PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21600278-8	2011	Finally, both the growth inhibition and the down-regulation of CDKs induced by esculetin were suppressed by either SB203580 or the DN p38 MAPK mutant gene.	esculetin	79-88	cyclin dependent kinase 2	Homo sapiens	63-67	
21600278-9	2011	In conclusion, these results demonstrate that activation of p38 MAPK contributes to esculetin-induced p21WAF1 expression in VSMC by decreasing both the cyclin D1/CDK4 and cyclin E/CDK2 complexes.	esculetin	84-93	cyclin dependent kinase 2	Homo sapiens	180-184	
18222060-3	2008	Cells that were treated with esculetin showed increased binding of p21 with Cdk2 and Cdk4 that was paralleled by a marked decrease in the Cdk2 and Cdk4 kinase activities with no change in their expression.	esculetin	29-38	cyclin dependent kinase 2	Homo sapiens	76-80	
18222060-3	2008	Cells that were treated with esculetin showed increased binding of p21 with Cdk2 and Cdk4 that was paralleled by a marked decrease in the Cdk2 and Cdk4 kinase activities with no change in their expression.	esculetin	29-38	cyclin dependent kinase 2	Homo sapiens	138-142	
29629344-10	2018	The induced expression of cytochrome c, p53, p21 and p27, and down-regulated CDK2 and CDK4 may be the underlying molecular mechanisms of esculetin effect.	esculetin	137-146	cyclin dependent kinase 2	Homo sapiens	77-81