PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10570018-0	1999	Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs.	azelastine	0-10	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	57-63	
11948533-3	2002	Because we previously clarified that azelastine, an antiallergy and antiasthmatic drug, is N-demethylated by CYP1A2, CYP2D6, and CYP3A4 in humans, the reaction was used as a model.	azelastine	37-47	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	117-123	
10570018-3	1999	In microsomes from human B-lymphoblast cells, recombinant cytochrome P-450 (CYP)2D6 and CYP1A1 exhibited higher azelastine N-demethylase activity than did other CYP enzymes.	azelastine	112-122	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	58-83	
10570018-4	1999	On the other hand, recombinant CYP3A4 and CYP1A2 as well as CYP1A1 and CYP2D6 in microsomes from baculovirus-infected insect cells were active in azelastine N-demethylation.	azelastine	146-156	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	71-77	
10570018-12	1999	Summarizing the results, azelastine N-demethylation in humans liver microsomes is catalyzed mainly by CYP3A4 and CYP2D6, and CYP1A2 to a small extent (in average, 76.6, 21.8, and 3.9%, respectively), although the percent contribution of each isoform varied among individuals.	azelastine	25-35	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	113-119	
10383922-12	1999	Among the human CYPs tested, the inhibitory effects of azelastine and its two metabolites were the most potent on human CYP2D6.	azelastine	55-65	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	120-126	
9506001-7	1997	Azelastine did not inhibit CYP3A4 activity but it did inhibit CYP2D6 and CYP2C19 activity with Ki values exceeding maximum plasma concentration by 120 to 800-fold.	azelastine	0-10	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	62-68	
10421623-8	1999	These observations suggested that the N-demethylation of azelastine is most extensively catalyzed by the CYP2D6 and 3A4 isoforms in humans.	azelastine	57-67	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	105-111