PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23706115-9 2013 However, chains with an odd-number of carbon atoms, C17, C19, , have very intense transitions in the region above 4400 A and remain attractive candidates. Carbon 38-44 cytokine like 1 Homo sapiens 52-55 16797024-7 2006 The carboxylic group at the C-2 carbon cannot interact with tetraalkylammonium cations as strongly as does the C-17 carboxylic group, leading to different effects in the absence of carboxylic group at the C-2 or C-17 carbon in the molecules. Carbon 217-223 cytokine like 1 Homo sapiens 111-115 21232955-3 2011 Compound 1, characterized by the presence of a C-16/C-17, C-20/C-21 conjugated diene and a C-1/C-7 ester bridge formed in rings A and B, provided a novel structural skeleton for 3,4-secocycloartane triterpenoid derivatives. Carbon 0-1 cytokine like 1 Homo sapiens 52-56 21232955-3 2011 Compound 1, characterized by the presence of a C-16/C-17, C-20/C-21 conjugated diene and a C-1/C-7 ester bridge formed in rings A and B, provided a novel structural skeleton for 3,4-secocycloartane triterpenoid derivatives. Carbon 47-48 cytokine like 1 Homo sapiens 52-56 16914311-9 2006 Central to these new renditions is the hypothesis that the appropriate P-450 introduces dioxygen into the precursor yielding either: A, a 20 peroxy sterol species or B, a species oxygenated at both C-17 and C-20 or C, a species oxygenated at both C-20 and C-21. Carbon 0-1 cytokine like 1 Homo sapiens 198-202 11948019-5 2002 The optimal side-chain length for the inhibition of steroid sulfatase activity was found to be six carbons, which corresponds to the number of carbons that mimic the B, C and D steroid rings, between C6 and C17. Carbon 99-106 cytokine like 1 Homo sapiens 207-210 12372858-4 2002 The key reaction involved one-step remote oxyfunctionalization of unactivated methine carbons at C-17 of CDCA and at C-14 of UDCA as their methyl ester-peracetate derivatives with dimethyldioxirane (DMDO). Carbon 86-93 cytokine like 1 Homo sapiens 97-101 12175241-3 2002 It was constructed anticipating an intramolecular displacement of the carbon (C17)-oxygen (O4) bond (see product 48). Carbon 70-76 cytokine like 1 Homo sapiens 78-81 16508916-3 2006 Notably, most of the 13C resonances of the taxane ring have two clearly resolved spectral components except the resonance peaks of C-15, C-16 and C-17, which are located at the central part of the taxane ring. Carbon 23-24 cytokine like 1 Homo sapiens 146-150 12117615-2 2002 The reactions are regio- and stereoselective; in fact, in the presence of more than one C=O group, the oxido or aziridino functions are formed uniquely at the C=O of C-17 (or C-20 depending on its position in the starting molecule), and the C-20(R) stereoisomer is often the only product isolated. Carbon 88-89 cytokine like 1 Homo sapiens 166-170 12117615-2 2002 The reactions are regio- and stereoselective; in fact, in the presence of more than one C=O group, the oxido or aziridino functions are formed uniquely at the C=O of C-17 (or C-20 depending on its position in the starting molecule), and the C-20(R) stereoisomer is often the only product isolated. Carbon 159-160 cytokine like 1 Homo sapiens 166-170 8935632-12 1996 3) The type in which a cis-diaxial-diol side chain in the alpha side of C-16 and C-17 positions of the ring D or its ketal blocking group seems to be associated with the reaction. Carbon 72-73 cytokine like 1 Homo sapiens 81-85 11543681-2 2001 Saturation of the double bond between C-17 and C-20 of fusidic acid produces four stereoisomers differing in the configuration at C-17 and C-20. Carbon 38-39 cytokine like 1 Homo sapiens 130-134 11543681-2 2001 Saturation of the double bond between C-17 and C-20 of fusidic acid produces four stereoisomers differing in the configuration at C-17 and C-20. Carbon 47-48 cytokine like 1 Homo sapiens 130-134 11179732-7 2001 The preferred conformations, inferred from an analysis of (13)C-NMR characteristics, notably the chemical shift of C-17 in a series of analogs, to have the tertiary alcohol (1"-hydroxy-1"-methylethyl) substituent equatorial on the cyclohexane chair, are confirmed by molecular modeling. Carbon 62-63 cytokine like 1 Homo sapiens 115-119 10717647-9 2000 Protonated oximes of 20-oxosteroids unsubstituted at C-21, C-17 or C-16 produced a characteristic ion at m/z 86 containing the side chain, C-16 and C-17. Carbon 53-54 cytokine like 1 Homo sapiens 148-152 10717647-9 2000 Protonated oximes of 20-oxosteroids unsubstituted at C-21, C-17 or C-16 produced a characteristic ion at m/z 86 containing the side chain, C-16 and C-17. Carbon 59-60 cytokine like 1 Homo sapiens 148-152 1838313-4 1991 We suggest that the C17 side chain is involved in protein binding and subsequent presentation of antigenic sites on the carbon rings. Carbon 120-126 cytokine like 1 Homo sapiens 20-23 1159711-3 1975 [The C-17 position is the carbon attached to C-8 of the ergoline (1) skeleton as indicated in structure 2.] Carbon 26-32 cytokine like 1 Homo sapiens 5-9 2085676-4 1990 Changes to the progesterone structure at C-17, C-20, or C-21 interfered with binding. Carbon 0-1 cytokine like 1 Homo sapiens 41-45 34487922-3 2021 Meanwhile, the oxidation of C-18 methyl to carboxyl group forms a 18,20-lactone, and the oxidation of C-14 and C-17 gets a heterocyclic oxygen acrossing rings C and D. Additionly, physalins frequently form an oxygen bridge to connect C-14 to C-27. Carbon 102-103 cytokine like 1 Homo sapiens 111-115 34487922-3 2021 Meanwhile, the oxidation of C-18 methyl to carboxyl group forms a 18,20-lactone, and the oxidation of C-14 and C-17 gets a heterocyclic oxygen acrossing rings C and D. Additionly, physalins frequently form an oxygen bridge to connect C-14 to C-27. Carbon 234-235 cytokine like 1 Homo sapiens 111-115 34487922-3 2021 Meanwhile, the oxidation of C-18 methyl to carboxyl group forms a 18,20-lactone, and the oxidation of C-14 and C-17 gets a heterocyclic oxygen acrossing rings C and D. Additionly, physalins frequently form an oxygen bridge to connect C-14 to C-27. Carbon 242-243 cytokine like 1 Homo sapiens 111-115 6456145-8 1981 The most effective inhibitors were the all-trans C17-aldehyde (beta-ionylideneacetaldehyde) or C18-ketone (beta-ionylidenepent-3-ene-2-one) which, compared to retinal, lack two or three carbon atoms from the end of the poylene chain. Carbon 186-192 cytokine like 1 Homo sapiens 49-52 970695-4 1976 It catalyses the transformation into ketone of the secondary alcohol group at the 3 beta position of sterols which possess in the C17 position a lateral chain of at least two carbon atoms. Carbon 175-181 cytokine like 1 Homo sapiens 130-133 35163908-4 2022 The Mo species, moreover, led to a decrease in the (C15 + C17)/(C16 + C18) ratio, which is beneficial from the viewpoint of carbon atom economy. Carbon 124-130 cytokine like 1 Homo sapiens 58-61 315415-4 1979 Urushiol is a mixture of alkylcatechols composed of a catechol ring coupled to mono-, di-, or tri-unsaturated C-15 or C-17 carbon side chains. Carbon 123-129 cytokine like 1 Homo sapiens 118-122 5275374-3 1970 This reaction can be formulated as an abstraction of hydrogen from the C-21-hydroxyl group to form a C-21-alkoxy radical, followed by a 1,5-H.shift from the C-16 atom and beta-scission of the C-16-alkoxy radical leading to the loss of a C(2) fragment (C-20 and C-21) with the formation of the double bond between C-16 and C-17. Carbon 71-72 cytokine like 1 Homo sapiens 322-326 5275374-3 1970 This reaction can be formulated as an abstraction of hydrogen from the C-21-hydroxyl group to form a C-21-alkoxy radical, followed by a 1,5-H.shift from the C-16 atom and beta-scission of the C-16-alkoxy radical leading to the loss of a C(2) fragment (C-20 and C-21) with the formation of the double bond between C-16 and C-17. Carbon 101-102 cytokine like 1 Homo sapiens 322-326 31022583-2 2019 Herein, a series of Cucurbitacin inspired estrone analogs was assembled to generate 18 novel synthesized analogs via installation of double bond across C-16/C-17 positions of estrone scaffold and diastereomeric separation of (R) and (S) at C-20. Carbon 20-21 cytokine like 1 Homo sapiens 157-161 31022583-2 2019 Herein, a series of Cucurbitacin inspired estrone analogs was assembled to generate 18 novel synthesized analogs via installation of double bond across C-16/C-17 positions of estrone scaffold and diastereomeric separation of (R) and (S) at C-20. Carbon 152-153 cytokine like 1 Homo sapiens 157-161 27687857-2 2017 Compound 1 has a alpha,beta-unsaturated-gamma-lactone ring conjugated with the C-22/23 olefin in the C-17 side chain. Carbon 0-1 cytokine like 1 Homo sapiens 101-105 28177243-1 2017 The absolute configuration at C-17, the carbon bearing the distal hydroxy group of the 14-membered natural product gliomasolide D, was assigned as R by comparison of 13C NMR shifts and specific rotation values of the epimers at C-17. Carbon 40-46 cytokine like 1 Homo sapiens 30-34 28177243-1 2017 The absolute configuration at C-17, the carbon bearing the distal hydroxy group of the 14-membered natural product gliomasolide D, was assigned as R by comparison of 13C NMR shifts and specific rotation values of the epimers at C-17. Carbon 40-46 cytokine like 1 Homo sapiens 228-232 26842424-3 2016 The stereogenic carbons were elaborated by desymmetrization for C12, allylation for C13, vanadyl-induced epoxidation for C16, Zn(BH4)2 reduction for C17, a chiral building block for C18 and C24, Shi epoxidation for C20 and C21, Myers" alkylation for C22, and thermodynamic control for C25. Carbon 16-23 cytokine like 1 Homo sapiens 149-152 25545348-12 2015 Moreover one metabolite resulting from cleavage of the side chain with subsequent oxidation of carbon at C17 was also detected. Carbon 95-101 cytokine like 1 Homo sapiens 105-108 25845933-1 2015 Novel 16-triazoles in the 13alpha-estrone series were synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition of the two diastereomeric (on C-16 and on C-17) 16-azido-13alpha-estra-1,3,5(10)-trien-17-ol 3-benzyl ethers with substituted phenylacetylenes. Carbon 70-71 cytokine like 1 Homo sapiens 155-159 25089242-3 2014 Compounds 1 and 2, two new decaoxygenated limonoids with a C-19/29 lactol bridge and heptaoxygenated substituents at C-1, C-2, C-3, C-7, C-11, C-17, and C-30, represent the second example of limonoids in the Euphorbiaceae family. Carbon 0-1 cytokine like 1 Homo sapiens 143-147 24666432-6 2014 Relative abundance patterns of carbon number are C10 > C11 > C12 ~ C13 for SCCPs and C14 > C15 > C16 C17 for MCCP with similarity to the profiles of samples from China, the biggest CPs producer in the world. Carbon 31-37 cytokine like 1 Homo sapiens 113-116