PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10421623-4 1999 In microsomes from baculovirus-infected insect cells, recombinant CYP3A4, 2D6, 1A2, and 2C19 exhibited high azelastine N-demethylase activity. azelastine 108-118 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 66-72 11948533-3 2002 Because we previously clarified that azelastine, an antiallergy and antiasthmatic drug, is N-demethylated by CYP1A2, CYP2D6, and CYP3A4 in humans, the reaction was used as a model. azelastine 37-47 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 129-135 10570018-4 1999 On the other hand, recombinant CYP3A4 and CYP1A2 as well as CYP1A1 and CYP2D6 in microsomes from baculovirus-infected insect cells were active in azelastine N-demethylation. azelastine 146-156 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 31-37 10570018-12 1999 Summarizing the results, azelastine N-demethylation in humans liver microsomes is catalyzed mainly by CYP3A4 and CYP2D6, and CYP1A2 to a small extent (in average, 76.6, 21.8, and 3.9%, respectively), although the percent contribution of each isoform varied among individuals. azelastine 25-35 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 102-108 9506001-1 1997 Azelastine, an antihistamine with additional pharmacologic properties, was evaluated for a possible influence on pharmacokinetic and electrocardiographic parameters due to its coadministration with CYP3A4 inhibitor ketoconazole (200 mg every 12 hrs). azelastine 0-10 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 198-204 9506001-8 1997 Therefore, in vitro tests and the absence of electrocardiographic effects suggests azelastine can be safely administered with CYP3A4 inhibitors. azelastine 83-93 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 126-132 10383922-8 1999 Azelastine and desmethylazelastine competitively inhibited CYP3A4 activity (Ki = 23. azelastine 0-10 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 59-65 10383922-14 1999 The inhibition of CYP2C9, CYP2C19, and CYP3A4 activity by azelastine and its two metabolites might be clinically insignificant. azelastine 58-68 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 39-45