PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32186137-14 2018 Compared with the sham group, the esculetin group had significantly decreased serum levels of IL-6 and RANKL, and significant downregulation of RANKL protein and mRNA expression levels in osteoblasts and bone marrow stromal cells; however, there was no significant difference between groups in OPG. esculetin 34-43 interleukin 6 Rattus norvegicus 94-98 32186137-15 2018 CONCLUSION: Esculetin can increase bone mass by upregulating RANKL expression in osteoblasts and bone marrow stromal cells, and decreasing serum IL-6 concentration. esculetin 12-21 interleukin 6 Rattus norvegicus 145-149 34266475-14 2021 In H9C2 cell lines esculetin could effectively reduced intracellular ROS inhibition and m-RNA expression of pro-inflammatory cytokines including TNF-alpha, IL-6 and NF-kappaB to prevent apoptosis or cell necrosis. esculetin 19-28 interleukin 6 Rattus norvegicus 156-160