PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33672694-2 2021 The ability of human topoisomerase I (hTOPI) and II to relax supercoiled plasmid DNA in the presence of various concentrations of the tacrine-coumarin hybrid molecules was studied with agarose gel electrophoresis. Sepharose 185-192 DNA topoisomerase I Homo sapiens 38-43 26722447-2 2015 METHODS: This study investigated the inhibitory effect of isoliquiritigenin on the growth of U87 glioma cells and its cytotoxicity by MTT method and determined the effect of isoliquiritigenin on TOP I activity by agarose gel electrophoresis. Sepharose 213-220 DNA topoisomerase I Homo sapiens 195-200 26722447-6 2015 Agarose gel electrophoresis showed that isoliquiritigenin had significant inhibitory effect on TOP I activity. Sepharose 0-7 DNA topoisomerase I Homo sapiens 95-100