PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25547897-0	2015	Transglutaminase 2 is involved in homocysteine-induced activation of human THP-1 monocytes.	Homocysteine	34-46	GLI family zinc finger 2	Homo sapiens	75-80	
27221153-0	2016	FABP4-mediated homocysteine-induced cholesterol accumulation in THP-1 monocyte-derived macrophages and the potential epigenetic mechanism.	Homocysteine	15-27	GLI family zinc finger 2	Homo sapiens	64-69	
18602108-6	2009	Homocysteine also stimulated monocytic THP1 cells to promote aortic smooth muscle cell calcification as evidenced by significant higher calcium deposition and alkaline phosphatase activity compared to incubation without homocysteine (p<or=0.05).	Homocysteine	0-12	GLI family zinc finger 2	Homo sapiens	39-43	
16484557-4	2006	Incubation of THP-1 cells with Hcy (200 micromol/L) for 72 h in the presence of phorbol 12-myristate 13-acetate (PMA) (10 nmol/L) caused a 37.8+/-5.2% increase in CD36 expression compared with PMA-stimulated cells without Hcy (P<0.01).	Homocysteine	31-34	GLI family zinc finger 2	Homo sapiens	14-19	
16484557-4	2006	Incubation of THP-1 cells with Hcy (200 micromol/L) for 72 h in the presence of phorbol 12-myristate 13-acetate (PMA) (10 nmol/L) caused a 37.8+/-5.2% increase in CD36 expression compared with PMA-stimulated cells without Hcy (P<0.01).	Homocysteine	222-225	GLI family zinc finger 2	Homo sapiens	14-19	
16626305-8	2006	Hcy treatment (20-100 microM) caused an activation of NADPH oxidase and an increase in the superoxide anion level in monocytes (THP-1, a human monocytic cell line).	Homocysteine	0-3	GLI family zinc finger 2	Homo sapiens	128-133	
11356643-0	2001	Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-kappaB in THP-1 macrophages.	Homocysteine	0-12	GLI family zinc finger 2	Homo sapiens	94-99	
15842806-1	2005	OBJECTIVE: To investigate the effect of homocysteine (HCY) on activation of nuclear factor (NF-kappaB) and inhibitory factor IkappaB-alpha in human monocyte cell line THP-1, as well as its association with macrophage inflammatory protein (MIP-1alpha) upregulation.	Homocysteine	54-57	GLI family zinc finger 2	Homo sapiens	167-172	
15842806-5	2005	RESULTS: Compared with controls, HCY, at a concentration of 0.1 mmol/L, was able to enhance the expression of MIP-1alpha mRNA (up to 3.69-fold) and protein (1.16-fold) in THP-1 monocytes, as well as enhance NF-kappaB P65 transcription to nuclear proteins.	Homocysteine	33-36	GLI family zinc finger 2	Homo sapiens	171-176	
15842806-7	2005	Moreover, the level of IkappaB-alpha protein in THP-1 monocytes decreased after a 30-minute incubation with HCY, which gradually increased after 120 minutes.	Homocysteine	108-111	GLI family zinc finger 2	Homo sapiens	48-53	
15842806-8	2005	CONCLUSIONS: Homocysteine at a pathologic concentration stimulates MIP-1alpha expression in THP-1 monocytes, probably via NF-kappaB activation.	Homocysteine	13-25	GLI family zinc finger 2	Homo sapiens	92-97	
12957716-0	2003	Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages.	Homocysteine	0-12	GLI family zinc finger 2	Homo sapiens	85-90	
11415454-4	2001	The objective of the present study was to investigate the effect of homocysteine on CCR2 expression in human THP-1 monocytes.	Homocysteine	68-80	GLI family zinc finger 2	Homo sapiens	109-114	
15842806-0	2005	[Homocysteine induces macrophage inflammatory protein-1alpha expression by activating NF-kappaB in THP-1 monocytes].	Homocysteine	1-13	GLI family zinc finger 2	Homo sapiens	99-104	
12957716-5	2003	We investigated VEGF mRNA expression and VEGF secretion by homocysteine (Hcy) in differentiated THP-1 macrophages.	Homocysteine	73-76	GLI family zinc finger 2	Homo sapiens	96-101	
11356643-9	2001	In conclusion, our results demonstrate that homocysteine, at pathological concentration, stimulates MCP-1 expression in THP-1 macrophages via NF-kappaB activation.	Homocysteine	44-56	GLI family zinc finger 2	Homo sapiens	120-125	
31338841-7	2020	Homocysteine (Hcy) decreased H 2 S expression while promoting the synthesis of IL-1beta and TNF-alpha in THP-1 and raw264.7 cells.	Homocysteine	14-17	GLI family zinc finger 2	Homo sapiens	105-110