PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2480337-2 1989 The 50% inhibitory concentrations (IC50) of the agent were approximately 1.0 x 10(-5) M. In addition, azelastine significantly inhibited also 5-lipoxygenase activity in peritoneal cells with an IC50 of 1.0 x 10(-5) M, but not on LTC4 synthetase, LTA4 hydrolase or phospholipase A2 activity. azelastine 102-112 arachidonate 5-lipoxygenase Homo sapiens 142-156 7759463-9 1995 This profile suggests that azelastine may be a novel inhibitor of Ca(2+)-dependent translocation of 5-lipoxygenase from cytosol to the nuclear envelope or a FLAP inhibitor rather than a direct 5-LO inhibitor. azelastine 27-37 arachidonate 5-lipoxygenase Homo sapiens 100-114