PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10378377-9	1999	These findings indicate that tau deposits are antigenically similar in several neurodegenerative diseases and that tau staining is often associated with heparan sulphate staining, supporting the concept that heparan sulphate may be involved in the assembly of tau protein into filaments.	Heparitin Sulfate	208-224	microtubule associated protein tau	Homo sapiens	29-32	
10378377-9	1999	These findings indicate that tau deposits are antigenically similar in several neurodegenerative diseases and that tau staining is often associated with heparan sulphate staining, supporting the concept that heparan sulphate may be involved in the assembly of tau protein into filaments.	Heparitin Sulfate	208-224	microtubule associated protein tau	Homo sapiens	115-118	
10378377-9	1999	These findings indicate that tau deposits are antigenically similar in several neurodegenerative diseases and that tau staining is often associated with heparan sulphate staining, supporting the concept that heparan sulphate may be involved in the assembly of tau protein into filaments.	Heparitin Sulfate	208-224	microtubule associated protein tau	Homo sapiens	115-118	
35525272-2	2022	This begins with tau binding to cell surface heparan sulfate proteoglycans, which triggers macropinocytosis.	Heparitin Sulfate	45-60	microtubule associated protein tau	Homo sapiens	17-20	
9108114-6	1997	Moreover, tau immunoreactivity coexists with heparan sulfate in affected nerve and glial cells.	Heparitin Sulfate	45-60	microtubule associated protein tau	Homo sapiens	10-13	
8849730-5	1996	Here we show that non-phosphorylated recombinant tau isoforms with three microtubule-binding repeats form paired helical-like filaments under physiological conditions in vitro, when incubated with sulphated glycosaminoglycans such as heparin or heparan sulphate.	Heparitin Sulfate	245-261	microtubule associated protein tau	Homo sapiens	49-52	
35040015-0	2022	Heparan Sulfate Proteoglycans (HSPGs) Serve as the Mediator Between Monomeric Tau and Its Subsequent Intracellular ERK1/2 Pathway Activation.	Heparitin Sulfate	0-15	microtubule associated protein tau	Homo sapiens	78-81	
29752409-2	2018	We previously reported that tau and alpha-synuclein aggregates bind heparan sulfate proteoglycans (HSPGs) on the cell surface, promoting cellular uptake and intracellular seeding.	Heparitin Sulfate	68-83	microtubule associated protein tau	Homo sapiens	28-31	
31391090-8	2019	We determined a novel mode of action of a therapeutic candidate antibody, which potently inhibits neuronal internalization of AD tau species by masking of epitopes present in MTBD important for interaction with neuron surface Heparan Sulfate Proteoglycans (HSPGs).	Heparitin Sulfate	226-241	microtubule associated protein tau	Homo sapiens	129-132	
12878436-4	2003	Heparan sulphate proteoglycans may promote amyloid-beta peptide (Abeta) or tau fibrillisation on the one hand, and provide resistance against proteolytic breakdown on the other.	Heparitin Sulfate	0-16	microtubule associated protein tau	Homo sapiens	75-78	
29686391-0	2018	Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).	Heparitin Sulfate	53-68	microtubule associated protein tau	Homo sapiens	0-3	
29686391-4	2018	Using CRISPRi technology we have tested 3200 genes for their ability to regulate tau entry and identified enzymes in the heparan sulfate proteoglycan biosynthetic pathway as key regulators.	Heparitin Sulfate	121-136	microtubule associated protein tau	Homo sapiens	81-84	
28387673-1	2017	BACKGROUND: Heparan sulfate proteoglycans (HSPGs) promote amyloid-beta peptide and tau fibrillization in Alzheimer"s disease (AD) and provide resistance against proteolytic breakdown.	Heparitin Sulfate	12-27	microtubule associated protein tau	Homo sapiens	83-86	
26126828-6	2015	Antibody-independent Tau uptake into BV2 cells was blocked by heparin, consistent with a previously described role for heparan sulfate proteoglycans.	Heparitin Sulfate	119-134	microtubule associated protein tau	Homo sapiens	21-24	
25842390-7	2015	We showed, in vitro, that the 3-O-sulphated heparan sulphates bind to tau, but not to GSK3B, protein kinase A or protein phosphatase 2, inducing its abnormal phosphorylation.	Heparitin Sulfate	44-61	microtubule associated protein tau	Homo sapiens	70-73	
25842390-10	2015	By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau.	Heparitin Sulfate	70-87	microtubule associated protein tau	Homo sapiens	20-23	
25842390-10	2015	By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau.	Heparitin Sulfate	70-87	microtubule associated protein tau	Homo sapiens	182-185	
15211644-1	2004	Accumulating evidence indicates that the heparan-sulfate-proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer"s disease (AD).	Heparitin Sulfate	41-56	microtubule associated protein tau	Homo sapiens	166-169