PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31646826-11 2019 Esculetin also triggered G0/G1 cell cycle arrest in HL-60 cells, which was also accompanied by suppression of Cyclin D1 and D3. esculetin 0-9 cyclin D1 Homo sapiens 110-119 21600278-9 2011 In conclusion, these results demonstrate that activation of p38 MAPK contributes to esculetin-induced p21WAF1 expression in VSMC by decreasing both the cyclin D1/CDK4 and cyclin E/CDK2 complexes. esculetin 84-93 cyclin D1 Homo sapiens 152-161 28789402-4 2017 Treatment of SMMC-7721 cells with esculetin resulted in downregulation of the mRNA and protein levels of beta-catenin, c-Myc and cyclin D1. esculetin 34-43 cyclin D1 Homo sapiens 129-138 26151043-6 2015 Notably, esculetin modulated Sp1 downstream target genes including p27, p21 and cyclin D1, resulted in activation of apoptosis signaling molecules such as caspase-3 and PARP in G361 HMM cells. esculetin 9-18 cyclin D1 Homo sapiens 80-89