PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12701066-1 2003 The purpose of this study was to test whether transient increases in homocysteine would promote changes in markers of endothelial injury, cellular fibronectin (cFN), and soluble vascular cell adhesion molecule 1 (sVCAM-1). Homocysteine 69-81 vascular cell adhesion molecule 1 Homo sapiens 178-211 15784037-11 2005 Treatment of HIMEC with homocysteine, and synergistically with the combination of TNF-alpha and homocysteine, triggered HIMEC inflammation, resulting in VCAM-1 up-regulation, MCP-1 production, and p38 phosphorylation. Homocysteine 24-36 vascular cell adhesion molecule 1 Homo sapiens 153-159 15784037-11 2005 Treatment of HIMEC with homocysteine, and synergistically with the combination of TNF-alpha and homocysteine, triggered HIMEC inflammation, resulting in VCAM-1 up-regulation, MCP-1 production, and p38 phosphorylation. Homocysteine 96-108 vascular cell adhesion molecule 1 Homo sapiens 153-159 11950695-0 2002 Homocysteine upregulates vascular cell adhesion molecule-1 expression in cultured human aortic endothelial cells and enhances monocyte adhesion. Homocysteine 0-12 vascular cell adhesion molecule 1 Homo sapiens 25-58 11888519-5 2002 We also demonstrated that HCY increases endothelial surface expression and mRNA level of adhesion molecules, VCAM-1 and E-selectin. Homocysteine 26-29 vascular cell adhesion molecule 1 Homo sapiens 109-115 11950695-6 2002 In support of our hypothesis, vascular cell adhesion molecule (VCAM)-1 mRNA expression increased 5-fold in HAECs after 3 hours of treatment with 100 micromol/L homocysteine, as assessed by quantitative reverse transcription- polymerase chain reaction. Homocysteine 160-172 vascular cell adhesion molecule 1 Homo sapiens 30-70 11950695-7 2002 Neutralizing antibody studies confirmed the involvement of VCAM-1 in mediating monocyte adhesion to homocysteine-stimulated HAECs. Homocysteine 100-112 vascular cell adhesion molecule 1 Homo sapiens 59-65 11162639-3 2001 Incubation of endothelial cells with homocysteine resulted in dose-dependent reduction in TNF-alpha-induced (5 ng/ml) expression of VCAM-1, E-selectin, and ICAM-1 (the latter less pronounced). Homocysteine 37-49 vascular cell adhesion molecule 1 Homo sapiens 132-138 11570657-5 2001 sE-selectin levels were correlated with the extent of coronary atherosclerosis (r = 0.444, p < 0.05), and plasma homocysteine levels were associated with vascular cell adhesion molecule-1 (r = 0.479, p < 0.05) in unstable cases. Homocysteine 116-128 vascular cell adhesion molecule 1 Homo sapiens 157-190 10998075-0 2000 Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C-reactive protein in type 2 diabetic and non-diabetic subjects - The Hoorn Study. Homocysteine 6-18 vascular cell adhesion molecule 1 Homo sapiens 79-112 18406566-0 2008 Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells. Homocysteine 18-30 vascular cell adhesion molecule 1 Homo sapiens 44-77 8916961-8 1996 These results indicate that alpha 4 beta 1/VCAM-1 is central to the interaction between HCs and endothelium/accessory cells. Homocysteine 88-91 vascular cell adhesion molecule 1 Homo sapiens 43-49 27190988-9 2016 We found that Hcy could induce cell apoptosis with corresponding decrease of nitric oxide (NO) level, increase of endothelin-1 (ET-1), intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) levels, elevation of ROS, and dissipation of MMP. Homocysteine 14-17 vascular cell adhesion molecule 1 Homo sapiens 179-216 27190988-9 2016 We found that Hcy could induce cell apoptosis with corresponding decrease of nitric oxide (NO) level, increase of endothelin-1 (ET-1), intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) levels, elevation of ROS, and dissipation of MMP. Homocysteine 14-17 vascular cell adhesion molecule 1 Homo sapiens 218-224 26276934-4 2015 These factors, together with the increased levels of homocysteine observed in BD patients, induce the endothelial cell expression of adhesion molecules (VCAM-1 and ICAM-1) and tissue factor; the release of cytokines, soluble CD40L (sCD40L), matrix metalloproteinase-9, and blood coagulation factor V; the inhibition of fibrinolysis; the disruption of nitric oxide metabolism; and the increase in platelet reactivity and lipid peroxidation. Homocysteine 53-65 vascular cell adhesion molecule 1 Homo sapiens 153-159 17906965-3 2008 We investigated the effects of Cholestin extract on the expression of vascular cell adhesion molecule-1 (VCAM-1) by homocysteine (HCY)-treated human aortic endothelial cells (HAECs). Homocysteine 116-128 vascular cell adhesion molecule 1 Homo sapiens 70-103 17906965-3 2008 We investigated the effects of Cholestin extract on the expression of vascular cell adhesion molecule-1 (VCAM-1) by homocysteine (HCY)-treated human aortic endothelial cells (HAECs). Homocysteine 116-128 vascular cell adhesion molecule 1 Homo sapiens 105-111 17906965-3 2008 We investigated the effects of Cholestin extract on the expression of vascular cell adhesion molecule-1 (VCAM-1) by homocysteine (HCY)-treated human aortic endothelial cells (HAECs). Homocysteine 130-133 vascular cell adhesion molecule 1 Homo sapiens 70-103 17906965-3 2008 We investigated the effects of Cholestin extract on the expression of vascular cell adhesion molecule-1 (VCAM-1) by homocysteine (HCY)-treated human aortic endothelial cells (HAECs). Homocysteine 130-133 vascular cell adhesion molecule 1 Homo sapiens 105-111 17906965-5 2008 Quantitative PCR and immunoblot analysis showed that Cholestin extract significantly attenuated HCY-induced expression of VCAM-1 mRNA and protein, respectively. Homocysteine 96-99 vascular cell adhesion molecule 1 Homo sapiens 122-128 18226044-11 2008 HCY stimulated endothelial VCAM-1 but not ICAM-1 expression in a dose-dependent manner. Homocysteine 0-3 vascular cell adhesion molecule 1 Homo sapiens 27-33 18226044-12 2008 Monoclonal antibodies to VCAM-1 attenuated HCY-induced endothelial adhesiveness. Homocysteine 43-46 vascular cell adhesion molecule 1 Homo sapiens 25-31 18226044-13 2008 Simvastatin or pravastatin significantly reduced HCY-induced VCAM-1 expression and endothelial adhesiveness to MNCs from CAD patients. Homocysteine 49-52 vascular cell adhesion molecule 1 Homo sapiens 61-67 18226044-15 2008 Statins could directly reduce HCY-induced endothelial-MNC adhesion via VCAM-1 inhibition, suggesting its potential implication in HCY-related atherosclerosis disease. Homocysteine 30-33 vascular cell adhesion molecule 1 Homo sapiens 71-77 17586618-0 2007 Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants. Homocysteine 0-12 vascular cell adhesion molecule 1 Homo sapiens 21-27 17586618-2 2007 Because VCAM-1 expression is crucial in monocyte adhesion and early atherogenesis, we evaluated the NF-kappaB-related induction of VCAM-1 by homocysteine (Hcy) and the possible inhibitory effect of dietary polyphenolic antioxidants, such as trans-resveratrol (RSV) and hydroxytyrosol (HT), which are known inhibitors of NF-kappaB-mediated VCAM-1 induction. Homocysteine 141-153 vascular cell adhesion molecule 1 Homo sapiens 131-137 17586618-2 2007 Because VCAM-1 expression is crucial in monocyte adhesion and early atherogenesis, we evaluated the NF-kappaB-related induction of VCAM-1 by homocysteine (Hcy) and the possible inhibitory effect of dietary polyphenolic antioxidants, such as trans-resveratrol (RSV) and hydroxytyrosol (HT), which are known inhibitors of NF-kappaB-mediated VCAM-1 induction. Homocysteine 141-153 vascular cell adhesion molecule 1 Homo sapiens 131-137 17586618-7 2007 NF-kappaB inhibitors decreased Hcy-induced intracellular reactive oxygen species and VCAM-1 expression. Homocysteine 31-34 vascular cell adhesion molecule 1 Homo sapiens 85-91