PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27769711-5 2016 Esculetin treatment in diabetic mice fed HFD significantly down-regulated expression of lipid synthesis genes (Fasn, Dgat2 and Plpp2) and inflammation genes (Tlr4, Myd88, Nfkb, Tnfalpha and Il6). esculetin 0-9 interleukin 6 Mus musculus 190-193 26514440-3 2015 ES pretreatment at doses of 20 and 40 mg/kg effectively attenuated LPS-induced lung histopathological change, myeloperoxidase or MPO activity, inflammatory cells infiltration, pulmonary wet-to-dry weight ratio, and the generation of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in vivo and in vitro. esculetin 0-2 interleukin 6 Mus musculus 345-358 27133730-6 2016 Esculetin significantly reduced LPS-induced elevated levels of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in serum and hippocampus. esculetin 0-9 interleukin 6 Mus musculus 100-113 27133730-6 2016 Esculetin significantly reduced LPS-induced elevated levels of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in serum and hippocampus. esculetin 0-9 interleukin 6 Mus musculus 115-119 26514440-3 2015 ES pretreatment at doses of 20 and 40 mg/kg effectively attenuated LPS-induced lung histopathological change, myeloperoxidase or MPO activity, inflammatory cells infiltration, pulmonary wet-to-dry weight ratio, and the generation of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in vivo and in vitro. esculetin 0-2 interleukin 6 Mus musculus 360-364 32170603-5 2020 Pretreatment with esculetin significantly attenuated histopathological changes, inflammatory cell infiltration, and production of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6, in the lung tissue. esculetin 18-27 interleukin 6 Mus musculus 229-233