PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26151043-5	2015	Interestingly, we found that esculetin induced nuclear shrinkage and fragmentation, typical apoptosis markers, by suppression of Sp1 transcription factor (Sp1).	esculetin	29-38	Sp1 transcription factor	Homo sapiens	129-153	
27901471-0	2017	Esculetin exerts anti-proliferative effects against non-small-cell lung carcinoma by suppressing specificity protein 1 in vitro.	esculetin	0-9	Sp1 transcription factor	Homo sapiens	97-118	
27901471-5	2017	Intriguingly, the transcription factor specificity protein 1 (Sp1) was significantly suppressed by esculetin in a dose- and time-dependent manner.	esculetin	99-108	Sp1 transcription factor	Homo sapiens	39-60	
25310400-2	2015	The purpose of the present study was to investigate the anti-proliferative effects of esculetin on two oral squamous cell carcinoma (OSCC) cell lines, HN22 and HSC4, through regulation of specificity protein 1 (Sp1).	esculetin	86-95	Sp1 transcription factor	Homo sapiens	188-209