PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34266475-14	2021	In H9C2 cell lines esculetin could effectively reduced intracellular ROS inhibition and m-RNA expression of pro-inflammatory cytokines including TNF-alpha, IL-6 and NF-kappaB to prevent apoptosis or cell necrosis.	esculetin	19-28	interleukin 6	Rattus norvegicus	156-160	
32186137-14	2018	Compared with the sham group, the esculetin group had significantly decreased serum levels of IL-6 and RANKL, and significant downregulation of RANKL protein and mRNA expression levels in osteoblasts and bone marrow stromal cells; however, there was no significant difference between groups in OPG.	esculetin	34-43	interleukin 6	Rattus norvegicus	94-98	
32186137-15	2018	CONCLUSION: Esculetin can increase bone mass by upregulating RANKL expression in osteoblasts and bone marrow stromal cells, and decreasing serum IL-6 concentration.	esculetin	12-21	interleukin 6	Rattus norvegicus	145-149