PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9389730-5 1997 Inhibition of LPS-mediated activation of NF-kbeta by lovastatin, NaPA, and FPT inhibitor II in astrocytes indicates that the observed inhibition of iNOS expression is mediated via inhibition of NF-kbeta activation. Acecainide 65-69 nitric oxide synthase 2 Rattus norvegicus 148-152 9389730-2 1997 Lovastatin and sodium phenylacetate (NaPA) were found to inhibit LPS- and cytokine-mediated production of NO and expression of iNOS in rat primary astrocytes; this inhibition was not due to depletion of end products of mevalonate pathway (e.g., cholesterol and ubiquinone). Acecainide 37-41 nitric oxide synthase 2 Rattus norvegicus 127-131 9389730-3 1997 Reversal of the inhibitory effect of lovastatin on LPS-induced iNOS expression by mevalonate and farnesyl pyrophosphate and reversal of the inhibitory effect of NaPA on LPS-induced iNOS expression by farnesyl pyrophosphate, however, suggests a role of farnesylation in the LPS-mediated induction of iNOS. Acecainide 161-165 nitric oxide synthase 2 Rattus norvegicus 181-185 9389730-3 1997 Reversal of the inhibitory effect of lovastatin on LPS-induced iNOS expression by mevalonate and farnesyl pyrophosphate and reversal of the inhibitory effect of NaPA on LPS-induced iNOS expression by farnesyl pyrophosphate, however, suggests a role of farnesylation in the LPS-mediated induction of iNOS. Acecainide 161-165 nitric oxide synthase 2 Rattus norvegicus 181-185