PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1375638-16 1992 The combined application of a cyclo-oxygenase inhibitor, indomethacin (50 microM), and a lipoxygenase inhibitor, esculetin (100 microM), increased the Cl- current, whereas the administration of a phospholipase A2 inhibitor, mepacrine (100 microM), significantly decreased the whole-cell Cl- current. esculetin 113-122 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 89-101 8359208-10 1993 These results suggest that the antiproliferative effect of esculetin on vascular smooth muscle cells may be partly mediated through inhibition of protein tyrosine kinase and modulated by inhibition of lipoxygenase. esculetin 59-68 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 201-213