PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9362376-1 1997 Recently, we developed a series of cluster mannosides that were able to inhibit tissue-type plasminogen activator (t-PA) binding to the isolated mannose receptor. Mannosides 43-53 plasminogen activator, tissue type Homo sapiens 80-113 9362376-7 1997 The concentrations of mannoside necessary to inhibit 125I-t-PA degradation in vitro were comparable with the concentrations necessary to inhibit mannose receptor-mediated 125I-t-PA clearance in vivo. Mannosides 22-31 plasminogen activator, tissue type Homo sapiens 58-62 9362376-1 1997 Recently, we developed a series of cluster mannosides that were able to inhibit tissue-type plasminogen activator (t-PA) binding to the isolated mannose receptor. Mannosides 43-53 plasminogen activator, tissue type Homo sapiens 115-119 9362376-3 1997 To test whether these mannosides would also be efficient inhibitors in humans, we studied the expression of the mannose receptor in the human liver and determined the efficacy of the mannosides to inhibit mannose receptor-mediated t-PA degradation by both rat and human cells. Mannosides 22-32 plasminogen activator, tissue type Homo sapiens 231-235 9362376-3 1997 To test whether these mannosides would also be efficient inhibitors in humans, we studied the expression of the mannose receptor in the human liver and determined the efficacy of the mannosides to inhibit mannose receptor-mediated t-PA degradation by both rat and human cells. Mannosides 183-193 plasminogen activator, tissue type Homo sapiens 231-235 9362376-6 1997 The cluster mannoside with six mannose residues connected with a backbone of five lysine groups (M6L5) was, like unlabeled t-PA, able to inhibit 125I-t-PA degradation in the nmol/L range, while the mannoside M5L4 inhibited 125I-t-PA degradation in the micromol/L range. Mannosides 12-21 plasminogen activator, tissue type Homo sapiens 123-127 9362376-6 1997 The cluster mannoside with six mannose residues connected with a backbone of five lysine groups (M6L5) was, like unlabeled t-PA, able to inhibit 125I-t-PA degradation in the nmol/L range, while the mannoside M5L4 inhibited 125I-t-PA degradation in the micromol/L range. Mannosides 12-21 plasminogen activator, tissue type Homo sapiens 150-154 9362376-6 1997 The cluster mannoside with six mannose residues connected with a backbone of five lysine groups (M6L5) was, like unlabeled t-PA, able to inhibit 125I-t-PA degradation in the nmol/L range, while the mannoside M5L4 inhibited 125I-t-PA degradation in the micromol/L range. Mannosides 12-21 plasminogen activator, tissue type Homo sapiens 150-154