PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20164309-2 2010 Methylenetetrahydrofolate reductase (MTHFR), choline, and riboflavin play distinct roles in homocysteine detoxification and generation of one-carbon donors for methylation. Carbon 142-148 methylenetetrahydrofolate reductase Mus musculus 0-35 25733650-12 2015 Expression changes in genes of one-carbon and lipid metabolism were particularly significant in FASD Mthfr(+/-) mice. Carbon 35-41 methylenetetrahydrofolate reductase Mus musculus 101-106 23123153-2 2012 Methylenetetrahydrofolate reductase (Mthfr) plays a key role in folate metabolism by channeling one-carbon units between nucleotide synthesis and methylation reactions. Carbon 100-106 methylenetetrahydrofolate reductase Mus musculus 0-35 23123153-2 2012 Methylenetetrahydrofolate reductase (Mthfr) plays a key role in folate metabolism by channeling one-carbon units between nucleotide synthesis and methylation reactions. Carbon 100-106 methylenetetrahydrofolate reductase Mus musculus 37-42 25188266-5 2014 We also found that one-carbon metabolism (OCM) impairment plays a significant role in alcohol toxicity to the PFC seen from the difference in the effects of acute and chronic alcohol exposure on DNA repair and from exaggeration of the damaging effects upon additional OCM impairment in mice deficient in a key OCM enzyme, methylenetetrahydrofolate reductase (MTHFR). Carbon 23-29 methylenetetrahydrofolate reductase Mus musculus 322-357 25188266-5 2014 We also found that one-carbon metabolism (OCM) impairment plays a significant role in alcohol toxicity to the PFC seen from the difference in the effects of acute and chronic alcohol exposure on DNA repair and from exaggeration of the damaging effects upon additional OCM impairment in mice deficient in a key OCM enzyme, methylenetetrahydrofolate reductase (MTHFR). Carbon 23-29 methylenetetrahydrofolate reductase Mus musculus 359-364 21769670-1 2011 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, synthesizes 5-methyltetrahydrofolate, the main circulatory form of folate which is required for maintaining nontoxic levels of homocysteine and providing one-carbon units for methylation. Carbon 238-244 methylenetetrahydrofolate reductase Mus musculus 0-35 21769670-1 2011 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, synthesizes 5-methyltetrahydrofolate, the main circulatory form of folate which is required for maintaining nontoxic levels of homocysteine and providing one-carbon units for methylation. Carbon 238-244 methylenetetrahydrofolate reductase Mus musculus 37-42 20164309-2 2010 Methylenetetrahydrofolate reductase (MTHFR), choline, and riboflavin play distinct roles in homocysteine detoxification and generation of one-carbon donors for methylation. Carbon 142-148 methylenetetrahydrofolate reductase Mus musculus 37-42 17937387-5 2007 A real-time polymerase chain reaction analysis of 10 genes in the one-carbon metabolism pathway revealed that 5,10-methylenetetrahydrofolate reductase, S-adenosylhomocysteine hydrolase (Ahcy), and formiminotransferase cyclodeaminase (Ftcd) were significantly down-regulated in Gnmt-/- mice. Carbon 70-76 methylenetetrahydrofolate reductase Mus musculus 110-150 31794432-6 2020 Furthermore, ventriculomegaly was rescued by genetic ablation of 5,10-methylene tetrahydrofolate reductase (Mthfr), which results in retention of 1-carbon groups in the folate cycle at the expense of transfer to the methylation cycle. Carbon 148-154 methylenetetrahydrofolate reductase Mus musculus 65-106 35409465-7 2022 Thereafter, the association between methylenetetrahydrofolate reductase (Mthfr a key enzyme in one-carbon metabolism and DNA-methylation-induced regulation of gene transcription) and lipogenic genes was evaluated using Pearson"s correlation coefficient. Carbon 99-105 methylenetetrahydrofolate reductase Mus musculus 36-71 35409465-7 2022 Thereafter, the association between methylenetetrahydrofolate reductase (Mthfr a key enzyme in one-carbon metabolism and DNA-methylation-induced regulation of gene transcription) and lipogenic genes was evaluated using Pearson"s correlation coefficient. Carbon 99-105 methylenetetrahydrofolate reductase Mus musculus 73-78 31794432-6 2020 Furthermore, ventriculomegaly was rescued by genetic ablation of 5,10-methylene tetrahydrofolate reductase (Mthfr), which results in retention of 1-carbon groups in the folate cycle at the expense of transfer to the methylation cycle. Carbon 148-154 methylenetetrahydrofolate reductase Mus musculus 108-113 31525435-0 2019 One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice. Carbon 4-10 methylenetetrahydrofolate reductase Mus musculus 81-86 31525435-3 2019 Deficiencies in one-carbon metabolism, including in methyltetrahydrofolate reductase (MTHFR), have been linked to increased risk of stroke. Carbon 20-26 methylenetetrahydrofolate reductase Mus musculus 52-84 31525435-3 2019 Deficiencies in one-carbon metabolism, including in methyltetrahydrofolate reductase (MTHFR), have been linked to increased risk of stroke. Carbon 20-26 methylenetetrahydrofolate reductase Mus musculus 86-91 31133774-2 2019 One gene associated with increased risk for ASD is methylenetetrahydrofolate-reductase (MTHFR), which encodes a key enzyme in one carbon (C1) metabolism. Carbon 130-136 methylenetetrahydrofolate reductase Mus musculus 51-86 31133774-2 2019 One gene associated with increased risk for ASD is methylenetetrahydrofolate-reductase (MTHFR), which encodes a key enzyme in one carbon (C1) metabolism. Carbon 130-136 methylenetetrahydrofolate reductase Mus musculus 88-93 29329322-9 2018 MEASUREMENTS AND MAIN RESULTS: Loss of Mthfr alters single carbon metabolite levels in the lung and serum including elevated homocysteine and cystathionine and reduced methionine. Carbon 59-65 methylenetetrahydrofolate reductase Mus musculus 39-44 30726997-4 2019 Within one-carbon metabolism, methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Carbon 11-17 methylenetetrahydrofolate reductase Mus musculus 30-65 30726997-4 2019 Within one-carbon metabolism, methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Carbon 11-17 methylenetetrahydrofolate reductase Mus musculus 67-72 30552741-3 2019 Among the genes associated with the increased risk for autism is the methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, which impairs one-carbon (C1) metabolic pathway efficiency. Carbon 155-161 methylenetetrahydrofolate reductase Mus musculus 69-104 30552741-3 2019 Among the genes associated with the increased risk for autism is the methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, which impairs one-carbon (C1) metabolic pathway efficiency. Carbon 155-161 methylenetetrahydrofolate reductase Mus musculus 106-111