PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34884761-8 2021 Moreover, using GMC101 mutant worms that express the full-length human amyloid beta, we found that vitamin B12 deficiency did not affect the gene and protein expressions of amyloid beta but increased the formation of dityrosine crosslinking in the amyloid beta protein. dityrosine 217-227 amyloid beta precursor protein Homo sapiens 71-83 34884761-8 2021 Moreover, using GMC101 mutant worms that express the full-length human amyloid beta, we found that vitamin B12 deficiency did not affect the gene and protein expressions of amyloid beta but increased the formation of dityrosine crosslinking in the amyloid beta protein. dityrosine 217-227 amyloid beta precursor protein Homo sapiens 248-260 34884761-10 2021 In GMC101 mutant worms, vitamin B12 deficiency-induced oxidative stress triggers dityrosine-crosslinked amyloid beta formation, which might promote its stabilization and toxic oligomerization. dityrosine 81-91 amyloid beta precursor protein Homo sapiens 104-116 34519476-3 2021 Amyloid-beta (Abeta) peptides which aggregate and accumulate in the plaques of Alzheimer"s disease (AD) have sequential N-terminal truncations and multiple post-translational modifications (PTM) such as isomerization, pyroglutamate formation, phosphorylation, nitration, and dityrosine cross-linking. dityrosine 275-285 amyloid beta precursor protein Homo sapiens 0-12 34519476-3 2021 Amyloid-beta (Abeta) peptides which aggregate and accumulate in the plaques of Alzheimer"s disease (AD) have sequential N-terminal truncations and multiple post-translational modifications (PTM) such as isomerization, pyroglutamate formation, phosphorylation, nitration, and dityrosine cross-linking. dityrosine 275-285 amyloid beta precursor protein Homo sapiens 14-19 30385800-0 2018 Copper Redox Cycling Inhibits Abeta Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Abeta Dimer. dityrosine 105-115 amyloid beta precursor protein Homo sapiens 116-121 30385800-4 2018 Using fluorescence measurements and UV absorbance, we show that dityrosine can be formed aerobically when Abeta is incubated with Cu2+ and hydrogen-peroxide, or in a Cu2+ and ascorbate redox mixture. dityrosine 64-74 amyloid beta precursor protein Homo sapiens 106-111 30385800-5 2018 The dityrosine cross-linking can occur for both monomeric and fibrillar forms of Abeta. dityrosine 4-14 amyloid beta precursor protein Homo sapiens 81-86 29537826-7 2018 Third, we applied these MS methods to the analysis of brain Abeta dimer samples allowing the detection of the CL [Abeta(6-16)]2 peptide comprising a dityrosine cross-link. dityrosine 149-159 amyloid beta precursor protein Homo sapiens 60-65 29537826-7 2018 Third, we applied these MS methods to the analysis of brain Abeta dimer samples allowing the detection of the CL [Abeta(6-16)]2 peptide comprising a dityrosine cross-link. dityrosine 149-159 amyloid beta precursor protein Homo sapiens 114-119 29332049-8 2018 Also by studying Y10 as an endogenous peroxidase substrate for Abeta-heme complexes, ratio-specific effects were observed, showing an optimal dityrosine formation at an about 40-fold peptide excess. dityrosine 142-152 amyloid beta precursor protein Homo sapiens 63-68 24785004-2 2014 In the absence of sufficient brain-derived dimers, we studied one of the only possible dimers that could be produced in vivo, [Abeta](DiY) (dityrosine cross-linked Abeta). dityrosine 140-150 amyloid beta precursor protein Homo sapiens 127-132 17297919-10 2007 Importantly, the formation of dityrosine crosslinked Abeta, by the oxidative modification of the peptide, only occurs at equimolar molar ratios and above. dityrosine 30-40 amyloid beta precursor protein Homo sapiens 53-58 24351276-0 2013 A central role for dityrosine crosslinking of Amyloid-beta in Alzheimer"s disease. dityrosine 19-29 amyloid beta precursor protein Homo sapiens 46-58 24351276-4 2013 RESULTS: We have investigated the formation of dityrosine cross-links in Abeta42 formed by covalent ortho-ortho coupling of two tyrosine residues under conditions of oxidative stress with elevated copper and shown that dityrosine can be formed in vitro in Abeta oligomers and fibrils and that these links further stabilize the fibrils. dityrosine 47-57 amyloid beta precursor protein Homo sapiens 73-78 24351276-4 2013 RESULTS: We have investigated the formation of dityrosine cross-links in Abeta42 formed by covalent ortho-ortho coupling of two tyrosine residues under conditions of oxidative stress with elevated copper and shown that dityrosine can be formed in vitro in Abeta oligomers and fibrils and that these links further stabilize the fibrils. dityrosine 219-229 amyloid beta precursor protein Homo sapiens 73-78 24351276-5 2013 Dityrosine crosslinking was present in internalized Abeta in cell cultures treated with oligomeric Abeta42 using a specific antibody for dityrosine by immunogold labeling transmission electron microscopy. dityrosine 0-10 amyloid beta precursor protein Homo sapiens 52-57 24351276-5 2013 Dityrosine crosslinking was present in internalized Abeta in cell cultures treated with oligomeric Abeta42 using a specific antibody for dityrosine by immunogold labeling transmission electron microscopy. dityrosine 137-147 amyloid beta precursor protein Homo sapiens 52-57 24351276-7 2013 CONCLUSIONS: Abeta dimers may be stabilized by dityrosine crosslinking. dityrosine 47-57 amyloid beta precursor protein Homo sapiens 13-18 22528079-3 2012 Here we report a simple and reproducible method for the production of radically derived dityrosine cross-linked oligomers of Abeta, through reaction with copper and ascorbic acid. dityrosine 88-98 amyloid beta precursor protein Homo sapiens 125-130 18599641-8 2008 The structure of the high-affinity Cu(2+) binding site is consistent with the hypothesis that the redox activity of the metal ion bound to Abeta can lead to the formation of dityrosine-linked dimers found in AD. dityrosine 174-184 amyloid beta precursor protein Homo sapiens 139-144 16271394-5 2005 DFT also predicted that Abeta will cross-link via covalent dityrosine formation during the oxidation of ascorbate but not during the oxidation of cholesterol. dityrosine 59-69 amyloid beta precursor protein Homo sapiens 24-29 14717612-0 2004 Copper mediates dityrosine cross-linking of Alzheimer"s amyloid-beta. dityrosine 16-26 amyloid beta precursor protein Homo sapiens 56-68 10211406-5 1999 Further experiments performed by reverse-phase high performance liquid chromatography (RP-HPLC), and monitored by fluorescence detection, showed that the dimeric A beta (1-42) forms induced by the peroxidase reaction are the outcomes of dityrosine bridge formation. dityrosine 237-247 amyloid beta precursor protein Homo sapiens 162-168