PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10747881-5 2000 Here we show that exposure of human recombinant alpha-synuclein to nitrating agents (peroxynitrite/CO(2) or myeloperoxidase/H(2)O(2)/nitrite) induces formation of nitrated alpha-synuclein oligomers that are highly stabilized due to covalent cross-linking via the oxidation of tyrosine to form o,o"-dityrosine. dityrosine 293-308 myeloperoxidase Homo sapiens 108-123 31238865-10 2019 MPO-dependent oxidation of free tyrosine results in the formation of tyrosyl radicals, that do not oxidize aromatic amino acid residues in proteins because of the high rate of recombination with dityrosine formation. dityrosine 195-205 myeloperoxidase Homo sapiens 0-3 18620432-5 2008 Quercetin and the plasma metabolites inhibited the formation of dityrosine catalyzed by the MPO enzyme and HL-60 cells in a dose-dependent manner. dityrosine 64-74 myeloperoxidase Homo sapiens 92-95 12834295-2 2003 The formation of dityrosine from the MPO/H2O2/L-tyrosine system was used as an indicator of the MPO activity. dityrosine 17-27 myeloperoxidase Homo sapiens 37-40 12834295-2 2003 The formation of dityrosine from the MPO/H2O2/L-tyrosine system was used as an indicator of the MPO activity. dityrosine 17-27 myeloperoxidase Homo sapiens 96-99 12126792-0 2002 Tyrosyl radical production by myeloperoxidase: a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins. dityrosine 94-104 myeloperoxidase Homo sapiens 30-45 12126792-4 2002 Protein-bound tyrosyl residues exposed to myeloperoxidase, H(2)O(2), and L-tyrosine were also oxidized to o,o"-dityrosine. dityrosine 106-121 myeloperoxidase Homo sapiens 42-57 22112843-7 2012 MPO-induced oxidation of tyrosine is relevant to what can be in vivo; we detected MPO-catalyzed formation of dityrosine in the presence of plasma under experimental conditions when tyrosine concentration was about three magnitudes of order less than the Cl(-) concentration. dityrosine 109-119 myeloperoxidase Homo sapiens 0-3 22112843-7 2012 MPO-induced oxidation of tyrosine is relevant to what can be in vivo; we detected MPO-catalyzed formation of dityrosine in the presence of plasma under experimental conditions when tyrosine concentration was about three magnitudes of order less than the Cl(-) concentration. dityrosine 109-119 myeloperoxidase Homo sapiens 82-85 18620432-4 2008 Immunohistochemical staining showed that a quercetin metabolite was colocalized with macrophages, MPO, and dityrosine, an MPO-derived oxidation product of tyrosine, in human atherosclerotic aorta. dityrosine 107-117 myeloperoxidase Homo sapiens 122-125 8981031-5 1997 When human albumin was exposed to the MPO-H2O2 system, BT was detected after hydrolysis of the protein in the mixture. dityrosine 55-57 myeloperoxidase Homo sapiens 38-41 8981031-6 1997 Judging from the chemiluminescence spectra of activated PMNs and the MPO-catalyzed tyrosine oxidation, at least two excited species in triplet states-one for tyrosine and another for BT-would be generated in these systems. dityrosine 183-185 myeloperoxidase Homo sapiens 69-72 8702710-0 1996 Human phagocytes employ the myeloperoxidase-hydrogen peroxide system to synthesize dityrosine, trityrosine, pulcherosine, and isodityrosine by a tyrosyl radical-dependent pathway. dityrosine 83-93 myeloperoxidase Homo sapiens 28-43 8702710-2 1996 Active myeloperoxidase is a component of human atherosclerotic lesions, and atherosclerotic tissue exhibits selective enrichment of protein dityrosine cross-links, a well characterized product of myeloperoxidase. dityrosine 140-150 myeloperoxidase Homo sapiens 7-22 8702710-2 1996 Active myeloperoxidase is a component of human atherosclerotic lesions, and atherosclerotic tissue exhibits selective enrichment of protein dityrosine cross-links, a well characterized product of myeloperoxidase. dityrosine 140-150 myeloperoxidase Homo sapiens 196-211 8382689-0 1993 Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages. dityrosine 0-10 myeloperoxidase Homo sapiens 66-81 8390491-3 1993 Protein-bound tyrosyl residues exposed to myeloperoxidase, H2O2, and L-tyrosine were oxidized to o,o"-dityrosine, a stable product of the tyrosyl radical. dityrosine 97-112 myeloperoxidase Homo sapiens 42-57 8390491-8 1993 The requirement for free L-tyrosine and H2O2 for dityrosine formation and the inhibition by heme poisons support the hypothesis that myeloperoxidase catalyzes the cross-linking of proteins by a peroxidative mechanism involving tyrosyl radical. dityrosine 49-59 myeloperoxidase Homo sapiens 133-148 8390491-10 1993 We speculate that protein dityrosine cross-linking by myeloperoxidase may play a role in bacterial killing or injuring normal tissue. dityrosine 26-36 myeloperoxidase Homo sapiens 54-69 8390491-11 1993 The intense fluorescence and stability of biphenolic compounds may allow dityrosine to act as a marker for proteins oxidatively damaged by myeloperoxidase in phagocyte-rich inflammatory lesions. dityrosine 73-83 myeloperoxidase Homo sapiens 139-154 8341680-9 1993 We have recently found that myeloperoxidase, a heme protein secreted by activated phagocytes, can also convert L-tyrosine to o,o"-dityrosine. dityrosine 125-140 myeloperoxidase Homo sapiens 28-43 8382689-3 1993 Dityrosine synthesis by the myeloperoxidase-H2O2 system did not require halide and was partially inhibited by Cl-. dityrosine 0-10 myeloperoxidase Homo sapiens 28-43 8382689-4 1993 At physiological concentrations of Cl-, L-tyrosine, and other plasma amino acids, purified myeloperoxidase utilized 26% of the H2O2 in the reaction mixture to form dityrosine. dityrosine 164-174 myeloperoxidase Homo sapiens 91-106 1846732-4 1991 When 1.14 microM fibronectin was exposed to 50-400 microM HOCl or 50-400 microM H2O2 plus myeloperoxidase and Cl-, there was progressive loss of tryptophan fluorescence and cysteines, and an increase in bityrosine fluorescence and carbonyl content. dityrosine 203-213 myeloperoxidase Homo sapiens 90-105