PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34246414-4 2022 Because it is modular, the assay can monitor the impact of different cellular components, such as heparan sulfate, lipids, and membrane proteins on the RBD-ACE2 interaction and it can be extended to the full-length spike protein. Heparitin Sulfate 98-113 angiotensin converting enzyme 2 Homo sapiens 156-160 34196550-2 2021 The attachment of heparan sulfate (HS) to S-pro is necessary for its binding to ACE2. Heparitin Sulfate 18-33 angiotensin converting enzyme 2 Homo sapiens 80-84 34196550-2 2021 The attachment of heparan sulfate (HS) to S-pro is necessary for its binding to ACE2. Heparitin Sulfate 35-37 angiotensin converting enzyme 2 Homo sapiens 80-84 33915212-10 2021 Heparin-binding to the open conformation of spike structurally supports the state and may aid ACE2 binding as reported with cell surface-bound heparan sulfate. Heparitin Sulfate 143-158 angiotensin converting enzyme 2 Homo sapiens 94-98 34179075-2 2021 Cellular heparan sulfate (HS) has been found to bind SARS-CoV-2 spike protein (SV2-S) and co-operate with cell surface receptor angiotensin-converting enzyme 2 (ACE2) to mediate SARS-CoV-2 infection of host cells. Heparitin Sulfate 9-24 angiotensin converting enzyme 2 Homo sapiens 128-159 34179075-2 2021 Cellular heparan sulfate (HS) has been found to bind SARS-CoV-2 spike protein (SV2-S) and co-operate with cell surface receptor angiotensin-converting enzyme 2 (ACE2) to mediate SARS-CoV-2 infection of host cells. Heparitin Sulfate 9-24 angiotensin converting enzyme 2 Homo sapiens 161-165 35060381-1 2022 The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor for human angiotensin-converting enzyme 2 (ACE2) for recognizing the receptor-binding domain (RBD) of the spike (S) protein on the surface of the virion. Heparitin Sulfate 119-135 angiotensin converting enzyme 2 Homo sapiens 195-226 35060381-1 2022 The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor for human angiotensin-converting enzyme 2 (ACE2) for recognizing the receptor-binding domain (RBD) of the spike (S) protein on the surface of the virion. Heparitin Sulfate 119-135 angiotensin converting enzyme 2 Homo sapiens 228-232 33514685-0 2021 Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection. Heparitin Sulfate 21-36 angiotensin converting enzyme 2 Homo sapiens 85-89 33851732-5 2021 In addition to ACE2, several recent studies have implicated the crucial role cell surface heparan sulfate (HS) as a necessary assisting co-factor for ACE2-mediated SARS-CoV-2 entry. Heparitin Sulfate 90-105 angiotensin converting enzyme 2 Homo sapiens 150-154 33851732-5 2021 In addition to ACE2, several recent studies have implicated the crucial role cell surface heparan sulfate (HS) as a necessary assisting co-factor for ACE2-mediated SARS-CoV-2 entry. Heparitin Sulfate 107-109 angiotensin converting enzyme 2 Homo sapiens 150-154 33173010-4 2021 In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells. Heparitin Sulfate 167-182 angiotensin converting enzyme 2 Homo sapiens 72-103 33173010-4 2021 In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells. Heparitin Sulfate 167-182 angiotensin converting enzyme 2 Homo sapiens 105-110 32992731-2 2020 Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans. Heparitin Sulfate 332-347 angiotensin converting enzyme 2 Homo sapiens 53-84 32970989-2 2020 Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site. Heparitin Sulfate 34-49 angiotensin converting enzyme 2 Homo sapiens 79-83 32970989-7 2020 We suggest a model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2. Heparitin Sulfate 68-83 angiotensin converting enzyme 2 Homo sapiens 120-124 33298900-2 2020 Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry. Heparitin Sulfate 139-154 angiotensin converting enzyme 2 Homo sapiens 71-75 33298900-2 2020 Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry. Heparitin Sulfate 156-158 angiotensin converting enzyme 2 Homo sapiens 71-75 32992731-2 2020 Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans. Heparitin Sulfate 332-347 angiotensin converting enzyme 2 Homo sapiens 86-90 32577638-4 2020 In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells. Heparitin Sulfate 167-182 angiotensin converting enzyme 2 Homo sapiens 72-103 32699847-3 2020 Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs). Heparitin Sulfate 170-185 angiotensin converting enzyme 2 Homo sapiens 107-111 32699847-3 2020 Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs). Heparitin Sulfate 270-285 angiotensin converting enzyme 2 Homo sapiens 107-111 32699853-2 2020 Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the domain that binds to ACE2. Heparitin Sulfate 43-58 angiotensin converting enzyme 2 Homo sapiens 109-113 32699853-6 2020 These findings support a model for SARS-CoV-2 infection in which viral attachment and infection involves formation of a complex between heparan sulfate and ACE2. Heparitin Sulfate 136-151 angiotensin converting enzyme 2 Homo sapiens 156-160 32577638-4 2020 In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells. Heparitin Sulfate 167-182 angiotensin converting enzyme 2 Homo sapiens 105-110