PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21805439-10 2011 Additionally, pharmaceuticals are being developed that use the dermatan sulfate activation of HCII for anticoagulation. Dermatan Sulfate 63-79 serpin family D member 1 Homo sapiens 94-98 22987196-1 2013 Dermatan sulfate (DS) is well-known for its anticoagulant activity through binding to heparin cofactor II (HCII) to enhance thrombin inhibition. Dermatan Sulfate 0-16 serpin family D member 1 Homo sapiens 86-105 22987196-1 2013 Dermatan sulfate (DS) is well-known for its anticoagulant activity through binding to heparin cofactor II (HCII) to enhance thrombin inhibition. Dermatan Sulfate 0-16 serpin family D member 1 Homo sapiens 107-111 22987196-1 2013 Dermatan sulfate (DS) is well-known for its anticoagulant activity through binding to heparin cofactor II (HCII) to enhance thrombin inhibition. Dermatan Sulfate 18-20 serpin family D member 1 Homo sapiens 86-105 22987196-1 2013 Dermatan sulfate (DS) is well-known for its anticoagulant activity through binding to heparin cofactor II (HCII) to enhance thrombin inhibition. Dermatan Sulfate 18-20 serpin family D member 1 Homo sapiens 107-111 16339402-0 2006 Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II. Dermatan Sulfate 10-26 serpin family D member 1 Homo sapiens 84-103 16650906-1 2007 BACKGROUND: Heparin cofactor II (HCII) could inactivate thrombin after binding to dermatan sulfate at injured arterial walls, and has been shown to be a novel and independent antiatherosclerotic factor. Dermatan Sulfate 82-98 serpin family D member 1 Homo sapiens 12-31 16650906-1 2007 BACKGROUND: Heparin cofactor II (HCII) could inactivate thrombin after binding to dermatan sulfate at injured arterial walls, and has been shown to be a novel and independent antiatherosclerotic factor. Dermatan Sulfate 82-98 serpin family D member 1 Homo sapiens 33-37 16624894-0 2006 N-Acetylgalactosamine 4,6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfate. Dermatan Sulfate 118-134 serpin family D member 1 Homo sapiens 79-98 16624894-1 2006 Dermatan sulfate (DS) accelerates the inhibition of thrombin by heparin cofactor II (HCII). Dermatan Sulfate 0-16 serpin family D member 1 Homo sapiens 64-83 16624894-1 2006 Dermatan sulfate (DS) accelerates the inhibition of thrombin by heparin cofactor II (HCII). Dermatan Sulfate 0-16 serpin family D member 1 Homo sapiens 85-89 16624894-1 2006 Dermatan sulfate (DS) accelerates the inhibition of thrombin by heparin cofactor II (HCII). Dermatan Sulfate 18-20 serpin family D member 1 Homo sapiens 64-83 16624894-1 2006 Dermatan sulfate (DS) accelerates the inhibition of thrombin by heparin cofactor II (HCII). Dermatan Sulfate 18-20 serpin family D member 1 Homo sapiens 85-89 16624894-3 2006 DS from porcine intestinal mucosa has a much lower content of this disaccharide but activates HCII with potency similar to that of porcine skin DS. Dermatan Sulfate 0-2 serpin family D member 1 Homo sapiens 94-98 16624894-4 2006 Therefore, we sought to characterize oligosaccharides from porcine mucosal DS that interact with HCII. Dermatan Sulfate 75-77 serpin family D member 1 Homo sapiens 97-101 16624894-11 2006 These data support the hypothesis that modification of IdoA-->GalNAc4SO3 subunits in the DS polymer by either 2-O-sulfation of IdoA or 6-O-sulfation of GalNAc can generate molecules with HCII-binding sites and anticoagulant activity. Dermatan Sulfate 92-94 serpin family D member 1 Homo sapiens 190-194 20670608-1 2010 Irreversible inactivation of alpha-thrombin (T) by the serpin, heparin cofactor II (HCII), is accelerated by ternary complex formation with the glycosaminoglycans (GAGs) heparin and dermatan sulfate (DS). Dermatan Sulfate 182-198 serpin family D member 1 Homo sapiens 63-82 20670608-1 2010 Irreversible inactivation of alpha-thrombin (T) by the serpin, heparin cofactor II (HCII), is accelerated by ternary complex formation with the glycosaminoglycans (GAGs) heparin and dermatan sulfate (DS). Dermatan Sulfate 182-198 serpin family D member 1 Homo sapiens 84-88 20670608-1 2010 Irreversible inactivation of alpha-thrombin (T) by the serpin, heparin cofactor II (HCII), is accelerated by ternary complex formation with the glycosaminoglycans (GAGs) heparin and dermatan sulfate (DS). Dermatan Sulfate 200-202 serpin family D member 1 Homo sapiens 63-82 20670608-1 2010 Irreversible inactivation of alpha-thrombin (T) by the serpin, heparin cofactor II (HCII), is accelerated by ternary complex formation with the glycosaminoglycans (GAGs) heparin and dermatan sulfate (DS). Dermatan Sulfate 200-202 serpin family D member 1 Homo sapiens 84-88 18971786-2 2008 BACKGROUND: HCII inhibits thrombin activity by binding to dermatan sulfate and has been shown to be a novel and independent risk factor for atherosclerosis. Dermatan Sulfate 58-74 serpin family D member 1 Homo sapiens 12-16 17222891-6 2007 In the presence of HCII, DSb, a slightly oversulfated DS, had the highest inhibitory effect, whereas heparin and DSd, the most oversulfated derivative, had lower potencies in this case. Dermatan Sulfate 25-27 serpin family D member 1 Homo sapiens 19-23 17222891-7 2007 These data suggest that the inhibition of thrombin-induced platelet aggregation by the oversulfated DS derivatives is related to their ability to potentiate thrombin inactivation by AT or HCII. Dermatan Sulfate 100-102 serpin family D member 1 Homo sapiens 188-192 16339402-4 2006 Dermatan sulfate (DS) specifically activates HCII and is abundant in the placenta, but the locations of DS and HCII in the placenta have not been determined. Dermatan Sulfate 0-16 serpin family D member 1 Homo sapiens 45-49 16339402-4 2006 Dermatan sulfate (DS) specifically activates HCII and is abundant in the placenta, but the locations of DS and HCII in the placenta have not been determined. Dermatan Sulfate 18-20 serpin family D member 1 Homo sapiens 45-49 16339402-6 2006 DS isolated from human placenta contains disaccharides implicated in activation of HCII and has anticoagulant activity similar to that of mucosal DS. Dermatan Sulfate 0-2 serpin family D member 1 Homo sapiens 83-87 16339402-8 2006 HCII colocalizes with DS in the walls of fetal blood vessels and is also present in syncytiotrophoblast cells. Dermatan Sulfate 22-24 serpin family D member 1 Homo sapiens 0-4 16339402-9 2006 Our data suggest that DS is in a position to activate HCII in the fetal blood vessels or in the stroma of placental villi after injury to the syncytiotrophoblast layer and thereby inhibit fibrin generation in the placenta. Dermatan Sulfate 22-24 serpin family D member 1 Homo sapiens 54-58 15315969-7 2004 Furthermore, the invertebrate dermatan sulfates, which have higher charge densities than mammalian dermatan sulfate, slightly prolonged the thrombotic occlusion time of HCII(-/-) mice. Dermatan Sulfate 30-47 serpin family D member 1 Homo sapiens 169-173 15315969-7 2004 Furthermore, the invertebrate dermatan sulfates, which have higher charge densities than mammalian dermatan sulfate, slightly prolonged the thrombotic occlusion time of HCII(-/-) mice. Dermatan Sulfate 30-46 serpin family D member 1 Homo sapiens 169-173 14744972-2 2004 Because heparin cofactor II (HCII) inhibits thrombin action in the presence of dermatan sulfate, which is abundantly present in arterial wall, HCII may affect vascular remodeling by modulating thrombin action. Dermatan Sulfate 79-95 serpin family D member 1 Homo sapiens 8-27 15148272-2 2004 Because heparin cofactor II (HCII) inhibits thrombin actions after binding to dermatan sulfate at injured arterial walls, HCII may negatively regulate thrombin actions in vascular walls. Dermatan Sulfate 78-94 serpin family D member 1 Homo sapiens 8-27 15148272-2 2004 Because heparin cofactor II (HCII) inhibits thrombin actions after binding to dermatan sulfate at injured arterial walls, HCII may negatively regulate thrombin actions in vascular walls. Dermatan Sulfate 78-94 serpin family D member 1 Homo sapiens 29-33 15148272-2 2004 Because heparin cofactor II (HCII) inhibits thrombin actions after binding to dermatan sulfate at injured arterial walls, HCII may negatively regulate thrombin actions in vascular walls. Dermatan Sulfate 78-94 serpin family D member 1 Homo sapiens 122-126 14744972-2 2004 Because heparin cofactor II (HCII) inhibits thrombin action in the presence of dermatan sulfate, which is abundantly present in arterial wall, HCII may affect vascular remodeling by modulating thrombin action. Dermatan Sulfate 79-95 serpin family D member 1 Homo sapiens 29-33 14744972-2 2004 Because heparin cofactor II (HCII) inhibits thrombin action in the presence of dermatan sulfate, which is abundantly present in arterial wall, HCII may affect vascular remodeling by modulating thrombin action. Dermatan Sulfate 79-95 serpin family D member 1 Homo sapiens 143-147 12149217-8 2002 A drastic decrease (up to 500-fold) of the second-order rate constant pertaining to heparin cofactor II (HCII) interaction, especially in the presence of dermatan sulfate, was found for the FIIa-MT67 compared with FIIa-WT, suggesting a severe impairment of thrombin inhibition by HCII in vivo. Dermatan Sulfate 154-170 serpin family D member 1 Homo sapiens 84-103 12818259-10 2003 CONCLUSIONS: Thrombin inhibition produced by sulodexide is due to the additive effect of its components, namely, HCII catalysis by DS and AT catalysis by FMH. Dermatan Sulfate 131-133 serpin family D member 1 Homo sapiens 113-117 15078125-1 2004 Heparin and other iduronic acid-containing glycosaminoglycans (GAG) such as dermatan sulfate exert their anticoagulant properties primarily by accelerating the rate of inhibition of the natural protease inhibitors antithrombin III (AT, which inhibits both factor Xa and thrombin) and heparin cofactor II (HCII, which selectively inhibits thrombin). Dermatan Sulfate 76-92 serpin family D member 1 Homo sapiens 284-303 15078125-1 2004 Heparin and other iduronic acid-containing glycosaminoglycans (GAG) such as dermatan sulfate exert their anticoagulant properties primarily by accelerating the rate of inhibition of the natural protease inhibitors antithrombin III (AT, which inhibits both factor Xa and thrombin) and heparin cofactor II (HCII, which selectively inhibits thrombin). Dermatan Sulfate 76-92 serpin family D member 1 Homo sapiens 305-309 15078125-2 2004 Although AT and HCII are structural homologs, only heparin binds to AT, and HCII has different binding sites for heparin and dermatan sulfate. Dermatan Sulfate 125-141 serpin family D member 1 Homo sapiens 76-80 15078125-3 2004 Whereas the binding site of heparin for AT is a unique pentasaccharide sequence contained in only about one third of the chains of this GAG, HCII-binding sequences of heparin and dermatan sulfate are less specific and contained in practically all the GAG chains. Dermatan Sulfate 179-195 serpin family D member 1 Homo sapiens 141-145 15078125-6 2004 Whereas it inactivates the binding site for AT causing a drop of the anticoagulant activity, it enhances the HCII-associated activity of both heparin and dermatan sulfate. Dermatan Sulfate 154-170 serpin family D member 1 Homo sapiens 109-113 12149217-8 2002 A drastic decrease (up to 500-fold) of the second-order rate constant pertaining to heparin cofactor II (HCII) interaction, especially in the presence of dermatan sulfate, was found for the FIIa-MT67 compared with FIIa-WT, suggesting a severe impairment of thrombin inhibition by HCII in vivo. Dermatan Sulfate 154-170 serpin family D member 1 Homo sapiens 105-109 12413592-6 2002 Dermatan sulfate (DSO4)-catalyzed HCII thrombin inhibition was unchanged in R93A/R97A/R101A thrombin compared to wild-type recombinant thrombin. Dermatan Sulfate 0-16 serpin family D member 1 Homo sapiens 34-38 12095635-0 2002 Contribution of basic residues of the A helix of heparin cofactor II to heparin- or dermatan sulfate-mediated thrombin inhibition. Dermatan Sulfate 84-100 serpin family D member 1 Homo sapiens 49-68 12095635-1 2002 Inhibition of thrombin by heparin cofactor II (HCII) is accelerated 1000-fold by heparin or dermatan sulfate. Dermatan Sulfate 92-108 serpin family D member 1 Homo sapiens 26-45 12095635-1 2002 Inhibition of thrombin by heparin cofactor II (HCII) is accelerated 1000-fold by heparin or dermatan sulfate. Dermatan Sulfate 92-108 serpin family D member 1 Homo sapiens 47-51 12095635-5 2002 These results provide evidence that basic residues of the A helix of HCII (Lys(101) and Arg(106)) are necessary for heparin- or dermatan sulfate-accelerated thrombin inhibition. Dermatan Sulfate 128-144 serpin family D member 1 Homo sapiens 69-73 10749870-2 2000 The dermatan sulfate chains are known to stimulate thrombin inhibition by heparin cofactor II (HCII), a plasma proteinase inhibitor that has been detected within the artery wall. Dermatan Sulfate 4-20 serpin family D member 1 Homo sapiens 74-93 10749870-2 2000 The dermatan sulfate chains are known to stimulate thrombin inhibition by heparin cofactor II (HCII), a plasma proteinase inhibitor that has been detected within the artery wall. Dermatan Sulfate 4-20 serpin family D member 1 Homo sapiens 95-99 10753952-1 2000 Heparin cofactor II (HCII) is a plasma serine protease inhibitor whose ability to inhibit alpha-thrombin is accelerated by a variety of sulfated polysaccharides in addition to heparin and dermatan sulfate. Dermatan Sulfate 188-204 serpin family D member 1 Homo sapiens 0-19 10753952-1 2000 Heparin cofactor II (HCII) is a plasma serine protease inhibitor whose ability to inhibit alpha-thrombin is accelerated by a variety of sulfated polysaccharides in addition to heparin and dermatan sulfate. Dermatan Sulfate 188-204 serpin family D member 1 Homo sapiens 21-25 10494755-1 1999 Heparin cofactor II (HCII) is a specific inhibitor of thrombin in the presence of heparin or dermatan sulphate. Dermatan Sulfate 93-110 serpin family D member 1 Homo sapiens 0-19 10488098-0 1999 Comparison of heparin- and dermatan sulfate-mediated catalysis of thrombin inactivation by heparin cofactor II. Dermatan Sulfate 27-43 serpin family D member 1 Homo sapiens 91-110 10488098-1 1999 Heparin and dermatan sulfate activate heparin cofactor II (HCII) comparably, presumably by liberating the amino terminus of HCII to bind to exosite I of thrombin. Dermatan Sulfate 12-28 serpin family D member 1 Homo sapiens 38-57 10488098-1 1999 Heparin and dermatan sulfate activate heparin cofactor II (HCII) comparably, presumably by liberating the amino terminus of HCII to bind to exosite I of thrombin. Dermatan Sulfate 12-28 serpin family D member 1 Homo sapiens 59-63 10488098-1 1999 Heparin and dermatan sulfate activate heparin cofactor II (HCII) comparably, presumably by liberating the amino terminus of HCII to bind to exosite I of thrombin. Dermatan Sulfate 12-28 serpin family D member 1 Homo sapiens 124-128 10488098-7 1999 Fluorescence spectroscopy revealed that dermatan sulfate evokes greater conformational changes in HCII than heparin, suggesting that dermatan sulfate stimulates HCII by producing more effective displacement of the amino terminus. Dermatan Sulfate 40-56 serpin family D member 1 Homo sapiens 98-102 10488098-7 1999 Fluorescence spectroscopy revealed that dermatan sulfate evokes greater conformational changes in HCII than heparin, suggesting that dermatan sulfate stimulates HCII by producing more effective displacement of the amino terminus. Dermatan Sulfate 133-149 serpin family D member 1 Homo sapiens 98-102 10488098-7 1999 Fluorescence spectroscopy revealed that dermatan sulfate evokes greater conformational changes in HCII than heparin, suggesting that dermatan sulfate stimulates HCII by producing more effective displacement of the amino terminus. Dermatan Sulfate 133-149 serpin family D member 1 Homo sapiens 161-165 10494755-1 1999 Heparin cofactor II (HCII) is a specific inhibitor of thrombin in the presence of heparin or dermatan sulphate. Dermatan Sulfate 93-110 serpin family D member 1 Homo sapiens 21-25 10209287-8 1999 These results suggest that, like dermatan sulphate and heparin, other polyanions stimulate HCII primarily by an allosteric mechanism requiring the N-terminal acidic domain. Dermatan Sulfate 33-50 serpin family D member 1 Homo sapiens 91-95 10209287-1 1999 A variety of sulphated polyanions in addition to heparin and dermatan sulphate stimulate the inhibition of thrombin by heparin cofactor II (HCII). Dermatan Sulfate 61-78 serpin family D member 1 Homo sapiens 119-138 10209287-1 1999 A variety of sulphated polyanions in addition to heparin and dermatan sulphate stimulate the inhibition of thrombin by heparin cofactor II (HCII). Dermatan Sulfate 61-78 serpin family D member 1 Homo sapiens 140-144 10209287-2 1999 Previous investigations indicated that the binding sites on HCII for heparin and dermatan sulphate overlap but are not identical. Dermatan Sulfate 81-98 serpin family D member 1 Homo sapiens 60-64 10093889-5 1999 For example, we suggest that the heparin cofactor II (HCII) catalysts, dermatan sulfate and Intimatan, inhibit surface-bound thrombin more effectively than heparin/ATIII, thereby inhibiting intimal hyperplasia effectively. Dermatan Sulfate 71-87 serpin family D member 1 Homo sapiens 33-52 10093889-5 1999 For example, we suggest that the heparin cofactor II (HCII) catalysts, dermatan sulfate and Intimatan, inhibit surface-bound thrombin more effectively than heparin/ATIII, thereby inhibiting intimal hyperplasia effectively. Dermatan Sulfate 71-87 serpin family D member 1 Homo sapiens 54-58 9813026-10 1998 The larger effects of the thrombin exosite-I mutants for HCII inhibition with heparin and dermatan sulfate indicate its need for exosite-I, presumably through contact of the "hirudin-like" domain of HCII with exosite-I of thrombin. Dermatan Sulfate 90-106 serpin family D member 1 Homo sapiens 199-203 10349131-1 1999 Heparin Cofactor II (HCII) is a glycoprotein in human plasma which inactivates thrombin rapidly in the presence of dermatan sulfate. Dermatan Sulfate 115-131 serpin family D member 1 Homo sapiens 0-19 10349131-1 1999 Heparin Cofactor II (HCII) is a glycoprotein in human plasma which inactivates thrombin rapidly in the presence of dermatan sulfate. Dermatan Sulfate 115-131 serpin family D member 1 Homo sapiens 21-25 10349131-7 1999 HCII thrombin inhibition possibly takes place in extravascular sites where dermatan sulfate is present. Dermatan Sulfate 75-91 serpin family D member 1 Homo sapiens 0-4 9485475-1 1998 Heparin cofactor II (HCII) inhibits thrombin rapidly in the presence of heparin or dermatan sulfate. Dermatan Sulfate 83-99 serpin family D member 1 Homo sapiens 0-19 9843172-1 1998 Heparin cofactor II (HCII) is a serpin that inhibits thrombin rapidly in the presence of heparin or dermatan sulfate. Dermatan Sulfate 100-116 serpin family D member 1 Homo sapiens 0-19 9843172-1 1998 Heparin cofactor II (HCII) is a serpin that inhibits thrombin rapidly in the presence of heparin or dermatan sulfate. Dermatan Sulfate 100-116 serpin family D member 1 Homo sapiens 21-25 9485475-1 1998 Heparin cofactor II (HCII) inhibits thrombin rapidly in the presence of heparin or dermatan sulfate. Dermatan Sulfate 83-99 serpin family D member 1 Homo sapiens 21-25 9353333-5 1997 Purified recombinant meizothrombin and meizothrombin(desF1) were inhibited by HCII in the presence of dermatan sulfate with maximal second-order rate constants of 8 x 10(6) M-1.min-1 and 1.8 x 10(7) M-1.min-1, respectively, but were inhibited less than one-tenth as fast by AT in the presence of heparin. Dermatan Sulfate 102-118 serpin family D member 1 Homo sapiens 78-82 9353333-7 1997 When HCII and dermatan sulfate were present continuously during the prothrombinase reaction, meizothrombin was trapped as a sodium dodecyl sulfate-stable complex with HCII and no amidolytic activity could be detected with a thrombin substrate. Dermatan Sulfate 14-30 serpin family D member 1 Homo sapiens 167-171 8017769-4 1994 Finally, in the presence of dermatan sulfate or heparin, the N-terminal acidic region of HCII may interact with the hirudin-binding site of thrombin to produce maximal stimulation of the thrombin-HCII reaction. Dermatan Sulfate 28-44 serpin family D member 1 Homo sapiens 89-93 9068899-0 1997 Mechanism of thrombin inhibition by heparin cofactor II in the presence of dermatan sulphates, native or oversulphated, and a heparin-like dextran derivative. Dermatan Sulfate 75-93 serpin family D member 1 Homo sapiens 36-55 8792767-1 1996 Heparin cofactor II (HCII) is a potent thrombin inhibitor in the presence of heparin and dermatan sulfate, glycosaminoglycans that accelerate the inhibition reaction. Dermatan Sulfate 89-105 serpin family D member 1 Homo sapiens 0-19 8792767-1 1996 Heparin cofactor II (HCII) is a potent thrombin inhibitor in the presence of heparin and dermatan sulfate, glycosaminoglycans that accelerate the inhibition reaction. Dermatan Sulfate 89-105 serpin family D member 1 Homo sapiens 21-25 8017769-1 1994 The binding sites for dermatan sulfate and heparin in HCII overlap but are not identical. Dermatan Sulfate 22-38 serpin family D member 1 Homo sapiens 54-58 8017769-2 1994 This may explain the observation that HCII binds nonspecifically to heparin oligosaccharides, but preferentially binds to a minor hexasaccharide isolated from dermatan sulfate. Dermatan Sulfate 159-175 serpin family D member 1 Homo sapiens 38-42 8017769-3 1994 The tissue distribution of dermatan sulfate molecules containing the high-affinity HCII binding site may regulate HCII activity in vivo. Dermatan Sulfate 27-43 serpin family D member 1 Homo sapiens 83-87 8017769-3 1994 The tissue distribution of dermatan sulfate molecules containing the high-affinity HCII binding site may regulate HCII activity in vivo. Dermatan Sulfate 27-43 serpin family D member 1 Homo sapiens 114-118 8885144-0 1996 Active site for heparin cofactor II in low molecular mass dermatan sulfate. Dermatan Sulfate 58-74 serpin family D member 1 Homo sapiens 16-35 8885144-3 1996 Unlike heparin, DS does not act through Antithrombin III (ATIII) but primarily through thrombin on Heparin Cofactor II (HCII). Dermatan Sulfate 16-18 serpin family D member 1 Homo sapiens 99-118 8885144-3 1996 Unlike heparin, DS does not act through Antithrombin III (ATIII) but primarily through thrombin on Heparin Cofactor II (HCII). Dermatan Sulfate 16-18 serpin family D member 1 Homo sapiens 120-124 8885144-10 1996 The important influence on the HCII activity of natural IdoA-GalNAc-4,6SO3 disaccharide was confirmed by investigation on oversulfated DS obtained by a limited and selective chemical 6-O-sulfation in GalNAc4SO3 units of DS. Dermatan Sulfate 135-137 serpin family D member 1 Homo sapiens 31-35 8885144-10 1996 The important influence on the HCII activity of natural IdoA-GalNAc-4,6SO3 disaccharide was confirmed by investigation on oversulfated DS obtained by a limited and selective chemical 6-O-sulfation in GalNAc4SO3 units of DS. Dermatan Sulfate 220-222 serpin family D member 1 Homo sapiens 31-35 8562924-1 1996 Heparin cofactor II (HCII) is a serine proteinase inhibitor in human plasma that rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. Dermatan Sulfate 126-142 serpin family D member 1 Homo sapiens 0-19 8562924-1 1996 Heparin cofactor II (HCII) is a serine proteinase inhibitor in human plasma that rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. Dermatan Sulfate 126-142 serpin family D member 1 Homo sapiens 21-25 8815580-3 1996 In conditioned medium, HuH-7 cells constantly produced HC II that was functionally active and formed a complex with thrombin in the presence of dermatan sulfate. Dermatan Sulfate 144-160 serpin family D member 1 Homo sapiens 55-60 8091403-0 1994 Relative influence of different disulphate disaccharide clusters on the HCII-mediated inhibition of thrombin by dermatan sulphates of different origins. Dermatan Sulfate 112-130 serpin family D member 1 Homo sapiens 72-76 8091403-1 1994 Besides the major monosulphated disaccharide sequences (IdoA-GalNAc4SO3), dermatan sulphates (DS) contain the oversulphated sequences (IdoA2SO3-GalNAc4SO3) and (IdoA-GalNAc4, 6SO3), the concentration of which is correlated with the HCII-mediated inhibition of thrombin by DS. Dermatan Sulfate 74-92 serpin family D member 1 Homo sapiens 232-236 8017769-4 1994 Finally, in the presence of dermatan sulfate or heparin, the N-terminal acidic region of HCII may interact with the hirudin-binding site of thrombin to produce maximal stimulation of the thrombin-HCII reaction. Dermatan Sulfate 28-44 serpin family D member 1 Homo sapiens 196-200 8181003-7 1994 The HCII activities were evaluated for different relative molecular mass of dermatan sulfate. Dermatan Sulfate 76-92 serpin family D member 1 Homo sapiens 4-8 7908224-1 1994 Heparin cofactor II (HCII) is a glycoprotein in human plasma that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Dermatan Sulfate 111-127 serpin family D member 1 Homo sapiens 0-19 7908224-1 1994 Heparin cofactor II (HCII) is a glycoprotein in human plasma that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Dermatan Sulfate 111-127 serpin family D member 1 Homo sapiens 21-25 8335699-1 1993 Three sulphated polysaccharides, dermatan sulphate, fucan and heparin, were fractionated according to their affinity towards antithrombin III (ATIII) and heparin cofactor II (HCII), the two main physiological thrombin (IIa) inhibitors. Dermatan Sulfate 33-50 serpin family D member 1 Homo sapiens 154-173 8259546-6 1993 DS addition selectively increases the formation of heparin cofactor II (HCII)-IIa complexes, whereas LMWH enhances ATIII-IIa complex generation. Dermatan Sulfate 0-2 serpin family D member 1 Homo sapiens 72-76 8335699-1 1993 Three sulphated polysaccharides, dermatan sulphate, fucan and heparin, were fractionated according to their affinity towards antithrombin III (ATIII) and heparin cofactor II (HCII), the two main physiological thrombin (IIa) inhibitors. Dermatan Sulfate 33-50 serpin family D member 1 Homo sapiens 175-179 1579900-0 1992 Use of purified dermatan sulfate for heparin cofactor II (HC II) assay. Dermatan Sulfate 16-32 serpin family D member 1 Homo sapiens 37-56 1521342-2 1992 Heparin cofactor II (HCII) is a thrombin inhibitor in human plasma, the activity of which is enhanced by heparin and dermatan sulfate. Dermatan Sulfate 117-133 serpin family D member 1 Homo sapiens 0-19 1521342-2 1992 Heparin cofactor II (HCII) is a thrombin inhibitor in human plasma, the activity of which is enhanced by heparin and dermatan sulfate. Dermatan Sulfate 117-133 serpin family D member 1 Homo sapiens 21-25 8429040-9 1993 The rate constants for inhibition of wild-type thrombin by HCII in the presence of heparin or dermatan sulfate were 9.2 x 10(8) M-1 min-1 and 9.0 x 10(8) M-1 min-1, respectively. Dermatan Sulfate 94-110 serpin family D member 1 Homo sapiens 59-63 1333106-3 1992 In the present study the inhibitory activity of HC II was investigated as function of various dermatan sulfate fractions and its stability was tested against oxidation reagents similar to thus secreted by activated leucocytes. Dermatan Sulfate 94-110 serpin family D member 1 Homo sapiens 48-53 1333106-4 1992 High affinity dermatan sulfate (DS) increased the antithrombin inhibition activity of HC II about 1000-fold in contrast to about 100-fold in the case of low affinity DS. Dermatan Sulfate 14-30 serpin family D member 1 Homo sapiens 86-91 1333106-4 1992 High affinity dermatan sulfate (DS) increased the antithrombin inhibition activity of HC II about 1000-fold in contrast to about 100-fold in the case of low affinity DS. Dermatan Sulfate 32-34 serpin family D member 1 Homo sapiens 86-91 1381850-1 1992 Heparin cofactor II (HCII) is a specific thrombin inhibitor; its inhibitory activity is stimulated by heparin (Hep) and dermatan sulfate (DS). Dermatan Sulfate 120-136 serpin family D member 1 Homo sapiens 21-25 1381850-1 1992 Heparin cofactor II (HCII) is a specific thrombin inhibitor; its inhibitory activity is stimulated by heparin (Hep) and dermatan sulfate (DS). Dermatan Sulfate 138-140 serpin family D member 1 Homo sapiens 21-25 1442260-1 1992 The binding sites for dermatan sulfate and heparin in HCII overlap but are not identical. Dermatan Sulfate 22-38 serpin family D member 1 Homo sapiens 54-58 1442260-2 1992 This may explain the observation that HCII binds non-specifically to heparin oligosaccharides but preferentially binds to a minor hexasaccharide isolated from dermatan sulfate having the structure shown in Fig. Dermatan Sulfate 159-175 serpin family D member 1 Homo sapiens 38-42 1442260-4 1992 The tissue distribution of dermatan sulfate molecules containing the high-affinity HCII binding site may regulate HCII activity in vivo. Dermatan Sulfate 27-43 serpin family D member 1 Homo sapiens 83-87 1442260-4 1992 The tissue distribution of dermatan sulfate molecules containing the high-affinity HCII binding site may regulate HCII activity in vivo. Dermatan Sulfate 27-43 serpin family D member 1 Homo sapiens 114-118 1442260-5 1992 Finally, in the presence of dermatan sulfate or heparin, the N-terminal acidic domain of HCII may interact with the hirudin-binding site of thrombin to produce maximal stimulation of the thrombin-HCII reaction. Dermatan Sulfate 28-44 serpin family D member 1 Homo sapiens 89-93 1442260-5 1992 Finally, in the presence of dermatan sulfate or heparin, the N-terminal acidic domain of HCII may interact with the hirudin-binding site of thrombin to produce maximal stimulation of the thrombin-HCII reaction. Dermatan Sulfate 28-44 serpin family D member 1 Homo sapiens 196-200 1554154-5 1992 In fact, HRG is 10 times less effective than PF 4 in neutralizing the 50% antithrombin activity of HC II in the presence of DS. Dermatan Sulfate 124-126 serpin family D member 1 Homo sapiens 99-104 1579900-0 1992 Use of purified dermatan sulfate for heparin cofactor II (HC II) assay. Dermatan Sulfate 16-32 serpin family D member 1 Homo sapiens 58-63 1646210-0 1991 Immobilization of dermatan sulphate on a silica matrix and its possible use as an affinity chromatography support for heparin cofactor II purification. Dermatan Sulfate 18-35 serpin family D member 1 Homo sapiens 118-137 1831893-8 1991 The relationship between these severe venous thrombotic episodes and the HCII deficiency is discussed in relation to the dermatan sulphate-HCII couple physiology. Dermatan Sulfate 121-138 serpin family D member 1 Homo sapiens 73-77 1646210-5 1991 The DS bound to the silica matrix was also tested as a chromatographic support for the purification of HCII from human plasma; the optimum conditions for HCII adsorption and desorption were determined. Dermatan Sulfate 4-6 serpin family D member 1 Homo sapiens 103-107 1646210-5 1991 The DS bound to the silica matrix was also tested as a chromatographic support for the purification of HCII from human plasma; the optimum conditions for HCII adsorption and desorption were determined. Dermatan Sulfate 4-6 serpin family D member 1 Homo sapiens 154-158 2045458-1 1991 Heparin cofactor II (HCII) is an inhibitor of thrombin in human plasma whose activity is enhanced by heparin and dermatan sulphate. Dermatan Sulfate 113-130 serpin family D member 1 Homo sapiens 0-19 2045458-1 1991 Heparin cofactor II (HCII) is an inhibitor of thrombin in human plasma whose activity is enhanced by heparin and dermatan sulphate. Dermatan Sulfate 113-130 serpin family D member 1 Homo sapiens 21-25 2045458-7 1991 The HCII activity was evaluated as antithrombin dermatan sulphate cofactor activity. Dermatan Sulfate 48-65 serpin family D member 1 Homo sapiens 4-8 1646210-1 1991 Dermatan sulphate (DS) is a glycosaminoglycan which catalyses specifically thrombin inhibition by a plasmatic inhibitor, Heparin cofactor II (HCII). Dermatan Sulfate 0-17 serpin family D member 1 Homo sapiens 121-140 1646210-1 1991 Dermatan sulphate (DS) is a glycosaminoglycan which catalyses specifically thrombin inhibition by a plasmatic inhibitor, Heparin cofactor II (HCII). Dermatan Sulfate 0-17 serpin family D member 1 Homo sapiens 142-146 1646210-1 1991 Dermatan sulphate (DS) is a glycosaminoglycan which catalyses specifically thrombin inhibition by a plasmatic inhibitor, Heparin cofactor II (HCII). Dermatan Sulfate 19-21 serpin family D member 1 Homo sapiens 121-140 1646210-1 1991 Dermatan sulphate (DS) is a glycosaminoglycan which catalyses specifically thrombin inhibition by a plasmatic inhibitor, Heparin cofactor II (HCII). Dermatan Sulfate 19-21 serpin family D member 1 Homo sapiens 142-146 1671335-1 1991 Heparin cofactor II (HCII) is a 66-kDa plasma glycoprotein that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Dermatan Sulfate 109-125 serpin family D member 1 Homo sapiens 0-19 1671335-1 1991 Heparin cofactor II (HCII) is a 66-kDa plasma glycoprotein that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Dermatan Sulfate 109-125 serpin family D member 1 Homo sapiens 21-25 1646210-2 1991 DS was insolubilized on a silica matrix to study its interaction with HCII. Dermatan Sulfate 0-2 serpin family D member 1 Homo sapiens 70-74 2512688-4 1989 However, HCII caused a marked decrease in the thrombin-stimulated prostacyclin prostacyclin production in the presence of 2 mg/ml dermatan sulfate (DS). Dermatan Sulfate 130-146 serpin family D member 1 Homo sapiens 9-13 2266131-3 1990 Highly specific requirements with respect to the nature of the involved amino acids as well as to their spatial arrangements were found to be crucial for efficient activation of hLS2 by dermatan sulfate. Dermatan Sulfate 186-202 serpin family D member 1 Homo sapiens 178-182 2211700-1 1990 Dermatan sulfate increases the rate of inhibition of thrombin by heparin cofactor II (HCII) approximately 1000-fold by providing a catalytic template to which both the inhibitor and the protease bind. Dermatan Sulfate 0-16 serpin family D member 1 Homo sapiens 65-84 2211700-1 1990 Dermatan sulfate increases the rate of inhibition of thrombin by heparin cofactor II (HCII) approximately 1000-fold by providing a catalytic template to which both the inhibitor and the protease bind. Dermatan Sulfate 0-16 serpin family D member 1 Homo sapiens 86-90 2211700-4 1990 To characterize the HCII-binding site in dermatan sulfate, we isolated the smallest fragment of dermatan sulfate that bound to HCII with high affinity. Dermatan Sulfate 41-57 serpin family D member 1 Homo sapiens 20-24 2211700-4 1990 To characterize the HCII-binding site in dermatan sulfate, we isolated the smallest fragment of dermatan sulfate that bound to HCII with high affinity. Dermatan Sulfate 41-57 serpin family D member 1 Homo sapiens 127-131 2211700-4 1990 To characterize the HCII-binding site in dermatan sulfate, we isolated the smallest fragment of dermatan sulfate that bound to HCII with high affinity. Dermatan Sulfate 96-112 serpin family D member 1 Homo sapiens 20-24 2211700-4 1990 To characterize the HCII-binding site in dermatan sulfate, we isolated the smallest fragment of dermatan sulfate that bound to HCII with high affinity. Dermatan Sulfate 96-112 serpin family D member 1 Homo sapiens 127-131 2122537-0 1990 Heparin cofactor II inhibits thrombin-stimulated release of tissue plasminogen activator from cultured human endothelial cells in the presence of dermatan sulfate. Dermatan Sulfate 146-162 serpin family D member 1 Homo sapiens 0-19 2122537-3 1990 In contrast, in the presence of dermatan sulfate, HC II inhibited thrombin stimulation of t-PA:Ag release more strongly than AT III did. Dermatan Sulfate 32-48 serpin family D member 1 Homo sapiens 50-55 2122537-6 1990 Based on these results, it was suggested that HC II may inhibit an increase in fibrinolytic activity mediated by thrombin-stimulated endothelial cells in the liquid phase through a suppression of thrombin stimulation of t-PA:Ag release, when plasma is exposed to vascular smooth muscle cells or fibroblasts which synthesize a significant amount of dermatan sulfate. Dermatan Sulfate 348-364 serpin family D member 1 Homo sapiens 46-51 2028443-2 1991 Also when dermatan sulfate which does not enhance the action of AT III is used for the activation of HC II there is a considerable influence on the remaining thrombin activity which alters the test results. Dermatan Sulfate 10-26 serpin family D member 1 Homo sapiens 101-106 2196322-2 1990 A role for HCII as an inhibitor of thrombin in the presence of dermatan sulfate and heparin has been proposed. Dermatan Sulfate 63-79 serpin family D member 1 Homo sapiens 11-15 2512688-4 1989 However, HCII caused a marked decrease in the thrombin-stimulated prostacyclin prostacyclin production in the presence of 2 mg/ml dermatan sulfate (DS). Dermatan Sulfate 148-150 serpin family D member 1 Homo sapiens 9-13 2512688-5 1989 The significant inhibition by HCII occurred when the DS concentrations were 0.2 microgram/ml and higher. Dermatan Sulfate 53-55 serpin family D member 1 Homo sapiens 30-34 2512688-6 1989 From these results we suggest that HCII may prevent a prostacyclin-induced inhibition of platelet aggregation for hemostasis when plasma is exposed to vascular smooth muscle cells or fibroblasts which synthesize a significant amount of DS. Dermatan Sulfate 236-238 serpin family D member 1 Homo sapiens 35-39 3691797-0 1987 Binding of heparin or dermatan sulfate to thrombin is essential for the sulfated polysaccharide-accelerated inhibition of thrombin by heparin cofactor II. Dermatan Sulfate 22-38 serpin family D member 1 Homo sapiens 134-153 3348170-2 1988 Functional assays for heparin cofactor II (HC-II) are based on the inactivation of thrombin by HC-II in the presence of dermatan sulfate (DS). Dermatan Sulfate 120-136 serpin family D member 1 Homo sapiens 22-41 3348170-2 1988 Functional assays for heparin cofactor II (HC-II) are based on the inactivation of thrombin by HC-II in the presence of dermatan sulfate (DS). Dermatan Sulfate 120-136 serpin family D member 1 Homo sapiens 43-48 3348170-2 1988 Functional assays for heparin cofactor II (HC-II) are based on the inactivation of thrombin by HC-II in the presence of dermatan sulfate (DS). Dermatan Sulfate 138-140 serpin family D member 1 Homo sapiens 22-41 3348170-2 1988 Functional assays for heparin cofactor II (HC-II) are based on the inactivation of thrombin by HC-II in the presence of dermatan sulfate (DS). Dermatan Sulfate 138-140 serpin family D member 1 Homo sapiens 43-48 2894851-1 1988 Heparin cofactor II (HCII) is an inhibitor of thrombin in plasma that is activated by dermatan sulfate or heparin. Dermatan Sulfate 86-102 serpin family D member 1 Homo sapiens 0-19 2894851-1 1988 Heparin cofactor II (HCII) is an inhibitor of thrombin in plasma that is activated by dermatan sulfate or heparin. Dermatan Sulfate 86-102 serpin family D member 1 Homo sapiens 21-25 2894851-11 1988 The recombinant HCII formed a complex with 125I-thrombin in a reaction that required the presence of heparin or dermatan sulfate. Dermatan Sulfate 112-128 serpin family D member 1 Homo sapiens 16-20 2713501-2 1989 An in vivo role for thrombin (IIa) inhibition by HCII in the presence of certain glycosaminoglycans (dermatan sulfate and heparin) can be proposed. Dermatan Sulfate 101-117 serpin family D member 1 Homo sapiens 49-53 3217919-2 1988 DS accelerates thrombin inhibition by heparin cofactor II (HC II). Dermatan Sulfate 0-2 serpin family D member 1 Homo sapiens 38-57 3217919-2 1988 DS accelerates thrombin inhibition by heparin cofactor II (HC II). Dermatan Sulfate 0-2 serpin family D member 1 Homo sapiens 59-64 3691797-5 1987 These results indicate that the binding of heparin or dermatan sulfate to both thrombin and HC II is required for the sulfated polysaccharide-dependent acceleration of the thrombin inhibition by HC II, and the binding to thrombin is more essential for the reaction. Dermatan Sulfate 54-70 serpin family D member 1 Homo sapiens 195-200 3691797-1 1987 Heparin cofactor II (HC II) and thrombin were chemically modified with pyridoxal 5"-phosphate, and their effects on the inhibition of thrombin by HC II in the presence of heparin or dermatan sulfate were studied. Dermatan Sulfate 182-198 serpin family D member 1 Homo sapiens 0-19 3691797-2 1987 The inhibition of thrombin by HC II was enhanced about 7000-fold in the presence of heparin or dermatan sulfate. Dermatan Sulfate 95-111 serpin family D member 1 Homo sapiens 30-35 3691797-5 1987 These results indicate that the binding of heparin or dermatan sulfate to both thrombin and HC II is required for the sulfated polysaccharide-dependent acceleration of the thrombin inhibition by HC II, and the binding to thrombin is more essential for the reaction. Dermatan Sulfate 54-70 serpin family D member 1 Homo sapiens 92-97 3301469-5 1987 Dermatan sulphate, a glycosaminoglycan, specifically activates HCII and increases its thrombin neutralizing activity by over a thousand fold. Dermatan Sulfate 0-17 serpin family D member 1 Homo sapiens 63-67 3619144-11 1987 In contrast, the anticoagulant effect of dermatan sulfate is strictly dependent on HC II. Dermatan Sulfate 41-57 serpin family D member 1 Homo sapiens 83-88 3793724-1 1987 Inhibition of thrombin by heparin cofactor II (HCII) is accelerated by dermatan sulfate, heparan sulfate, and heparin. Dermatan Sulfate 71-87 serpin family D member 1 Homo sapiens 26-45 3793724-1 1987 Inhibition of thrombin by heparin cofactor II (HCII) is accelerated by dermatan sulfate, heparan sulfate, and heparin. Dermatan Sulfate 71-87 serpin family D member 1 Homo sapiens 47-51 3793724-6 1987 In contrast, treatment with chondroitinase ABC almost totally abolished the ability of these cells to activate HCII while chondroitinase AC had little or no effect, suggesting that dermatan sulfate was responsible for the activity observed. Dermatan Sulfate 181-197 serpin family D member 1 Homo sapiens 111-115 3619144-4 1987 Dermatan sulfate and pentosan sulfate but not heparin sulfate increase the rate of thrombin inhibition by HC II. Dermatan Sulfate 0-16 serpin family D member 1 Homo sapiens 106-111 3301469-10 1987 The specificity of dermatan sulphate for HCII has allowed the development of functional assays for this protein. Dermatan Sulfate 19-36 serpin family D member 1 Homo sapiens 41-45 2432917-4 1986 The anticoagulant activities of heparin and dermatan sulphate were primarily attributable to their ability to enhance thrombin inhibition by AT III and HC II respectively. Dermatan Sulfate 44-61 serpin family D member 1 Homo sapiens 152-157 4041618-1 1985 Heparin cofactor II (HCII) is a glycoprotein in human plasma which inactivates thrombin rapidly in the presence of heparin or dermatan sulfate. Dermatan Sulfate 126-142 serpin family D member 1 Homo sapiens 0-19 3755134-2 1986 To determine the minimum structure of dermatan sulfate required to activate HCII, the glycosaminoglycan was partially degraded by sequential treatment with periodate, [3H]borohydride, and sulfuric acid. Dermatan Sulfate 38-54 serpin family D member 1 Homo sapiens 76-80 3755134-7 1986 Fragments of dermatan sulfate containing a minimum of 12-14 sugar residues accelerated inhibition of thrombin by HCII. Dermatan Sulfate 13-29 serpin family D member 1 Homo sapiens 113-117 3755134-9 1986 These studies suggest that HCII is activated by dermatan sulfate fragments greater than or equal to 12 residues in length that contain a specific octasaccharide sequence required for binding to the inhibitor. Dermatan Sulfate 48-64 serpin family D member 1 Homo sapiens 27-31 3841420-4 1985 The biological activity of the HC II was unchanged after labelling as was its migratory pattern by crossed immunoelectrophoresis in the presence of heparin or dermatan sulfate. Dermatan Sulfate 159-175 serpin family D member 1 Homo sapiens 31-36 3755134-1 1986 Heparin cofactor II (HCII) inhibits thrombin rapidly in human plasma in the presence of heparin or dermatan sulfate. Dermatan Sulfate 99-115 serpin family D member 1 Homo sapiens 0-19 3755134-1 1986 Heparin cofactor II (HCII) inhibits thrombin rapidly in human plasma in the presence of heparin or dermatan sulfate. Dermatan Sulfate 99-115 serpin family D member 1 Homo sapiens 21-25 2998359-1 1985 Human plasma heparin cofactor II (HCII) inhibits thrombin by rapidly forming a stable, equimolar complex in the presence of heparin or dermatan sulfate. Dermatan Sulfate 135-151 serpin family D member 1 Homo sapiens 13-32 2998359-1 1985 Human plasma heparin cofactor II (HCII) inhibits thrombin by rapidly forming a stable, equimolar complex in the presence of heparin or dermatan sulfate. Dermatan Sulfate 135-151 serpin family D member 1 Homo sapiens 34-38 4041618-1 1985 Heparin cofactor II (HCII) is a glycoprotein in human plasma which inactivates thrombin rapidly in the presence of heparin or dermatan sulfate. Dermatan Sulfate 126-142 serpin family D member 1 Homo sapiens 21-25 4041618-2 1985 We have developed a functional assay for HCII in which inhibition of thrombin by plasma is determined in the presence of dermatan sulfate. Dermatan Sulfate 121-137 serpin family D member 1 Homo sapiens 41-45 6084876-8 1984 When mixed with thrombin in the presence of dermatan sulfate, normal human plasma showed antithrombin activity which was not due to AT III but to HC II only. Dermatan Sulfate 44-60 serpin family D member 1 Homo sapiens 146-151 3838315-3 1985 In the presence of 67 micrograms/ml of dermatan sulfate, radioactivity was detected in a band which corresponded to the thrombin-HCII complex (Mr = 96,000) upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Dermatan Sulfate 39-55 serpin family D member 1 Homo sapiens 129-133 3838315-7 1985 HCII inhibited leukocyte cathepsin G slowly, with a rate constant of 8 X 10(4) M-1 min-1 in the presence of dermatan sulfate. Dermatan Sulfate 108-124 serpin family D member 1 Homo sapiens 0-4 3838315-8 1985 These results indicate that the protease specificity of HCII is more restricted than that of other plasma protease inhibitors and suggest that the anticoagulant effect of dermatan sulfate is due solely to inhibition of thrombin by HCII. Dermatan Sulfate 171-187 serpin family D member 1 Homo sapiens 56-60 3838315-8 1985 These results indicate that the protease specificity of HCII is more restricted than that of other plasma protease inhibitors and suggest that the anticoagulant effect of dermatan sulfate is due solely to inhibition of thrombin by HCII. Dermatan Sulfate 171-187 serpin family D member 1 Homo sapiens 231-235 6687888-5 1983 The second order rate constant for the thrombin-HCII reaction reached a maximum value of 6.4 X 10(8) M-1 min-1 in the presence of 250-500 micrograms/ml of dermatan sulfate compared to 3.8 X 10(8) M-1 min-1 in the presence of 40-80 micrograms/ml of heparin. Dermatan Sulfate 155-171 serpin family D member 1 Homo sapiens 48-52 6395434-3 1984 HCII activity was then determined by measuring the rate of human thrombin inhibition by 3 ways: a) activation with heparin in AT-free plasma, b) activation with dermatan sulfate in normal plasma and c) activation with dermatan sulfate in AT-free plasma. Dermatan Sulfate 161-177 serpin family D member 1 Homo sapiens 0-4 6395434-3 1984 HCII activity was then determined by measuring the rate of human thrombin inhibition by 3 ways: a) activation with heparin in AT-free plasma, b) activation with dermatan sulfate in normal plasma and c) activation with dermatan sulfate in AT-free plasma. Dermatan Sulfate 218-234 serpin family D member 1 Homo sapiens 0-4 6687888-0 1983 Activation of heparin cofactor II by dermatan sulfate. Dermatan Sulfate 37-53 serpin family D member 1 Homo sapiens 14-33 6687888-2 1983 Heparin, dermatan sulfate, and heparan sulfate from bovine liver (in order of decreasing activity) activated HCII. Dermatan Sulfate 9-25 serpin family D member 1 Homo sapiens 109-113