PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11254702-7 2001 These findings, in conjunction with the known immunomodulatory capacities of PGs, suggest that COX-2 expression by the small intestine lamina propria is a basal state contributing to the hyporesponsiveness of the intestinal immune response. Phosphatidylglycerols 77-80 cytochrome c oxidase II, mitochondrial Mus musculus 95-100 24378735-7 2014 These results indicate that CREB-dependent expression of COX-2 for the production of anti-adipogenic PGs is critical for the regulation of the early phase of adipogenesis. Phosphatidylglycerols 101-104 cytochrome c oxidase II, mitochondrial Mus musculus 57-62 21668646-7 2011 An FP receptor antagonist and each inhibitor for MEK and COX-2 suppressed the PGF(2alpha) -derived induction of synthesis of these PGs. Phosphatidylglycerols 131-134 cytochrome c oxidase II, mitochondrial Mus musculus 57-62 19749081-15 2009 Furthermore, for the first time, we demonstrated that the production of PGs depended in part on COX-2 in endocardial endothelium through the muscarinic M(3) receptor stimulation. Phosphatidylglycerols 72-75 cytochrome c oxidase II, mitochondrial Mus musculus 96-101 11743745-7 2001 Microarray analyses indicated that increased injury associated with COX-2 deficiency coincided, most notably, with a profoundly impaired induction of heat shock proteins in COX-2(-/+) mice suggesting that PGs may act as critical endogenous stress signals following drug insult. Phosphatidylglycerols 205-208 cytochrome c oxidase II, mitochondrial Mus musculus 68-73 21577211-12 2011 The present study therefore suggests that lymphangiogenesis, together with recurrence of lymph flow after surgical induction of lymphedema, is upregulated by COX-2 possibly via generation of PGs. Phosphatidylglycerols 191-194 cytochrome c oxidase II, mitochondrial Mus musculus 158-163 17583568-10 2007 Additionally, K14.COX2 mice treated only with DMBA developed approximately 3.5 times more tumors than wild-type mice, suggesting that PGs have intrinsic tumor promoting activity. Phosphatidylglycerols 134-137 cytochrome c oxidase II, mitochondrial Mus musculus 18-22 17187424-4 2007 In the present study, we demonstrate a protective role of COX-2 derived PGs in ConA-induced liver injury. Phosphatidylglycerols 72-75 cytochrome c oxidase II, mitochondrial Mus musculus 58-63 15883739-7 2005 Corresponding with the induction of COX-2 protein expression, the latter three PGs induced PGE2 synthesis in a dose-dependent manner. Phosphatidylglycerols 79-82 cytochrome c oxidase II, mitochondrial Mus musculus 36-41 11028754-10 2000 Precise analyses of the expression of COX-2 may disclose fine modulation of cellular and organ functions by PGs. Phosphatidylglycerols 108-111 cytochrome c oxidase II, mitochondrial Mus musculus 38-43 10828079-5 2000 We observed that AA and PGs induced COX-2, as well as COX-1, expression in cultured murine keratinocytes approximately 3 h after treatment. Phosphatidylglycerols 24-27 cytochrome c oxidase II, mitochondrial Mus musculus 36-41 10773011-4 2000 Brief exposure to NMDA (5 min; 100 microM) elicited a time-dependent accumulation of PGs in the culture medium that preceded neuronal cell death and correlated with the induction of COX-2 mRNA. Phosphatidylglycerols 85-88 cytochrome c oxidase II, mitochondrial Mus musculus 182-187 29676940-8 2018 Intriguingly, the highly expressed knockin COX-2 enzyme barely makes any PGs or thromboxane in neonatal P8 or adult mice, demonstrating that prostanoid biosynthesis requires native COX-1 and cannot be rescued by the knockin COX-2. Phosphatidylglycerols 73-76 cytochrome c oxidase II, mitochondrial Mus musculus 43-48