PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21109980-4	2011	The treatment of cells with esculetin resulted in significant growth inhibition and G1 phase cell cycle arrest, which led to the down-regulation of cyclin and cyclin-dependent kinase (CDK) expressions.	esculetin	28-37	proliferating cell nuclear antigen	Homo sapiens	148-154	
21109980-4	2011	The treatment of cells with esculetin resulted in significant growth inhibition and G1 phase cell cycle arrest, which led to the down-regulation of cyclin and cyclin-dependent kinase (CDK) expressions.	esculetin	28-37	proliferating cell nuclear antigen	Homo sapiens	159-165	
21109980-12	2011	In conclusion, these results indicate that the Ras/ERK1/2 pathway is mediated by the p27KIP1 induction, leading to a reduction in cyclin/CDK complexes in the esculetin-induced inhibition of colon cancer cell growth.	esculetin	158-167	proliferating cell nuclear antigen	Homo sapiens	130-136