PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24995577-9 2014 Proapoptotic action of esculetin involves the ERK MAP kinase cascade since increased levels of phosphorylated ERK were observed after those treatments. esculetin 23-32 mitogen-activated protein kinase 1 Homo sapiens 46-49 31646826-0 2019 In vitro anticancer effects of esculetin against human leukemia cell lines involves apoptotic cell death, autophagy, G0/G1 cell cycle arrest and modulation of Raf/MEK/ERK signalling pathway. esculetin 31-40 mitogen-activated protein kinase 1 Homo sapiens 167-170 31646826-12 2019 Esculetin could also block the Raf/MEK/ERK signalling pathway in leukemia cells in a concentration-dependent manner. esculetin 0-9 mitogen-activated protein kinase 1 Homo sapiens 39-42 24995577-9 2014 Proapoptotic action of esculetin involves the ERK MAP kinase cascade since increased levels of phosphorylated ERK were observed after those treatments. esculetin 23-32 mitogen-activated protein kinase 1 Homo sapiens 110-113 22581442-4 2012 Esculetin activated the MAPKs (ERK1/2, p38, JNK) and PI3K/Akt pathways, through which it promoted the type I procollagen expression. esculetin 0-9 mitogen-activated protein kinase 1 Homo sapiens 39-42 21600278-0 2011 p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation. esculetin 36-45 mitogen-activated protein kinase 1 Homo sapiens 0-3 21600278-3 2011 The present results suggest an unexpected role of the p38 MAPK signaling pathway in esculetin-induced inhibition of VSMC growth. esculetin 84-93 mitogen-activated protein kinase 1 Homo sapiens 54-57 21600278-6 2011 In addition, esculetin treatment activated p38 MAPK and ERK1/2. esculetin 13-22 mitogen-activated protein kinase 1 Homo sapiens 43-46 21600278-7 2011 Pretreatment with SB203580, which is a p38 MAPK specific inhibitor, or expression of the dominant negative p38 MAPK (DN p38 MAPK) gene blocked esculetin-induced p38 MAPK activation and p21WAF1 expression. esculetin 143-152 mitogen-activated protein kinase 1 Homo sapiens 39-42 21600278-7 2011 Pretreatment with SB203580, which is a p38 MAPK specific inhibitor, or expression of the dominant negative p38 MAPK (DN p38 MAPK) gene blocked esculetin-induced p38 MAPK activation and p21WAF1 expression. esculetin 143-152 mitogen-activated protein kinase 1 Homo sapiens 107-110 21600278-7 2011 Pretreatment with SB203580, which is a p38 MAPK specific inhibitor, or expression of the dominant negative p38 MAPK (DN p38 MAPK) gene blocked esculetin-induced p38 MAPK activation and p21WAF1 expression. esculetin 143-152 mitogen-activated protein kinase 1 Homo sapiens 107-110 21600278-7 2011 Pretreatment with SB203580, which is a p38 MAPK specific inhibitor, or expression of the dominant negative p38 MAPK (DN p38 MAPK) gene blocked esculetin-induced p38 MAPK activation and p21WAF1 expression. esculetin 143-152 mitogen-activated protein kinase 1 Homo sapiens 107-110 21600278-8 2011 Finally, both the growth inhibition and the down-regulation of CDKs induced by esculetin were suppressed by either SB203580 or the DN p38 MAPK mutant gene. esculetin 79-88 mitogen-activated protein kinase 1 Homo sapiens 134-137 19786087-0 2010 Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling. esculetin 26-35 mitogen-activated protein kinase 1 Homo sapiens 85-115 21600278-9 2011 In conclusion, these results demonstrate that activation of p38 MAPK contributes to esculetin-induced p21WAF1 expression in VSMC by decreasing both the cyclin D1/CDK4 and cyclin E/CDK2 complexes. esculetin 84-93 mitogen-activated protein kinase 1 Homo sapiens 60-63 19786087-3 2010 Combined treatment with esculetin and HA14-1 upregulated the expression of death receptor 4 (DR4), and activation of extracellular-regulated kinase (ERK) in a time-dependent manner. esculetin 24-33 mitogen-activated protein kinase 1 Homo sapiens 117-147 19786087-3 2010 Combined treatment with esculetin and HA14-1 upregulated the expression of death receptor 4 (DR4), and activation of extracellular-regulated kinase (ERK) in a time-dependent manner. esculetin 24-33 mitogen-activated protein kinase 1 Homo sapiens 149-152 16051289-5 2006 Firstly, esculetin alone could exert an antiproliferation effect together with an inhibitory effect on the activation of ERKs and p38 MAPK. esculetin 9-18 mitogen-activated protein kinase 1 Homo sapiens 121-125 19786087-4 2010 In addition, esculetin and HA14-1-mediated apoptosis was reduced by ERK inhibitors through inhibition of DR4 expression, suggesting that the synergistic effect was at least partially mediated through ERK-dependent induction of DR4 expression. esculetin 13-22 mitogen-activated protein kinase 1 Homo sapiens 68-71 19786087-4 2010 In addition, esculetin and HA14-1-mediated apoptosis was reduced by ERK inhibitors through inhibition of DR4 expression, suggesting that the synergistic effect was at least partially mediated through ERK-dependent induction of DR4 expression. esculetin 13-22 mitogen-activated protein kinase 1 Homo sapiens 200-203 19786087-5 2010 The results indicate that HA14-1-induced reversal of the anti-apoptotic effect of Bcl-2 confers apoptosis sensitivity to esculetin by a mitochondrial amplification step and through the ERK-dependent induction of DR4 expression in U937/Bcl-2 cells. esculetin 121-130 mitogen-activated protein kinase 1 Homo sapiens 185-188 19428345-14 2009 Based on these studies, esculetin enhances the As(2)O(3)-provoked apoptosis by modulating the MEK/ERK and JNK pathways and reducing intracellular GSH levels. esculetin 24-33 mitogen-activated protein kinase 1 Homo sapiens 98-101 18031783-0 2008 Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK. esculetin 26-35 mitogen-activated protein kinase 1 Homo sapiens 95-98 18031783-7 2008 Furthermore, esculetin selectively increased the phosphorylation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), but not that of other kinases such as Akt and p38 activation. esculetin 13-22 mitogen-activated protein kinase 1 Homo sapiens 68-98 18031783-7 2008 Furthermore, esculetin selectively increased the phosphorylation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), but not that of other kinases such as Akt and p38 activation. esculetin 13-22 mitogen-activated protein kinase 1 Homo sapiens 100-103 18031783-8 2008 In addition, an ERK-specific inhibitor, PD98059, and a JNK-specific inhibitor, SP600125, showed inhibited sub-G1 phase DNA content, DNA fragmentation, caspase activation, and mitochondrial dysfunction induced by esculetin treatment. esculetin 212-221 mitogen-activated protein kinase 1 Homo sapiens 16-19 18031783-9 2008 These results indicated that the JNK and ERK pathways were key regulators of apoptosis in response to esculetin in human leukemia U937 cells. esculetin 102-111 mitogen-activated protein kinase 1 Homo sapiens 41-44 16051289-8 2006 Finally, the ERK cascade was proven to be involved in the enhancement of esculetin on the Taxol-induced apoptosis. esculetin 73-82 mitogen-activated protein kinase 1 Homo sapiens 13-16