PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21945668-5 2011 In the present study, we found that LMP1 inhibits the expression of NAPA, an endoplasmic reticulum SNARE protein that possesses anti-apoptotic properties against the DNA-damaging drug cisplatin. Acecainide 68-72 PDZ and LIM domain 7 Homo sapiens 36-40 21945668-8 2011 Similarly, overexpression of NAPA reduced the effect of LMP1 and induced resistance to cisplatin. Acecainide 29-33 PDZ and LIM domain 7 Homo sapiens 56-60 21945668-10 2011 These findings suggest that the viral protein LMP1 may sensitize cancer cells to cisplatin chemotherapy by downregulating NAPA and by enhancing the formation of p50 homodimers which in turn inhibit the expression of NF-kappaB regulated anti-apoptotic genes. Acecainide 122-126 PDZ and LIM domain 7 Homo sapiens 46-50