PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28177662-5	2017	Meanwhile, esculetin increased the activities of caspase-3 and caspase-9, promoted bax expression, decreased bcl-2 expression, and triggered collapse of mitochondrial membrane potential, and increased cytochrome c release from mitochondria.	esculetin	11-20	cytochrome c, somatic	Homo sapiens	201-213	
28847482-3	2017	Mechanism study indicated that esculetin induced gastric cancer MGC-803 cells apoptosis by triggering the activation of mitochondrial apoptotic pathway through reducing the mitochondrial membrane potential (MMP), increasing Bax/Bcl-2 ratio, activating caspase-3 and caspase-9 activity, and increasing cytochrome c release from mitochondria.	esculetin	31-40	cytochrome c, somatic	Homo sapiens	301-313	
29629344-10	2018	The induced expression of cytochrome c, p53, p21 and p27, and down-regulated CDK2 and CDK4 may be the underlying molecular mechanisms of esculetin effect.	esculetin	137-146	cytochrome c, somatic	Homo sapiens	26-38	
26508031-9	2016	Esculetin induced cytotoxicity that involved apoptosis, as supported by the reduction of mitochondrial membrane potential and the release of cytochrome c and the proteolytic activation of caspase-9/caspase-3, which were partially reversed by pre-chelating cytosolic Ca(2+) with 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxymethyl ester (BAPTA-AM).	esculetin	0-9	cytochrome c, somatic	Homo sapiens	141-153	
19428345-11	2009	The combined esculetin and As(2)O(3) treatment increased Bid cleavage, Bax conformation change and cytochrome C release.	esculetin	13-22	cytochrome c, somatic	Homo sapiens	99-111	
24995577-11	2014	Additionally, esculetin induced the loss of mitochondrial membrane potential with a release of cytochrome c into the cytosol which starts at 6 h of treatment with esculetin and increases up to 24 h. Esculetin induced an increase in superoxide anion at long times of treatment and a reduction of peroxides at short times (1 h) with an observed increase at 2-4 h of treatment.	esculetin	14-23	cytochrome c, somatic	Homo sapiens	95-107	
24995577-11	2014	Additionally, esculetin induced the loss of mitochondrial membrane potential with a release of cytochrome c into the cytosol which starts at 6 h of treatment with esculetin and increases up to 24 h. Esculetin induced an increase in superoxide anion at long times of treatment and a reduction of peroxides at short times (1 h) with an observed increase at 2-4 h of treatment.	esculetin	163-172	cytochrome c, somatic	Homo sapiens	95-107	
24995577-11	2014	Additionally, esculetin induced the loss of mitochondrial membrane potential with a release of cytochrome c into the cytosol which starts at 6 h of treatment with esculetin and increases up to 24 h. Esculetin induced an increase in superoxide anion at long times of treatment and a reduction of peroxides at short times (1 h) with an observed increase at 2-4 h of treatment.	esculetin	199-208	cytochrome c, somatic	Homo sapiens	95-107	
25818986-4	2015	Moreover, esculetin increased mitochondrial membrane depolarization, released cytochrome c into cytosol, and modulated the expression of apoptosis-associated proteins, resulting in reduced expression of B cell lymphoma-2, increased expression of Bcl-2-associated X protein, and activation of caspase-9 and caspase-3.	esculetin	10-19	cytochrome c, somatic	Homo sapiens	78-90	
18031783-5	2008	Esculetin-induced apoptosis was correlated with mitochondrial dysfunction, leading to the release of cytochrome c from the mitochondria to the cytosol, as well as the proteolytic activation of caspases.	esculetin	0-9	cytochrome c, somatic	Homo sapiens	101-113	
16051289-7	2006	Meanwhile, immunoblotting analysis also showed that the co-administration of esculetin and Taxol could increase the expression of Bax and the cytosolic release of cytochrome C and enhance the expression of Fas and Fas ligand while the activation of caspase-8 and caspase-3 was also increased.	esculetin	77-86	cytochrome c, somatic	Homo sapiens	163-175	
16699950-4	2006	Esculetin treatment also resulted in translocation of cytochrome c from mitochondria to cytosol and cleavage of 116 kDa poly(ADP-ribose) polymerase (PARP)-1, resulting in the accumulation of an 85 kDa cleavage product in a caspase-dependent manner.	esculetin	0-9	cytochrome c, somatic	Homo sapiens	54-66	
16699950-6	2006	In addition, an inhibitor of the JNK MAP kinase pathway, SP600125, reduced esculetin-induced cytochrome c release.	esculetin	75-84	cytochrome c, somatic	Homo sapiens	93-105	
11282109-5	2001	Further investigation showed that esculetin induced the release of cytochrome c from mitochondria into cytosol in a time-dependent and concentration-dependent manner.	esculetin	34-43	cytochrome c, somatic	Homo sapiens	67-79	
11282109-8	2001	These data suggest that esculetin induces apoptosis in human leukemia cells by increasing cytosolic translocation of cytochrome c and activation of CPP32.	esculetin	24-33	cytochrome c, somatic	Homo sapiens	117-129