PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27836674-2 2017 The ability of N-acetyl phenylalanine derivative (NAPA) to increase cartilage matrix components and to reduce inflammatory cytokines, inhibiting IKKalpha kinase activity, has been observed in vitro. Acecainide 50-54 conserved helix-loop-helix ubiquitous kinase Mus musculus 145-153 27836674-6 2017 RESULTS: The injection of NAPA significantly improved cartilage thickness (CT) and reduced Chambers and Mankin modified scores and fibrillation index (FI), with weaker MMP13, ADAMTS5, MMP10 and IKKalpha staining. Acecainide 26-30 conserved helix-loop-helix ubiquitous kinase Mus musculus 194-202 27836674-8 2017 CONCLUSIONS: NAPA markedly improved the physical structure of articular cartilage while reducing catabolic enzymes, extracellular matrix (ECM) remodeling and IKKalpha expression, showing to be able to exert a chondroprotective activity in vivo. Acecainide 13-17 conserved helix-loop-helix ubiquitous kinase Mus musculus 158-166