PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27756327-4 2016 The interaction between transcription factor, Nrf2 and its regulator KEAP1 was studied in the presence and absence of esculetin. esculetin 118-127 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 27756327-10 2016 Interaction between Nrf2 and KEAP1 was found to be lost upon esculetin treatment in PANC-1 and MIA Paca-2 cells. esculetin 61-70 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 27756327-11 2016 Nuclear accumulation of Nrf2 and an upregulation of expression of Nrf2 regulated gene NQO1, observed on esculetin treatment in PANC-1 further supported the activation of Nrf2. esculetin 104-113 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 27756327-11 2016 Nuclear accumulation of Nrf2 and an upregulation of expression of Nrf2 regulated gene NQO1, observed on esculetin treatment in PANC-1 further supported the activation of Nrf2. esculetin 104-113 NFE2 like bZIP transcription factor 2 Homo sapiens 66-70 27756327-11 2016 Nuclear accumulation of Nrf2 and an upregulation of expression of Nrf2 regulated gene NQO1, observed on esculetin treatment in PANC-1 further supported the activation of Nrf2. esculetin 104-113 NFE2 like bZIP transcription factor 2 Homo sapiens 66-70 27756327-12 2016 To account for the loss of Nrf2-KEAP1 interaction on esculetin treatment, direct binding potential between esculetin and KEAP1 was depicted in silico using molecular docking studies. esculetin 53-62 NFE2 like bZIP transcription factor 2 Homo sapiens 27-31 27756327-12 2016 To account for the loss of Nrf2-KEAP1 interaction on esculetin treatment, direct binding potential between esculetin and KEAP1 was depicted in silico using molecular docking studies. esculetin 107-116 NFE2 like bZIP transcription factor 2 Homo sapiens 27-31 27756327-14 2016 CONCLUSIONS: We propose that esculetin binds to KEAP1 and inhibits its interaction with Nrf2 in pancreatic cancer cells. esculetin 29-38 NFE2 like bZIP transcription factor 2 Homo sapiens 88-92 30171828-0 2018 Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. esculetin 74-83 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 20933534-0 2011 Esculetin-induced protection of human hepatoma HepG2 cells against hydrogen peroxide is associated with the Nrf2-dependent induction of the NAD(P)H: Quinone oxidoreductase 1 gene. esculetin 0-9 NFE2 like bZIP transcription factor 2 Homo sapiens 108-112 20933534-9 2011 Esculetin treatment also increased nuclear accumulation of Nrf2 by 8-fold indicating that increased NQO1 expression is Nrf2-mediated. esculetin 0-9 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 20933534-9 2011 Esculetin treatment also increased nuclear accumulation of Nrf2 by 8-fold indicating that increased NQO1 expression is Nrf2-mediated. esculetin 0-9 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 20933534-10 2011 These results indicate that esculetin protects human hepatoma HepG2 cells from hydrogen peroxide induced oxidative injury and that this protection is provided through the induction of protective enzymes as part of an adaptive response mediated by Nrf2 nuclear accumulation. esculetin 28-37 NFE2 like bZIP transcription factor 2 Homo sapiens 247-251 33220236-0 2021 Esculetin protects human corneal epithelial cells from oxidative stress through Nrf-2 signaling pathway. esculetin 0-9 NFE2 like bZIP transcription factor 2 Homo sapiens 80-85 33220236-5 2021 Our data revealed that esculetin played an antioxidant role not only through its antioxidant activity, but also by highly inducing Nrf-2 translocation to the nucleus, which in turn, enhanced Nrf2 signaling regulated antioxidant genes (HO-1, NQO1, GCLM, SOD1 and SOD2) mRNA expression levels in H2O2-treated HCE cells. esculetin 23-32 NFE2 like bZIP transcription factor 2 Homo sapiens 131-136 33220236-5 2021 Our data revealed that esculetin played an antioxidant role not only through its antioxidant activity, but also by highly inducing Nrf-2 translocation to the nucleus, which in turn, enhanced Nrf2 signaling regulated antioxidant genes (HO-1, NQO1, GCLM, SOD1 and SOD2) mRNA expression levels in H2O2-treated HCE cells. esculetin 23-32 NFE2 like bZIP transcription factor 2 Homo sapiens 191-195 33220236-7 2021 These data illustrated, for the first time, that esculetin may have the ability to protect human corneal epithelial cells from oxidative damages through its scavenging of free radical properties and through the activation of Nrf2 signaling. esculetin 49-58 NFE2 like bZIP transcription factor 2 Homo sapiens 225-229 30171828-7 2018 A significant increase of Nrf2 in the nucleus of NB4 cells treated with 100 muM esculetin for 19 h was observed. esculetin 80-89 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 30171828-10 2018 All these data support a relevant differential role for NFkB and Nrf2 in anti-inflammatory and redox response when apoptosis was induced by esculetin or quercetin in human leukemia NB4 cells. esculetin 140-149 NFE2 like bZIP transcription factor 2 Homo sapiens 65-69