PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27339788-4	2016	Homocysteine significantly increased mRNA levels of CHOP and p53, resulting in the upregulation of their downstream target gene, p53 up-regulated modulator of apoptosis (PUMA).	Homocysteine	0-12	DNA damage inducible transcript 3	Homo sapiens	52-56	
11113529-6	2000	After 6 h treatment, gadd153, grp78 and grp94 mRNA levels increased markedly, but only when cells were exposed to levels of homocysteine high enough to induce cell injury.	Homocysteine	124-136	DNA damage inducible transcript 3	Homo sapiens	21-28	
27064126-5	2016	l-Serine inhibited homocysteine-induced ER stress as verified by decreased glucose-regulated protein 78kDa (GRP78) and C/EBP homologous protein (CHOP) expression as well as X-box binding protein 1 (xbp1) mRNA splicing.	Homocysteine	19-31	DNA damage inducible transcript 3	Homo sapiens	119-143	
27064126-5	2016	l-Serine inhibited homocysteine-induced ER stress as verified by decreased glucose-regulated protein 78kDa (GRP78) and C/EBP homologous protein (CHOP) expression as well as X-box binding protein 1 (xbp1) mRNA splicing.	Homocysteine	19-31	DNA damage inducible transcript 3	Homo sapiens	145-149	
17705221-7	2007	BHMT expression inhibited homocysteine-induced glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP) and homocysteine-induced cell death.	Homocysteine	26-38	DNA damage inducible transcript 3	Homo sapiens	88-112	
17705221-7	2007	BHMT expression inhibited homocysteine-induced glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP) and homocysteine-induced cell death.	Homocysteine	26-38	DNA damage inducible transcript 3	Homo sapiens	114-118	
10419887-5	1999	Consistent with its adverse effects on the ER, homocysteine alters the expression of genes sensitive to ER stress (ie, GADD45, GADD153, ATF-4, YY1).	Homocysteine	47-59	DNA damage inducible transcript 3	Homo sapiens	127-134	
10419887-6	1999	Several other genes observed to be differentially expressed by homocysteine are known to mediate cell growth and differentiation (ie, GADD45, GADD153, Id-1, cyclin D1, FRA-2), a finding that supports the observation that homocysteine causes a dose-dependent decrease in DNA synthesis in HUVEC.	Homocysteine	63-75	DNA damage inducible transcript 3	Homo sapiens	142-149	
9576870-3	1998	Here we show that homocysteine increases the expression of GRP78 and GADD153, stress-response genes induced by agents or conditions that adversely affect the function of the endoplasmic reticulum (ER).	Homocysteine	18-30	DNA damage inducible transcript 3	Homo sapiens	69-76	
32400851-0	2020	Homocysteine induces melanocytes apoptosis via PERK-eIF2alpha-CHOP pathway in vitiligo.	Homocysteine	0-12	DNA damage inducible transcript 3	Homo sapiens	62-66	
32400851-6	2020	Notably, Hcy induced cell apoptosis in melanocytes via activating reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress protein kinase RNA-like ER kinase (PERK)-eukaryotic translation initiation factor 2alpha (eIF2alpha)-C/EBP homologous protein (CHOP) pathway.	Homocysteine	9-12	DNA damage inducible transcript 3	Homo sapiens	261-265	
31585902-2	2020	Here, we tested whether blockage of homocysteine (Hcy) induced ERS and subsequent apoptosis in vascular smooth muscle cells can be inhibited by  blockage of PERK/eIF2alpha/ATF4/CHOP signaling.	Homocysteine	36-48	DNA damage inducible transcript 3	Homo sapiens	177-181	
31585902-2	2020	Here, we tested whether blockage of homocysteine (Hcy) induced ERS and subsequent apoptosis in vascular smooth muscle cells can be inhibited by  blockage of PERK/eIF2alpha/ATF4/CHOP signaling.	Homocysteine	50-53	DNA damage inducible transcript 3	Homo sapiens	177-181	
31585902-4	2020	Long-term Hcy exposure, however, increased the expression of ATF-4 and CHOP and led to apoptosis.	Homocysteine	10-13	DNA damage inducible transcript 3	Homo sapiens	71-75	
27995330-5	2017	Hcy increased annexin V-positive cells, DHE oxidation, GRP78 and CHOP expression and Xbp-1 mRNA splicing, indicating that Hcy induces apoptosis, oxidative stress and ER stress.	Homocysteine	0-3	DNA damage inducible transcript 3	Homo sapiens	65-69	
27809414-8	2017	The underlying mechanisms involve the inhibition of Hcy-induced activation of binding protein (Bip) and C/EBP homologous protein (CHOP), as well as the phosphorylation of protein kinase RNA-like ER kinase (PERK) or inositol-requiring enzyme 1 alpha (IRE1alpha).	Homocysteine	52-55	DNA damage inducible transcript 3	Homo sapiens	104-128	
27809414-8	2017	The underlying mechanisms involve the inhibition of Hcy-induced activation of binding protein (Bip) and C/EBP homologous protein (CHOP), as well as the phosphorylation of protein kinase RNA-like ER kinase (PERK) or inositol-requiring enzyme 1 alpha (IRE1alpha).	Homocysteine	52-55	DNA damage inducible transcript 3	Homo sapiens	130-134