PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10438960-3	1999	The effects of CTS are mediated by down-regulation of IL-1beta-dependent inducible NO production, and are directly attributed to the inhibition of inducible NO synthase (iNOS) mRNA expression and protein synthesis.	castanospermine	15-18	nitric oxide synthase 2	Homo sapiens	147-168	
10438960-3	1999	The effects of CTS are mediated by down-regulation of IL-1beta-dependent inducible NO production, and are directly attributed to the inhibition of inducible NO synthase (iNOS) mRNA expression and protein synthesis.	castanospermine	15-18	nitric oxide synthase 2	Homo sapiens	170-174	
10438960-4	1999	The inhibition of iNOS induction by CTS is paralleled by abrogation of IL-1beta-induced down-regulation of proteoglycan synthesis.	castanospermine	36-39	nitric oxide synthase 2	Homo sapiens	18-22	
10438960-5	1999	Furthermore, CTS inhibits iNOS expression and up-regulates proteoglycan synthesis at concentrations of IL-1beta frequently observed in inflamed arthritic joints, suggesting that the actions of CTS may be clinically relevant in suppressing the sustained effects of pathological levels of IL-1beta in vivo.	castanospermine	13-16	nitric oxide synthase 2	Homo sapiens	26-30	
11263775-8	2001	Concomitant application of CTS abrogated the catabolic effects of IL-1beta on TMJ chondrocytes by inhibiting iNOS, COX-2, and MMP-1 mRNA production and NO, PGE2, and MMP-1 synthesis.	castanospermine	27-30	nitric oxide synthase 2	Homo sapiens	109-113