PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28177662-0	2017	Esculetin induces apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-mediated mitochondrial pathways.	esculetin	0-9	insulin like growth factor 1	Homo sapiens	55-60	
28847482-0	2017	Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1/PI3K/Akt signaling pathway.	esculetin	0-9	insulin like growth factor 1	Homo sapiens	72-77	
28847482-4	2017	Further study showed that the pro-apoptotic effects of esculetin were associated with down-regulation of insulin-like growth factor-1/ phosphatidylinositide 3-kinase/protein kinase B (IGF-1/PI3K/Akt) signaling pathway.	esculetin	55-64	insulin like growth factor 1	Homo sapiens	184-189	
28847482-5	2017	Activation of IGF-1/PI3K/Akt pathway by IGF-1 abrogated the pro-apoptotic effects of esculetin, while inhibition of IGF-1/PI3K/Akt pathway by triciribine or LY294002 enhanced the pro-apoptotic effects of esculetin.	esculetin	85-94	insulin like growth factor 1	Homo sapiens	14-19	
28847482-5	2017	Activation of IGF-1/PI3K/Akt pathway by IGF-1 abrogated the pro-apoptotic effects of esculetin, while inhibition of IGF-1/PI3K/Akt pathway by triciribine or LY294002 enhanced the pro-apoptotic effects of esculetin.	esculetin	85-94	insulin like growth factor 1	Homo sapiens	40-45	
28847482-5	2017	Activation of IGF-1/PI3K/Akt pathway by IGF-1 abrogated the pro-apoptotic effects of esculetin, while inhibition of IGF-1/PI3K/Akt pathway by triciribine or LY294002 enhanced the pro-apoptotic effects of esculetin.	esculetin	85-94	insulin like growth factor 1	Homo sapiens	40-45	
28847482-5	2017	Activation of IGF-1/PI3K/Akt pathway by IGF-1 abrogated the pro-apoptotic effects of esculetin, while inhibition of IGF-1/PI3K/Akt pathway by triciribine or LY294002 enhanced the pro-apoptotic effects of esculetin.	esculetin	204-213	insulin like growth factor 1	Homo sapiens	14-19	
28847482-7	2017	CONCLUSION: These results indicate that esculetin could inhibit cell proliferation and induce apoptosis of gastric cancer cells through IGF-1/PI3K/Akt mediated mitochondrial apoptosis pathway, and may be a novel effective chemotherapeutic agent against gastric cancer.	esculetin	40-49	insulin like growth factor 1	Homo sapiens	136-141	
28177662-6	2017	In addition, the inactivation of IGF-1, PI3K, and Akt was observed after esculetin administration.	esculetin	73-82	insulin like growth factor 1	Homo sapiens	33-38	
28177662-7	2017	Furthermore, pretreatment with IGF-1 before esculetin administration abrogated the pro-apoptotic effects of esculetin, while PI3K inhibitor increased the pro-apoptotic effects of esculetin.	esculetin	108-117	insulin like growth factor 1	Homo sapiens	31-36	
28177662-7	2017	Furthermore, pretreatment with IGF-1 before esculetin administration abrogated the pro-apoptotic effects of esculetin, while PI3K inhibitor increased the pro-apoptotic effects of esculetin.	esculetin	108-117	insulin like growth factor 1	Homo sapiens	31-36	
28177662-8	2017	These results indicated that esculetin induced the apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-regulated mitochondrial dysfunction.	esculetin	29-38	insulin like growth factor 1	Homo sapiens	88-93