PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19472295-3	2009	The results revealed that PD, anemonin, berberine, and esculetin inhibited the production of NO; PD, anemonin, and esculetin inhibited the secretion of ET-1; PD, anemoside B(4), berberine, jatrorrhizine, and aesculin downregulated TNF-alpha expression; PD, anemoside B(4), berberine, and palmatine decreased the content of IL-1 alpha.	esculetin	55-64	interleukin 1 alpha	Rattus norvegicus	323-333	
19472295-3	2009	The results revealed that PD, anemonin, berberine, and esculetin inhibited the production of NO; PD, anemonin, and esculetin inhibited the secretion of ET-1; PD, anemoside B(4), berberine, jatrorrhizine, and aesculin downregulated TNF-alpha expression; PD, anemoside B(4), berberine, and palmatine decreased the content of IL-1 alpha.	esculetin	115-124	interleukin 1 alpha	Rattus norvegicus	323-333	
35448455-5	2022	Brain IL-1beta and TNF-alpha levels were elevated after ZnO NP administration, and these effects were inhibited by esculetin and fucoidan.	esculetin	115-124	interleukin 1 alpha	Rattus norvegicus	6-14