficiency of the iduronate 2-sulfatase (IDS) enzyme, resulting in the accumulation of glycosaminoglycan substrates, heparan sulfate and dermatan sulfate, in the lysosomes. Dermatan Sulfate 243-259 iduronate 2-sulfatase Homo sapiens 124-145 28588666-1 2017 Hunter syndrome (or mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder induced by a deficiency of the iduronate 2-sulfatase (IDS) enzyme, resulting in the accumulation of glycosaminoglycan substrates, heparan sulfate and dermatan sulfate, in the lysosomes. Dermatan Sulfate 243-259 iduronate 2-sulfatase Homo sapiens 147-150 23512580-0 2013 Plasmatic kinetics of dermatan sulfate during enzyme replacement therapy with iduronate-2-sulfatase in a mucopolysaccharidosis II patient. Dermatan Sulfate 22-38 iduronate 2-sulfatase Homo sapiens 78-99 25622168-2 2015 Mucopolysaccharidosis type II (MPS II) is an X-linked recessive disorder characterized by a deficiency of the enzyme iduronate-2-sulfatase leading to a multisystem involvement by tissue accumulation of glycosaminoglycans heparan and dermatan sulfate. Dermatan Sulfate 233-249 iduronate 2-sulfatase Homo sapiens 117-138 23512580-2 2013 We report a kinetic study of plasmatic dermatan sulfate (DS) in a 3-year-old subject affected by a severe form of MPS II during the first 10 months of ERT with Idursulfase. Dermatan Sulfate 39-55 iduronate 2-sulfatase Homo sapiens 160-171 23512580-2 2013 We report a kinetic study of plasmatic dermatan sulfate (DS) in a 3-year-old subject affected by a severe form of MPS II during the first 10 months of ERT with Idursulfase. Dermatan Sulfate 57-59 iduronate 2-sulfatase Homo sapiens 160-171 23707223-1 2013 Hunter disease or mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal disorder caused by the deficit of the enzyme iduronate-2-sulfatase (IDS), involved in the catabolism of the glycosaminoglycans heparan and dermatan sulfate. Dermatan Sulfate 231-247 iduronate 2-sulfatase Homo sapiens 137-158 23707223-1 2013 Hunter disease or mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal disorder caused by the deficit of the enzyme iduronate-2-sulfatase (IDS), involved in the catabolism of the glycosaminoglycans heparan and dermatan sulfate. Dermatan Sulfate 231-247 iduronate 2-sulfatase Homo sapiens 160-163 23801937-1 2013 Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a rare, X-linked disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase, which catalyses a step in the catabolism of glycosaminoglycans resulting in accumulation of heparan and dermatan sulfate in many organs and tissues. Dermatan Sulfate 273-289 iduronate 2-sulfatase Homo sapiens 146-167 21193389-8 2011 Examination of chondroitin/dermatan sulfate catabolic enzymes showed that heparan sulfate and heparin can inhibit iduronate 2-sulfatase. Dermatan Sulfate 27-43 iduronate 2-sulfatase Homo sapiens 114-135 21193389-9 2011 Analysis of the chondroitin/dermatan sulfate fraction by chondroitinase ACII digestion showed dermatan sulfate storage, consistent with inhibition of iduronate 2-sulfatase. Dermatan Sulfate 28-44 iduronate 2-sulfatase Homo sapiens 150-171