PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31646826-11	2019	Esculetin also triggered G0/G1 cell cycle arrest in HL-60 cells, which was also accompanied by suppression of Cyclin D1 and D3.	esculetin	0-9	cyclin D1	Homo sapiens	110-119	
28789402-4	2017	Treatment of SMMC-7721 cells with esculetin resulted in downregulation of the mRNA and protein levels of beta-catenin, c-Myc and cyclin D1.	esculetin	34-43	cyclin D1	Homo sapiens	129-138	
26151043-6	2015	Notably, esculetin modulated Sp1 downstream target genes including p27, p21 and cyclin D1, resulted in activation of apoptosis signaling molecules such as caspase-3 and PARP in G361 HMM cells.	esculetin	9-18	cyclin D1	Homo sapiens	80-89	
21600278-9	2011	In conclusion, these results demonstrate that activation of p38 MAPK contributes to esculetin-induced p21WAF1 expression in VSMC by decreasing both the cyclin D1/CDK4 and cyclin E/CDK2 complexes.	esculetin	84-93	cyclin D1	Homo sapiens	152-161