PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19786087-2 2010 The combined use of esculetin and HA14-1 effectively induced Bid cleavage and loss of mitochondrial membrane potential (MMP, Deltapsi(m)) leading to the activation of caspases and cleavage of poly(ADP-ribose) polymerase (PARP) in Bcl-2-overexpressing (U937/Bcl-2) cells. esculetin 20-29 poly(ADP-ribose) polymerase 1 Homo sapiens 192-219 19786087-2 2010 The combined use of esculetin and HA14-1 effectively induced Bid cleavage and loss of mitochondrial membrane potential (MMP, Deltapsi(m)) leading to the activation of caspases and cleavage of poly(ADP-ribose) polymerase (PARP) in Bcl-2-overexpressing (U937/Bcl-2) cells. esculetin 20-29 poly(ADP-ribose) polymerase 1 Homo sapiens 221-225 26151043-6 2015 Notably, esculetin modulated Sp1 downstream target genes including p27, p21 and cyclin D1, resulted in activation of apoptosis signaling molecules such as caspase-3 and PARP in G361 HMM cells. esculetin 9-18 poly(ADP-ribose) polymerase 1 Homo sapiens 169-173 16699950-4 2006 Esculetin treatment also resulted in translocation of cytochrome c from mitochondria to cytosol and cleavage of 116 kDa poly(ADP-ribose) polymerase (PARP)-1, resulting in the accumulation of an 85 kDa cleavage product in a caspase-dependent manner. esculetin 0-9 poly(ADP-ribose) polymerase 1 Homo sapiens 120-156