PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6409435-1	1983	Inhalation of toluene vapour of 2000 ppm increased the activities of aniline hydroxylase, aminopyrine N-demethylase, aryl hydrocarbon hydroxylase and NADPH-cytochrome c reductase and the concentrations of cytochromes P-450 and b5 in liver microsomes of adult male rats after an exposure period of 1 day or less.	Toluene	14-21	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	117-145	
4060169-2	1985	Exposure to 80 ppm toluene decreased the liver microsomal AHH activity and the rate of 7 alpha- and 6 beta-hydroxylation of androstenedione in 8-day-old-pups.	Toluene	19-26	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	58-61	
4060169-3	1985	On the other hand, neonatal exposure to 500 or 1000 ppm toluene resulted in a significant increase in AHH and 7-ethoxyresorufin O-deethylase activities and in the formation of 16-oxygenated metabolites of androstenedione in 8-day-old animals.	Toluene	56-63	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	102-105	
4060169-6	1985	In 56-day-old male rats, however, neonatal exposure to 80 ppm toluene resulted in a decreased rate of 6 beta-hydroxylation of androstenedione and a reduced AHH activity.	Toluene	62-69	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	156-159	
8996725-2	1996	The addition of acetone potentiated the induction of CYP1A1/2 to 4 minutes ethoxyresorufin deethylation that from control animals after pretreatment with toluene.	Toluene	154-161	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	53-59	
9726784-3	1998	Exposure to 375 ppm toluene, 6 h/d for up to 5 d, resulted in significant inhibition of the activity of pulmonary arylhydrocarbon hydroxylase (AHH), cytochrome P-4502B1 (CYP2B1), and CYP4B1, but not CYP1A1.	Toluene	20-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	143-146	
9726784-3	1998	Exposure to 375 ppm toluene, 6 h/d for up to 5 d, resulted in significant inhibition of the activity of pulmonary arylhydrocarbon hydroxylase (AHH), cytochrome P-4502B1 (CYP2B1), and CYP4B1, but not CYP1A1.	Toluene	20-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	199-205	
9726784-4	1998	After exposure to lower toluene levels (125 ppm, 6 h/d, 3 d), the activities of lung AHH, CYP2B1, and CYP4B1 were also significantly decreased, but in a dose-related manner.	Toluene	24-31	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	85-88	
9726784-8	1998	Toluene was found to be a more potent inhibitor of lung CYP2B1 and CYP1A1 (IC50, 10(-4) M) than benzaldehyde, but neither toluene nor benzyl alcohol was an effective inhibitor of lung CYP4B1.	Toluene	0-7	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	67-73	
9726784-9	1998	Toluene and its metabolites were weaker inhibitors of CYP1A1 than of CYP2B1.	Toluene	0-7	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	54-60	
9726784-10	1998	For CYP2B1 and CYP1A1, the order of inhibitory potency was toluene > benzaldehyde > benzyl alcohol and suggests that both the parent molecule and its metabolites may act in concert to inhibit catalytic activity of these cytochromes.	Toluene	59-66	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	15-21	
7890112-2	1994	Toluene exposure induces CYP1A1/2, CYP2B1/2, CYP2E1 and CYP3A1, but decreases CYP2C11/6 and CYP2A1 in adult males.	Toluene	0-7	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-31