PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17243915-4 2007 The aim of this study was to investigate whether plasma concentrations of interleukin-6, interleukin-8, C-reactive protein, and monocyte chemoattractant protein-1 are increased with higher plasma homocysteine concentrations and whether decreasing homocysteine by vitamin supplementation decreases the concentration of these markers. Homocysteine 196-208 C-reactive protein Homo sapiens 104-122 18203326-16 2008 Lipoprotein(a) [Lp(a)] also correlated with rheumatoid factor (RF) and C-reactive protein (CRP); homocysteine (HCy) correlated with CRP and correlated inversely with folate and vitamin B12 production. Homocysteine 97-109 C-reactive protein Homo sapiens 132-135 18203326-16 2008 Lipoprotein(a) [Lp(a)] also correlated with rheumatoid factor (RF) and C-reactive protein (CRP); homocysteine (HCy) correlated with CRP and correlated inversely with folate and vitamin B12 production. Homocysteine 111-114 C-reactive protein Homo sapiens 132-135 17328057-4 2007 RESULTS: At baseline, an elevated C-reactive protein (CRP) level correlated positively with lipoprotein(a) (Lp[a]), intercellular adhesion molecule 1, interleukin-6, and homocysteine levels but was inversely correlated with concentrations of all other lipid moieties and sex hormone binding globulin (SHBG). Homocysteine 170-182 C-reactive protein Homo sapiens 34-52 17328057-4 2007 RESULTS: At baseline, an elevated C-reactive protein (CRP) level correlated positively with lipoprotein(a) (Lp[a]), intercellular adhesion molecule 1, interleukin-6, and homocysteine levels but was inversely correlated with concentrations of all other lipid moieties and sex hormone binding globulin (SHBG). Homocysteine 170-182 C-reactive protein Homo sapiens 54-57 16319543-10 2005 The association between C-reactive protein and disease was U-shaped and a graded association existed between homocysteine, cysteine, von Willebrand factor and disease. Homocysteine 109-121 C-reactive protein Homo sapiens 24-42 17051744-4 2006 RESULTS: The level of homocysteine showed statistically significant negative linear correlation with HDL-cholesterol and the anti-atherogenic ApoAI, and showed a positive correlation with CRP and FXIII activities in the entire patient population. Homocysteine 22-34 C-reactive protein Homo sapiens 188-191 16690736-3 2006 RESULTS: According to multiple linear regression analysis, C-reactive protein and interleukin-6 receptor were strongly and negatively associated with circulating vitamin B6 but not with folate concentrations, independent of age, sex, serum creatinine, serum albumin, total energy intake, smoking history, dietary nutrient intake, and circulating homocysteine and vitamin concentrations. Homocysteine 346-358 C-reactive protein Homo sapiens 59-77 16607071-4 2006 The odds ratio for myocardial infarction increased progressively across the four quarters of the homocysteine distribution, after adjusting for only age and sex or for the full adjustment (age, sex, smoking, systolic blood pressure, total cholesterol, fibrinogen, C-reactive protein and interleukin-6). Homocysteine 97-109 C-reactive protein Homo sapiens 264-282 16755160-12 2006 Stepwise regression analysis demonstrated that baseline homocysteine levels were related to folate (coefficient: -1.02; F: 64.5), creatinine (coefficient: 0.98; F: 11.3), and C reactive protein (coefficient: -0.64; F: 4.3). Homocysteine 56-68 C-reactive protein Homo sapiens 175-193 16464786-5 2006 The aim of this study was to investigate whether individuals with increased plasma homocysteine concentrations have altered levels of serum CRP and IL-6. Homocysteine 83-95 C-reactive protein Homo sapiens 140-143 18229569-9 2007 CONCLUSIONS: Plasma homocysteine is significantly elevated in COPD patients relative to age and sex-matched controls and is related to serum CRP and COPD severity. Homocysteine 20-32 C-reactive protein Homo sapiens 141-144 17006323-6 2006 Similarly, cardiac transplant patients yielded a significantly elevated C-reactive protein (CRP) (4.11+/-6.25 [transplant group (TX)] vs. 2.09+/-2.21 mg/L [control group (CTL)]; P=0.0195), and homocysteine (19.2+/-8.8 [TX] vs. 9.70+/-2.45 microM [CTL]; P<0.001). Homocysteine 193-205 C-reactive protein Homo sapiens 92-95 16875126-4 2006 The level of homocysteine is directly related to coronary heart disease (OR 9.2, 95% CI 2.3 to 21), stroke with major neurological deficit (OR 10.4, 95% CI 1.1 to 50), the level of creatinine (OR 4.6, 95 CI 1.1 to 10), and C-reactive protein (OR 3.2, 95% CI 0.9 to 15). Homocysteine 13-25 C-reactive protein Homo sapiens 223-241 14656034-8 2003 The odds ratios were calculated continuously for homocysteine in dependence on C-reactive protein. Homocysteine 49-61 C-reactive protein Homo sapiens 79-97 15704253-0 2004 Homocysteine in relation to C-reactive protein and low-density lipoprotein cholesterol in assessment of cardiovascular risk. Homocysteine 0-12 C-reactive protein Homo sapiens 28-46 15704253-2 2004 We investigated the predictive value of homocysteine (Hcy) in relation to C-reactive protein (CRP) and low-density lipoprotein (LDL)-cholesterol in patients with confirmed coronary disease. Homocysteine 40-52 C-reactive protein Homo sapiens 74-92 15704253-2 2004 We investigated the predictive value of homocysteine (Hcy) in relation to C-reactive protein (CRP) and low-density lipoprotein (LDL)-cholesterol in patients with confirmed coronary disease. Homocysteine 40-52 C-reactive protein Homo sapiens 94-97 15704253-2 2004 We investigated the predictive value of homocysteine (Hcy) in relation to C-reactive protein (CRP) and low-density lipoprotein (LDL)-cholesterol in patients with confirmed coronary disease. Homocysteine 54-57 C-reactive protein Homo sapiens 74-92 15704253-9 2004 The results emphasize that detemination of Hcy may improve the predictive value of C-reactive protein and the LDL-cholesterol. Homocysteine 43-46 C-reactive protein Homo sapiens 83-101 15770053-6 2004 There was a significant positive relation (r = 0.384, p < 0.001) between the levels of plasma Hcy and serum CRP in HD and CAPD patients. Homocysteine 97-100 C-reactive protein Homo sapiens 111-114 15332580-5 2004 A statistically significant correlation exists between homocysteine serum levels and acute phase proteins (C-reactive protein, fibrinogen) in patients with unstable angina. Homocysteine 55-67 C-reactive protein Homo sapiens 107-125 15931619-6 2005 Elevated plasma Hcy levels correlated significantly with serum IL-6 ( r = 0.25, P < .001), C-peptide ( r = 0.22, P < .01), and the number of abnormal metabolic factors ( r = 0.20, P < .01), but not with C-reactive protein. Homocysteine 16-19 C-reactive protein Homo sapiens 212-230 14656034-11 2003 The continuously calculated odds ratio for homocysteine demonstrated a distinct influence of C-reactive protein. Homocysteine 43-55 C-reactive protein Homo sapiens 93-111 14656034-12 2003 In the group with high C-reactive protein levels, homocysteine levels above 9.6 micromol/l resulted in a markedly elevated risk (odds ratio 12), in the group with C-reactive protein levels below 5 mg/dl, a comparable risk increase was observed at a homocysteine level of 16.6 micromol/l. Homocysteine 50-62 C-reactive protein Homo sapiens 23-41 14656034-13 2003 This data strongly suggests that plasma homocysteine helps identify individuals at risk, especially among those with elevated C-reactive protein levels. Homocysteine 40-52 C-reactive protein Homo sapiens 126-144 15147103-6 2003 Homocysteine was associated with increased anger (anger-suppression and anger-experience), psychological parameters associated with cardiovascular disease and also mildly elevated CRP and homocysteine levels. Homocysteine 0-12 C-reactive protein Homo sapiens 180-183 12921979-6 2003 CRP correlated significantly to other CHD risk factors like body mass index (BMI), systolic blood pressure, diastolic blood pressure, plasma fibrinogen, serum high-density lipoprotein cholesterol, plasma homocysteine, and serum triglycerides. Homocysteine 204-216 C-reactive protein Homo sapiens 0-3 12641538-9 2003 CONCLUSIONS: Homocysteine-lowering vitamin treatment in healthy siblings of patients with premature atherosclerotic disease is associated with a decreased urinary albumin-to-creatinine ratio, but not with other markers of endothelial dysfunction, or in plasma C-reactive protein. Homocysteine 13-25 C-reactive protein Homo sapiens 260-278 34570274-10 2021 Hcy level was negatively correlated with folate (p = 0.009) and vitamin B12 level (p = 0.02) and positively with age (p = 0.01), C-reactive protein (CRP; p = 0.05), and Simplified Disease Activity Index (SDAI; p = 0.03). Homocysteine 0-3 C-reactive protein Homo sapiens 129-147 11250957-3 2001 OBJECTIVE: To examine variations in plasma homocysteine concentration in relation to C reactive protein (CRP) in patients presenting with acute coronary syndromes. Homocysteine 43-55 C-reactive protein Homo sapiens 85-103 11250957-3 2001 OBJECTIVE: To examine variations in plasma homocysteine concentration in relation to C reactive protein (CRP) in patients presenting with acute coronary syndromes. Homocysteine 43-55 C-reactive protein Homo sapiens 105-108 10569656-4 1999 There were significant positive associations between CRP levels and age, number of cigarettes smoked per day, body mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, lipoprotein(a), apolipoprotein B, tissue-type plasminogen activator antigen, D-dimers, total homocysteine, and fibrinogen (all p values <0.05). Homocysteine 293-305 C-reactive protein Homo sapiens 53-56 10569656-6 1999 In multivariate analysis, age, smoking status, and serum levels of tissue-type plasminogen activator antigen, fibrinogen, lipoprotein(a), and total homocysteine were independent correlates of CRP levels. Homocysteine 148-160 C-reactive protein Homo sapiens 192-195 15058015-2 2003 The aim of the study was to assess the potential relationships between homocysteine and CRP levels and lipid coronary risk factors in men and women with diabetes. Homocysteine 71-83 C-reactive protein Homo sapiens 88-91 11342801-1 2001 In the past year, evidence from epidemiological studies in patients with renal disease has confirmed associations between both elevated plasma total homocysteine concentrations and the inflammatory marker C-reactive protein with an increased risk of arteriosclerotic vascular disease. Homocysteine 149-161 C-reactive protein Homo sapiens 205-223 10982535-0 2000 Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease. Homocysteine 7-19 C-reactive protein Homo sapiens 85-103 34570274-10 2021 Hcy level was negatively correlated with folate (p = 0.009) and vitamin B12 level (p = 0.02) and positively with age (p = 0.01), C-reactive protein (CRP; p = 0.05), and Simplified Disease Activity Index (SDAI; p = 0.03). Homocysteine 0-3 C-reactive protein Homo sapiens 149-152 35077066-13 2022 Increased CRP was associated with elevated hs-CRP in 3 months after discharge and elevated homocysteine levels in both groups, indicating the persistence of prolonged inflammatory vascular reaction in patients after SARS-CoV-2 associated pneumonia, more pronounced in group 2 patients. Homocysteine 91-103 C-reactive protein Homo sapiens 10-13 28540883-0 2017 The relationship between serum homocysteine and highly sensitive C- reactive protein levels in children on regular hemodialysis. Homocysteine 31-43 C-reactive protein Homo sapiens 65-84 33616345-9 2021 CRP was positively correlated with HOMA-IR, TC, and AHSG (r = 0.485, 0.331, 0.226, p < 0.05), negatively associated with 25-OH-VD (r = -0.443, p < 0.05), and had no correlation to TG and Hcy (r = 0.019, 0.058, p > 0.05). Homocysteine 187-190 C-reactive protein Homo sapiens 0-3 32717709-7 2020 Our statistical results suggested that the concentrations of peripheral CRP may be significantly increased for suicidal PDDs, both compared with non-suicidal PDDs and HCs, respectively. Homocysteine 167-170 C-reactive protein Homo sapiens 72-75 32680432-7 2020 Plasma CRP also showed a negative association with Hcys, and the ratio of saturated and polyunsaturated fatty acids intake showed a positive association with Hcys. Homocysteine 51-55 C-reactive protein Homo sapiens 7-10 32680432-8 2020 Regarding indirect effects, the results showed that the relationship between the presence of diabetes mellitus and Hcys is mediated by plasma CRP. Homocysteine 115-119 C-reactive protein Homo sapiens 142-145 32680432-10 2020 Novelty In end-stage renal disease, CRP influences plasma Hcys directly and also indirectly through its mediating effect. Homocysteine 58-62 C-reactive protein Homo sapiens 36-39 32963724-12 2020 Homocysteine and physical activity can predict the inflammation status induced by CRP. Homocysteine 0-12 C-reactive protein Homo sapiens 82-85 30047537-0 2018 A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction. Homocysteine 20-32 C-reactive protein Homo sapiens 48-66 30047537-1 2018 Aim To determine the relationship of homocysteine (HCY), uric acid (UA) and C-reactive protein (CRP) in serum of patients with acute myocardial infarction (AMI) prior to application of percutaneous coronary intervention (PCI) and their level of correlation in serum of patients with normal and elevated CRP (predictor of worse cardiovascular outcomes). Homocysteine 37-49 C-reactive protein Homo sapiens 76-94 30047537-1 2018 Aim To determine the relationship of homocysteine (HCY), uric acid (UA) and C-reactive protein (CRP) in serum of patients with acute myocardial infarction (AMI) prior to application of percutaneous coronary intervention (PCI) and their level of correlation in serum of patients with normal and elevated CRP (predictor of worse cardiovascular outcomes). Homocysteine 37-49 C-reactive protein Homo sapiens 96-99 28540883-3 2017 The aim of this study was to assess the association between homocysteine (Hcy) and highly sensitive CRP (hsCRP) in cardiovascular risk prediction in children with chronic kidney disease (CKD) on HD. Homocysteine 60-72 C-reactive protein Homo sapiens 100-103 28540883-3 2017 The aim of this study was to assess the association between homocysteine (Hcy) and highly sensitive CRP (hsCRP) in cardiovascular risk prediction in children with chronic kidney disease (CKD) on HD. Homocysteine 74-77 C-reactive protein Homo sapiens 100-103 27289003-6 2016 RESULTS: After adjustment for age, C-reactive protein, and creatinine, high homocysteine levels were associated with cardiovascular events [hazard ratio (HR) 1.23 per standard deviation (SD); 95% confidence interval (CI): 1.03-1.47], MI (HR 1.38 per SD; 95% CI: 1.03-1.85), and all-cause mortality (HR 1.41 per SD; 95% CI: 1.19-1.68). Homocysteine 76-88 C-reactive protein Homo sapiens 35-53 26367537-9 2015 Combining our results with recent studies, we propose that C4, CRP, and IgM in serum are significantly associated with HCY concentration. Homocysteine 119-122 C-reactive protein Homo sapiens 63-66 27760401-8 2016 Multivariable logistic regression analysis including age, sex, vascular risk factors, serum C-reactive protein, estimated glomerular filtration rate and homocysteine tertile disclosed that the highest serum homocysteine tertile was an independent predictor of advanced cerebral artery calcification (odds ratio = 1.45, confidence interval = 1.02-2.05) and advanced cerebral atherosclerosis (odds ratio = 1.42, confidence interval = 1.01-1.99) compared to the lowest group. Homocysteine 207-219 C-reactive protein Homo sapiens 92-110 26690891-11 2015 CONCLUSIONS: Results from this study suggested that Hcy concentration was increased in RA patients and associated with RA-related immunological-inflammatory and metabolic laboratory markers, including folate, vitamin B12, CRP, CysC, C3, C4. Homocysteine 52-55 C-reactive protein Homo sapiens 222-225 26371408-6 2015 In the whole group protein N-linked Hcy correlated only with C-reactive protein (CRP; r = 0.44, p < 0.0001). Homocysteine 36-39 C-reactive protein Homo sapiens 61-79 26371408-6 2015 In the whole group protein N-linked Hcy correlated only with C-reactive protein (CRP; r = 0.44, p < 0.0001). Homocysteine 36-39 C-reactive protein Homo sapiens 81-84 26371408-10 2015 Multiple regression adjusted for potential confounders showed that the only independent predictor of protein N-linked Hcy in the upper quartile was CRP > 3mg/L (odds ratio 3.04, 95% confidence interval 2.12-4.36, p < 0.0001). Homocysteine 118-121 C-reactive protein Homo sapiens 148-151 25941076-0 2016 Serum Levels of High-sensitivity C-Reactive Protein at Admission Are More Strongly Associated with Poststroke Depression in Acute Ischemic Stroke than Homocysteine Levels. Homocysteine 151-163 C-reactive protein Homo sapiens 33-51 24633270-8 2013 Logistic regression showed significant association between sub-clinical hypothyroidism, total plasma homocysteine and high-sensitivity C-reactive protein in the study group. Homocysteine 101-113 C-reactive protein Homo sapiens 135-153 19004529-6 2010 Only in the highest tertile of CRP, higher homocysteine was negatively associated with retention. Homocysteine 43-55 C-reactive protein Homo sapiens 31-34 23735372-1 2013 BACKGROUND: We investigated the relationship between C-reactive protein (CRP) and homocysteine on follow-up and subsequent mortality in young ischemic stroke patients in a population-based study. Homocysteine 82-94 C-reactive protein Homo sapiens 53-71 23735372-1 2013 BACKGROUND: We investigated the relationship between C-reactive protein (CRP) and homocysteine on follow-up and subsequent mortality in young ischemic stroke patients in a population-based study. Homocysteine 82-94 C-reactive protein Homo sapiens 73-76 23735372-12 2013 CONCLUSIONS: There is an independent association between CRP and homocysteine levels obtained several years after ischemic stroke in young adults and subsequent mortality, even when adjusting for traditional risk factors. Homocysteine 65-77 C-reactive protein Homo sapiens 57-60 23228159-8 2013 CONCLUSIONS: There is a complex association between CRP and homocysteine with specific subcomponents of MetS in patients with bipolar disorder and schizophrenia. Homocysteine 60-72 C-reactive protein Homo sapiens 52-55 22865000-8 2013 The higher CRP group was discriminated by the above variables in addition to lower VO(2max), serum metabolic syndrome components (triglycerides, glucose, and HDL cholesterol), higher insulin, homeostasis assessment of insulin resistance, uric acid, gamma-GT, and homocysteine. Homocysteine 263-275 C-reactive protein Homo sapiens 11-14 21640381-5 2011 In HepG2 cells, ER stress triggered by tunicamycin, thapsigargin and homocysteine markedly induced CRP expression and the activation of protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring transmembrane kinase/endonuclease 1alpha (IRE1alpha), activating transcription factor 6 (ATF6), and hepatocyte-specific cyclic AMP response element binding protein H (CREBH). Homocysteine 69-81 C-reactive protein Homo sapiens 99-102 21441154-9 2011 However, with consideration of CAB, CAB (>=2 segments with >=50% stenosis) remained the only independent predictor for the highest quartile of C-reactive protein (OR, 8.69; 95% CI, 2.41-31.30) and homocysteine (OR, 11.44; 95% CI, 2.61-50.11). Homocysteine 203-215 C-reactive protein Homo sapiens 149-167 21046182-5 2011 RESULTS: Plasma homocysteine levels were positively associated with microalbuminuria in men but not in women (p-interaction <0.0001) after adjusting for age, race/ethnicity, smoking, drinking, body mass index, physical activity, glomerular filtration rate, blood pressure, high-density lipoprotein cholesterol, glycated hemoglobin, serum folate, serum vitamin B(12), and C-reactive protein. Homocysteine 16-28 C-reactive protein Homo sapiens 374-392 19004529-8 2010 Both in the lower and middle tertile of CRP, higher homocysteine was associated with a faster rate of decline in information processing speed. Homocysteine 52-64 C-reactive protein Homo sapiens 40-43 20653803-0 2010 Relationship of serum homocysteine and high sensitivity C-reactive protein in elderly people with essential hypertension. Homocysteine 22-34 C-reactive protein Homo sapiens 56-74 18401567-0 2009 C-reactive protein gene polymorphisms affect plasma CRP and homocysteine concentrations in subjects with and without angiographically confirmed coronary artery disease. Homocysteine 60-72 C-reactive protein Homo sapiens 0-18 20078877-9 2010 CONCLUSION: The significant associations between certain gene variants with concentration variations in serum C-reactive protein and homocysteine among adult women need to be confirmed in further genetic association studies. Homocysteine 133-145 C-reactive protein Homo sapiens 110-128 19809863-3 2009 The aim of the study was to investigate serum Hcy concentration in patients with probable AD with age-matched controls and to determine whether there was an association between serum Hcy and C-reactive protein concentration in patients with probable AD. Homocysteine 183-186 C-reactive protein Homo sapiens 191-209 18401567-10 2009 There was no significant difference between CAD(+) and CAD(-) subjects in absolute frequencies for CRP -717A/G gene variant, but multivariate analysis showed that carriers of the rarer G allele had significantly higher CRP plasma concentrations in CAD(-) subjects (P = 0.031) and higher homocysteine concentrations in CAD(+) group (P < 0.001). Homocysteine 287-299 C-reactive protein Homo sapiens 219-222 19283524-3 2009 In this study, we investigated the relationship between plasma homocysteine levels and single nucleotide polymorphism (SNP) of the gene coding for methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in the biosynthesis of homocysteine, and the correlation between the plasma homocysteine levels and generally used inflammatory markers (C-reactive protein, erythrocyte sedimentation rate and matrix metalloproteinase-3) in 96 Japanese patients with RA. Homocysteine 63-75 C-reactive protein Homo sapiens 348-366 20157364-6 2008 RESULTS: Both human recombinant CRP and LPS significantly increased the production of IL-6 and MCP-1 in whole blood samples more than 4-fold (P < 0.001) but homocysteine did not. Homocysteine 160-172 C-reactive protein Homo sapiens 32-35