PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9450688-3	1997	Pharmacological experiments using mofezolac, a preferential inhibitor against COX-1, and NS-398, a selective inhibitor against COX-2, confirmed the involvement of COX-1 derived PGs in the induction of c-fos expression in the hind brain following the noxious stimulation.	Phosphatidylglycerols	177-180	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	163-168	
16172547-8	2005	We conclude that endogenous PGs derived from COX-1 are involved in the mucosal defense of the esophagus and that PGE2 has a biphasic influence on esophageal injury, depending on the dose: a protective effect at low doses and a deleterious effect at high doses, both mediated by EP1 receptors--the latter effect of PGE2 may be brought about by stimulation of the pepsin secretion.	Phosphatidylglycerols	28-31	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	45-50	
11133513-1	2001	The generation of PGs from arachidonic acid is mediated by cyclooxygenase (COX), which consists of a constitutive (COX-1) and an inducible (COX-2) isoform.	Phosphatidylglycerols	18-21	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	115-120	
9789085-1	1998	The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane.	Phosphatidylglycerols	155-158	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	51-56	
9353169-9	1997	The present study supports a mediator role for endogenous PGs in duodenal HCO3- secretion in response to mucosal acidification and suggests that COX-1 but not COX-2 is a key enzyme in regulating this process and maintaining the mucosal integrity against acid in the duodenum.	Phosphatidylglycerols	58-61	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	145-150	
16473424-3	2006	These non-steroidal anti-inflammatory drugs (NSAIDs) except for zaltoprofen, strongly inhibited an acetic acid-induced writhing response related to PGs based on COX-1, at lower doses.	Phosphatidylglycerols	148-151	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	161-166	
17229989-9	2006	These results support a mediator role for endogenous PGs in the gastric response induced by mucosal acidification and clearly indicate that the enzyme responsible for production of PGs in this process is COX-1.	Phosphatidylglycerols	53-56	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	204-209	
17229989-9	2006	These results support a mediator role for endogenous PGs in the gastric response induced by mucosal acidification and clearly indicate that the enzyme responsible for production of PGs in this process is COX-1.	Phosphatidylglycerols	181-184	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	204-209