PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25549589-0 2015 Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-beta1 Induction of Lung Myofibroblasts. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 77-86 25943094-0 2015 Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-beta1. Hyaluronic Acid 11-21 transforming growth factor beta 1 Homo sapiens 109-118 26005723-2 2015 Hyaluronan (HA) has been shown to induce EMT through either TGF-beta1 or EGF signaling and to be a regulator of the crosstalk between these two pathways in fibroblasts. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 60-69 26005723-2 2015 Hyaluronan (HA) has been shown to induce EMT through either TGF-beta1 or EGF signaling and to be a regulator of the crosstalk between these two pathways in fibroblasts. Hyaluronic Acid 12-14 transforming growth factor beta 1 Homo sapiens 60-69 25804871-4 2015 Shear-thinning, injectable hyaluronic acid (HA) hydrogels were formed through supramolecular guest-host interactions and used to contain IL-10, anti-TGFbeta, or both molecules together. Hyaluronic Acid 44-46 transforming growth factor beta 1 Homo sapiens 149-156 25716319-1 2015 Hyaluronan (HA) promotes transforming growth factor (TGF)-beta1-driven myofibroblast phenotype. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 25-63 25549589-1 2015 The contribution of hyaluronan-dependent pericellular matrix to TGF-beta1-driven induction and maintenance of myofibroblasts is not understood. Hyaluronic Acid 20-30 transforming growth factor beta 1 Homo sapiens 64-73 25549589-8 2015 Inhibition of hyaluronan synthesis in TGF-beta1-induced lung myofibroblasts over a 4day period with 4-methyl umbelliferone (4-MU) further enhanced myofibroblast morphology, caused increased deposition of fibronectin and type I collagen in the ECM, and increased expression of alpha-smooth muscle actin and hyaluronan synthase 2 (HAS2) mRNA. Hyaluronic Acid 14-24 transforming growth factor beta 1 Homo sapiens 38-47 22734649-0 2012 Response of fibroblasts to transforming growth factor-beta1 on two-dimensional and in three-dimensional hyaluronan hydrogels. Hyaluronic Acid 104-114 transforming growth factor beta 1 Homo sapiens 27-59 24099991-6 2014 However, a large hyaluronan coat was seen in cells grown in 20 mM glucose and 1 mM glucosamine, or treated with IL-1beta, TNF-alpha, or TGF-beta. Hyaluronic Acid 17-27 transforming growth factor beta 1 Homo sapiens 136-144 23602877-0 2013 Artificial extracellular matrix composed of collagen I and highly sulfated hyaluronan interferes with TGFbeta(1) signaling and prevents TGFbeta(1)-induced myofibroblast differentiation. Hyaluronic Acid 75-85 transforming growth factor beta 1 Homo sapiens 102-109 23602877-0 2013 Artificial extracellular matrix composed of collagen I and highly sulfated hyaluronan interferes with TGFbeta(1) signaling and prevents TGFbeta(1)-induced myofibroblast differentiation. Hyaluronic Acid 75-85 transforming growth factor beta 1 Homo sapiens 136-143 23589287-3 2013 Our previous studies show that fibroblast differentiation in response to TGF-beta1 is dependent on and mediated by the linear polysaccharide hyaluronan (HA). Hyaluronic Acid 153-155 transforming growth factor beta 1 Homo sapiens 73-82 23589287-0 2013 Transforming growth factor-beta1 (TGF-beta1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Hyaluronic Acid 115-125 transforming growth factor beta 1 Homo sapiens 0-32 23589287-0 2013 Transforming growth factor-beta1 (TGF-beta1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Hyaluronic Acid 115-125 transforming growth factor beta 1 Homo sapiens 34-43 23589287-0 2013 Transforming growth factor-beta1 (TGF-beta1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Hyaluronic Acid 127-129 transforming growth factor beta 1 Homo sapiens 0-32 23589287-0 2013 Transforming growth factor-beta1 (TGF-beta1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Hyaluronic Acid 127-129 transforming growth factor beta 1 Homo sapiens 34-43 23589287-3 2013 Our previous studies show that fibroblast differentiation in response to TGF-beta1 is dependent on and mediated by the linear polysaccharide hyaluronan (HA). Hyaluronic Acid 141-151 transforming growth factor beta 1 Homo sapiens 73-82 23295467-7 2013 RESULTS: 20(OH)D(3) and 20,23(OH)(2)D(3) inhibited TGF-beta1-induced collagen and hyaluronan synthesis similarly to 1,25(OH)(2)D(3) in cultured human fibroblasts. Hyaluronic Acid 82-92 transforming growth factor beta 1 Homo sapiens 51-60 22426137-0 2012 Sulfated hyaluronan and chondroitin sulfate derivatives interact differently with human transforming growth factor-beta1 (TGF-beta1). Hyaluronic Acid 9-19 transforming growth factor beta 1 Homo sapiens 88-120 22426137-0 2012 Sulfated hyaluronan and chondroitin sulfate derivatives interact differently with human transforming growth factor-beta1 (TGF-beta1). Hyaluronic Acid 9-19 transforming growth factor beta 1 Homo sapiens 122-131 22426137-1 2012 This study demonstrates that the modification of hyaluronan (hyaluronic acid; Hya) and chondroitin sulfate (CS) with sulfate groups leads to different binding affinities for recombinant human transforming growth factor-beta1 (TGF-beta1) for comparable average degrees of sulfation (DS). Hyaluronic Acid 49-59 transforming growth factor beta 1 Homo sapiens 192-224 22426137-1 2012 This study demonstrates that the modification of hyaluronan (hyaluronic acid; Hya) and chondroitin sulfate (CS) with sulfate groups leads to different binding affinities for recombinant human transforming growth factor-beta1 (TGF-beta1) for comparable average degrees of sulfation (DS). Hyaluronic Acid 49-59 transforming growth factor beta 1 Homo sapiens 226-235 22426137-1 2012 This study demonstrates that the modification of hyaluronan (hyaluronic acid; Hya) and chondroitin sulfate (CS) with sulfate groups leads to different binding affinities for recombinant human transforming growth factor-beta1 (TGF-beta1) for comparable average degrees of sulfation (DS). Hyaluronic Acid 61-76 transforming growth factor beta 1 Homo sapiens 192-224 22426137-1 2012 This study demonstrates that the modification of hyaluronan (hyaluronic acid; Hya) and chondroitin sulfate (CS) with sulfate groups leads to different binding affinities for recombinant human transforming growth factor-beta1 (TGF-beta1) for comparable average degrees of sulfation (DS). Hyaluronic Acid 61-76 transforming growth factor beta 1 Homo sapiens 226-235 19890996-0 2010 Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro. Hyaluronic Acid 0-15 transforming growth factor beta 1 Homo sapiens 85-117 22061106-6 2012 Adsorption of TGF-beta1 to the aECM and release from the aECM was dependent on the degree of sulfation of hyaluronan. Hyaluronic Acid 106-116 transforming growth factor beta 1 Homo sapiens 14-23 22061106-9 2012 The results indicate that sulfated hyaluronan-containing aECM have the potential to control both the adsorption and release of TGF-beta1, and thereby promote collagen synthesis of hMSC. Hyaluronic Acid 35-45 transforming growth factor beta 1 Homo sapiens 127-136 19890996-0 2010 Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro. Hyaluronic Acid 0-15 transforming growth factor beta 1 Homo sapiens 119-128 19890996-8 2010 We suggested that the profile of CTGF, TGF-beta1, and VEGF gene expressions in our study might provide the rational mechanism for the therapeutic effect of hyaluronan on OA knees. Hyaluronic Acid 156-166 transforming growth factor beta 1 Homo sapiens 39-48 21454519-0 2011 Hyaluronan facilitates transforming growth factor-beta1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 23-55 21454519-4 2011 Hyaluronan (HA) was directly linked to this TGF-beta1-dependent response. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 44-53 21454519-4 2011 Hyaluronan (HA) was directly linked to this TGF-beta1-dependent response. Hyaluronic Acid 12-14 transforming growth factor beta 1 Homo sapiens 44-53 21203839-0 2011 Transforming growth factor-beta 1 in adipose derived stem cells conditioned medium is a dominant paracrine mediator determines hyaluronic acid and collagen expression profile. Hyaluronic Acid 127-142 transforming growth factor beta 1 Homo sapiens 0-33 21203839-9 2011 The fact that TGF-beta1 contained in ADSC-CM not only accelerates collagen deposition but also increase hyaluronic acid synthesis of HDFs through HAS-1 and HAS-2 expression was also elucidated in this study. Hyaluronic Acid 104-119 transforming growth factor beta 1 Homo sapiens 14-23 20685654-0 2010 Hyaluronan synthesis mediates the fibrotic response of keratocytes to transforming growth factor beta. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 70-101 19541937-0 2009 Modulation of TGFbeta1-dependent myofibroblast differentiation by hyaluronan. Hyaluronic Acid 66-76 transforming growth factor beta 1 Homo sapiens 14-22 19808648-1 2009 We have previously demonstrated that transforming growth factor-beta1 (TGF-beta1)-mediated fibroblast-myofibroblast differentiation is associated with accumulation of a hyaluronan (HA) pericellular coat. Hyaluronic Acid 169-179 transforming growth factor beta 1 Homo sapiens 37-69 19808648-1 2009 We have previously demonstrated that transforming growth factor-beta1 (TGF-beta1)-mediated fibroblast-myofibroblast differentiation is associated with accumulation of a hyaluronan (HA) pericellular coat. Hyaluronic Acid 169-179 transforming growth factor beta 1 Homo sapiens 71-80 19541937-5 2009 Transforming growth factor beta(1)-dependent differentiation to the myofibroblastic phenotype was antagonized by the inhibition of hyaluronan synthesis, confirming that hyaluronan was necessary for differentiation. Hyaluronic Acid 131-141 transforming growth factor beta 1 Homo sapiens 0-34 19541937-5 2009 Transforming growth factor beta(1)-dependent differentiation to the myofibroblastic phenotype was antagonized by the inhibition of hyaluronan synthesis, confirming that hyaluronan was necessary for differentiation. Hyaluronic Acid 169-179 transforming growth factor beta 1 Homo sapiens 0-34 16820603-10 2006 CONCLUSIONS: There was overexpression of TGF-beta in MFS associated with altered hyaluronan synthesis, increased apoptosis, impaired progenitor cell recruitment, and abnormal directional migration. Hyaluronic Acid 81-91 transforming growth factor beta 1 Homo sapiens 41-49 18174158-0 2008 Hyaluronan facilitates transforming growth factor-beta1-mediated fibroblast proliferation. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 23-55 19234339-8 2009 TGF-beta(1) induced HAS expression and hyaluronan production. Hyaluronic Acid 39-49 transforming growth factor beta 1 Homo sapiens 0-10 8912726-0 1996 Differential effects of TGF-beta1 on hyaluronan synthesis by fetal and adult skin fibroblasts: implications for cell migration and wound healing. Hyaluronic Acid 37-47 transforming growth factor beta 1 Homo sapiens 24-33 15084590-0 2004 Hyaluronan regulates transforming growth factor-beta1 receptor compartmentalization. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 21-53 15084590-3 2004 In the current study we examined the potential mechanism by which the interaction between hyaluronan (HA) and CD44 regulates TGF-beta receptor function. Hyaluronic Acid 90-100 transforming growth factor beta 1 Homo sapiens 125-133 15084590-3 2004 In the current study we examined the potential mechanism by which the interaction between hyaluronan (HA) and CD44 regulates TGF-beta receptor function. Hyaluronic Acid 102-104 transforming growth factor beta 1 Homo sapiens 125-133 15161634-0 2004 Hyaluronan attenuates transforming growth factor-beta1-mediated signaling in renal proximal tubular epithelial cells. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 22-54 14706828-6 2004 In this study, we demonstrate that oncostatin M and transforming growth factor beta1 (TGF-beta1) which stimulate hyaluronan binding to HTB58 lung epithelial-derived tumor cells, also induce the release of soluble CD44. Hyaluronic Acid 113-123 transforming growth factor beta 1 Homo sapiens 86-95 14706828-8 2004 In contrast, soluble CD44 released from TGF-beta1-treated HTB58 cells differed in its hyaluronan-binding capacity from cell surface CD44 expressed on TGF-beta1-stimulated cells. Hyaluronic Acid 86-96 transforming growth factor beta 1 Homo sapiens 40-49 12023510-8 2002 Hypoxia enhanced the effect of all TGF-beta isoforms, particularly that of TGF-beta3, on the secretion of hyaluronic acid and chondroitin and dermatan sulfates. Hyaluronic Acid 106-121 transforming growth factor beta 1 Homo sapiens 35-43 9665020-7 1998 Hyaluronic acid, fibronectin receptor, and TGF-beta levels also increased in patients with acute steroid-resistant rejection; hyaluronic acid: 290 +/- 10.8 micrograms/l vs 154 +/- 13.6 micrograms/l and 131 +/- 11.7 micrograms/l in patients with steroid-sensitive and no rejection, respectively; fibronectin receptor: 1003 +/- 23.5 ng/ml vs 573 +/- 24.8 ng/ml and 428 +/- 13.6 ng/ ml in patients with steroid-sensitive and no rejection, respectively; and TGF-beta: 393 +/- 14.9 pg/ml versus 315 +/- 10.7 pg/ml and 233 +/- 8.9 pg/ml in patients with steroid-sensitive and no rejection, respectively. Hyaluronic Acid 126-141 transforming growth factor beta 1 Homo sapiens 43-51 16540432-0 2006 Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells. Hyaluronic Acid 108-118 transforming growth factor beta 1 Homo sapiens 0-31 15770661-0 2005 TGF-beta induced hyaluronan synthesis in orbital fibroblasts involves protein kinase C betaII activation in vitro. Hyaluronic Acid 17-27 transforming growth factor beta 1 Homo sapiens 0-8 11869079-10 2002 RESULTS: Exogenous TGF-beta1 increased the accumulation of aggrecan and hyaluronan in the CAM of chondrocytes and down-regulated the intracellular levels of MMP-1 and -3. Hyaluronic Acid 72-82 transforming growth factor beta 1 Homo sapiens 19-28 11453237-9 2001 Collagen and hyaluronic acid increased secretion of TGF-beta1, a growth factor involved in bone remodeling. Hyaluronic Acid 13-28 transforming growth factor beta 1 Homo sapiens 52-61 11215744-4 2000 Correlation analyses for TGF-beta and IL-6 indicated a strong dependence of the production of hyaluronan on cytokine levels and, to a lesser extent, on IL-1beta levels. Hyaluronic Acid 94-104 transforming growth factor beta 1 Homo sapiens 25-33 11017908-0 2000 Activation and transforming growth factor-beta production in eosinophils by hyaluronan. Hyaluronic Acid 76-86 transforming growth factor beta 1 Homo sapiens 15-46 9893571-0 1998 Hyaluronan production in human rheumatoid fibroblastic synovial lining cells is increased by interleukin 1 beta but inhibited by transforming growth factor beta 1. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 129-162 9622588-2 1998 The TGF-beta1 treatment stimulated productions of hyaluronic acid and laminin, and significantly decreased the secretion of hepatocyte growth factor in LI90 cells. Hyaluronic Acid 50-65 transforming growth factor beta 1 Homo sapiens 4-13 9466580-9 1998 Versican and hyaluronan are enriched in the extracellular matrix adjacent to both PDGF- and TGF-beta1-positive cells. Hyaluronic Acid 13-23 transforming growth factor beta 1 Homo sapiens 92-101 9106158-3 1997 Hyaluronan production increased in cells treated with TGF-beta, PDGF-AA and PDGF-BB. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 54-62 8863330-1 1996 OBJECTIVE: To assess effects of the inflammatory cytokines (IL-1-beta, TNF-alpha, TGF-beta 1) and dialysate effluent on synthesis of hyaluronic acid by human peritoneal mesothelial cells (HMC) in in vitro culture. Hyaluronic Acid 133-148 transforming growth factor beta 1 Homo sapiens 82-92 2226352-10 1990 In the medium fraction, TGF-beta increased the proportion of hyaluronic acid, chondroitin sulfate and dermatan sulfate released. Hyaluronic Acid 61-76 transforming growth factor beta 1 Homo sapiens 24-32 7748222-0 1995 Transforming growth factor beta 1, a major stimulator of hyaluronan synthesis in human synovial lining cells. Hyaluronic Acid 57-67 transforming growth factor beta 1 Homo sapiens 0-33 7748222-6 1995 RESULTS: Hyaluronan synthesis was stimulated in synovial lining cells by transforming growth factor beta 1 (TGF beta 1), interleukin-1 beta (IL-1 beta), and to a lesser extent by tumor necrosis factor alpha (TNF alpha). Hyaluronic Acid 9-19 transforming growth factor beta 1 Homo sapiens 73-106 7748222-6 1995 RESULTS: Hyaluronan synthesis was stimulated in synovial lining cells by transforming growth factor beta 1 (TGF beta 1), interleukin-1 beta (IL-1 beta), and to a lesser extent by tumor necrosis factor alpha (TNF alpha). Hyaluronic Acid 9-19 transforming growth factor beta 1 Homo sapiens 108-118 7748222-7 1995 Analysis of the molecular weight distribution of hyaluronan after stimulation of synovial lining cells with TGF beta 1, IL-1 beta, and TNF alpha indicated that hyaluronan is synthesized in a high molecular weight form and might be degraded in the course of inflammatory processes by oxygen-derived free radicals. Hyaluronic Acid 49-59 transforming growth factor beta 1 Homo sapiens 108-118 7748222-7 1995 Analysis of the molecular weight distribution of hyaluronan after stimulation of synovial lining cells with TGF beta 1, IL-1 beta, and TNF alpha indicated that hyaluronan is synthesized in a high molecular weight form and might be degraded in the course of inflammatory processes by oxygen-derived free radicals. Hyaluronic Acid 160-170 transforming growth factor beta 1 Homo sapiens 108-118 7748222-8 1995 CONCLUSION: Our findings suggest that TGF beta 1 is a major stimulator of hyaluronan synthesis in human synovial lining cells and might be involved in the pathogenic mechanisms of joint swelling in inflammatory and degenerative joint diseases. Hyaluronic Acid 74-84 transforming growth factor beta 1 Homo sapiens 38-48 8619927-0 1995 The interdependent modulation of hyaluronan synthesis by TGF-beta 1 and extracellular matrix: consequences for the control of cell migration. Hyaluronic Acid 33-43 transforming growth factor beta 1 Homo sapiens 57-67 8619927-1 1995 The principal objective of this communication has been to determine the manner in which two tissue culture substrata (plastic dishes and type I collagen gels) modulate the response of adult skin fibroblasts to TGF-beta 1 with respect to hyaluronan (HA) synthesis. Hyaluronic Acid 237-247 transforming growth factor beta 1 Homo sapiens 210-220 1506427-0 1992 Antagonistic effects of TGF-beta 1 and MSF on fibroblast migration and hyaluronic acid synthesis. Hyaluronic Acid 71-86 transforming growth factor beta 1 Homo sapiens 24-34 34058990-0 2021 CircHYBID regulates hyaluronan metabolism in chondrocytes via hsa-miR-29b-3p/TGF-beta1 axis. Hyaluronic Acid 20-30 transforming growth factor beta 1 Homo sapiens 77-86 35055112-0 2022 Tethered TGF-beta1 in a Hyaluronic Acid-Based Bioink for Bioprinting Cartilaginous Tissues. Hyaluronic Acid 24-39 transforming growth factor beta 1 Homo sapiens 9-18 35055112-4 2022 Therefore, in this study, we established a dual-stage crosslinked hyaluronic acid-based bioink that enabled covalent tethering of transforming growth factor-beta 1 (TGF-beta1). Hyaluronic Acid 66-81 transforming growth factor beta 1 Homo sapiens 130-163 35055112-4 2022 Therefore, in this study, we established a dual-stage crosslinked hyaluronic acid-based bioink that enabled covalent tethering of transforming growth factor-beta 1 (TGF-beta1). Hyaluronic Acid 66-81 transforming growth factor beta 1 Homo sapiens 165-174 2298235-0 1990 TGF-beta enhances the production of hyaluronan in human lung but not in skin fibroblasts. Hyaluronic Acid 36-46 transforming growth factor beta 1 Homo sapiens 0-8 2298235-5 1990 TGF-beta induced a three- to fourfold increase in hyaluronan production by lung cells but had no effect on skin fibroblasts. Hyaluronic Acid 50-60 transforming growth factor beta 1 Homo sapiens 0-8 2298235-8 1990 The ED50 for TGF-beta on hyaluronan accumulation in lung cells was the same as that for proteoglycan accumulation, i.e., 40 pM. Hyaluronic Acid 25-35 transforming growth factor beta 1 Homo sapiens 13-21 2298235-10 1990 The induction time needed to attain full effect of TGF-beta was 6 h for both hyaluronan and proteoglycan synthesis. Hyaluronic Acid 77-87 transforming growth factor beta 1 Homo sapiens 51-59 35514434-3 2022 We hypothesized that excess TGF-beta1 can be removed from aqueous humor through the addition of oxidized hyaluronic acid (O-HA) hydrogels that are seeded with decorin (O-HA + D). Hyaluronic Acid 105-120 transforming growth factor beta 1 Homo sapiens 28-37 31326566-0 2019 Hyaluronic acid promotes osteogenic differentiation of human amniotic mesenchymal stem cells via the TGF-beta/Smad signalling pathway. Hyaluronic Acid 0-15 transforming growth factor beta 1 Homo sapiens 101-109 31630264-7 2020 RESULTS: The expression levels of TGFbeta1 and COL1A1 mRNA were decreased in the cross-linked hyaluronic acid gel-treated group, and the protein expression of levels TGFbeta1 and COL1A1 were also reduced, as detected by Western blotting in vitro and in vivo (P < 0.05). Hyaluronic Acid 94-109 transforming growth factor beta 1 Homo sapiens 34-42 31630264-7 2020 RESULTS: The expression levels of TGFbeta1 and COL1A1 mRNA were decreased in the cross-linked hyaluronic acid gel-treated group, and the protein expression of levels TGFbeta1 and COL1A1 were also reduced, as detected by Western blotting in vitro and in vivo (P < 0.05). Hyaluronic Acid 94-109 transforming growth factor beta 1 Homo sapiens 166-174 31630264-11 2020 CONCLUSIONS: These results indicate that cross-linked hyaluronic acid gel can prevent epidural adhesion by inhibiting inflammatory factors, such as IL-6, and downregulating TGFbeta1 and COL1A1 mRNA expression. Hyaluronic Acid 54-69 transforming growth factor beta 1 Homo sapiens 173-181 31536840-0 2019 An injectable heparin-conjugated hyaluronan scaffold for local delivery of Transforming Growth Factor beta1 promotes successful chondrogenesis. Hyaluronic Acid 33-43 transforming growth factor beta 1 Homo sapiens 75-107 31536840-6 2019 We show that heparin, a GAG known to bind a wide range of GFs, covalently conjugated to a hyaluronan hydrogel, leads to a sustained release of TGF-beta1. Hyaluronic Acid 90-100 transforming growth factor beta 1 Homo sapiens 143-152 31536840-7 2019 Using this heparin-conjugated hyaluronan hydrogel, 0.25 to 50 ng TGF-beta1 per scaffold was loaded and cell viability, proliferation and cartilaginous matrix deposition of the encapsulated chondroprogenitor cells were measured. Hyaluronic Acid 30-40 transforming growth factor beta 1 Homo sapiens 65-74 31536840-13 2019 Here we show development of an injectable hyaluronan hydrogel, which achieves a sustained release of TGF-beta1 due to covalent conjugation of heparin. Hyaluronic Acid 42-52 transforming growth factor beta 1 Homo sapiens 101-110 31437481-0 2019 TGF-beta1 promotes hyaluronan synthesis by upregulating hyaluronan synthase 2 expression in human granulosa-lutein cells. Hyaluronic Acid 19-29 transforming growth factor beta 1 Homo sapiens 0-9 31437481-3 2019 Previous studies have shown the imperative role for TGF-beta signaling in the regulation of hyaluronan-mediated cumulus expansion and ovulation in human granulosa-lutein (hGL) cells. Hyaluronic Acid 92-102 transforming growth factor beta 1 Homo sapiens 52-60 31437481-4 2019 However, the detailed underlying molecular mechanisms by which TGF-beta regulates the synthesis of hyaluronan in hGL cells are not fully elucidated. Hyaluronic Acid 99-109 transforming growth factor beta 1 Homo sapiens 63-71 31437481-5 2019 Using both primary and immortalized hGL cells as study models, we provide the first data showing that TGF-beta1 significantly promoted the synthesis of hyaluronan by upregulating the expression of hyaluronan synthase 2 in these cells. Hyaluronic Acid 152-162 transforming growth factor beta 1 Homo sapiens 102-111 31437481-8 2019 Notably, we showed that SNAIL transcription factor is a critical molecule mediating the TGF-beta signaling, which contributes to the increase in hyaluronan synthesis. Hyaluronic Acid 145-155 transforming growth factor beta 1 Homo sapiens 88-96 31437481-9 2019 These results of our in vitro studies suggest that intraovarian TGF-beta1 plays a functional role in the local regulation of hyaluronan synthesis in hGL cells. Hyaluronic Acid 125-135 transforming growth factor beta 1 Homo sapiens 64-73 31127393-0 2019 Hyaluronan/collagen hydrogel matrices containing high-sulfated hyaluronan microgels for regulating transforming growth factor-beta1. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 99-131 31361756-0 2019 Recombinant human PRG4 (rhPRG4) suppresses breast cancer cell invasion by inhibiting TGFbeta-Hyaluronan-CD44 signalling pathway. Hyaluronic Acid 93-103 transforming growth factor beta 1 Homo sapiens 85-92 31361756-6 2019 In mechanistic studies, we find that rhPRG4 suppresses TGFbeta-induced invasiveness of cancer cells by inhibiting the downstream hyaluronan (HA)-cell surface cluster of differentiation 44 (CD44) signalling axis. Hyaluronic Acid 129-139 transforming growth factor beta 1 Homo sapiens 55-62 31361756-6 2019 In mechanistic studies, we find that rhPRG4 suppresses TGFbeta-induced invasiveness of cancer cells by inhibiting the downstream hyaluronan (HA)-cell surface cluster of differentiation 44 (CD44) signalling axis. Hyaluronic Acid 141-143 transforming growth factor beta 1 Homo sapiens 55-62 31127393-0 2019 Hyaluronan/collagen hydrogel matrices containing high-sulfated hyaluronan microgels for regulating transforming growth factor-beta1. Hyaluronic Acid 63-73 transforming growth factor beta 1 Homo sapiens 99-131 31210802-0 2019 Low Degree Hyaluronic Acid Crosslinking Inducing the Release of TGF-Beta1 in Conditioned Medium of Wharton"s Jelly-Derived Stem Cells. Hyaluronic Acid 11-26 transforming growth factor beta 1 Homo sapiens 64-73 30453642-0 2018 Chitosan-Polylactide/Hyaluronic Acid Complex Microspheres as Carriers for Controlled Release of Bioactive Transforming Growth Factor-beta1. Hyaluronic Acid 21-36 transforming growth factor beta 1 Homo sapiens 106-138 31187872-12 2019 Hyaluronic acid serum level was positively and iron concentration was negatively associated with TGF-b1 ex-pression in the selected consecutive liver compartments. Hyaluronic Acid 0-15 transforming growth factor beta 1 Homo sapiens 97-103 30947333-1 2019 Purpose: Hyaluronan (HA) is a potential regulator of TGFbeta1-induced differentiation in perimysial orbital fibroblasts (pOFs). Hyaluronic Acid 9-19 transforming growth factor beta 1 Homo sapiens 53-61 29898378-0 2018 cAMP attenuates TGF-beta"s profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4. Hyaluronic Acid 96-106 transforming growth factor beta 1 Homo sapiens 16-24 29782701-0 2018 TGF-beta1-Modified Hyaluronic Acid/Poly(glycidol) Hydrogels for Chondrogenic Differentiation of Human Mesenchymal Stromal Cells. Hyaluronic Acid 19-34 transforming growth factor beta 1 Homo sapiens 0-9 29566045-0 2018 TGF-beta1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels. Hyaluronic Acid 96-111 transforming growth factor beta 1 Homo sapiens 0-9 28446792-0 2017 Sulfated Hyaluronan Derivatives Modulate TGF-beta1:Receptor Complex Formation: Possible Consequences for TGF-beta1 Signaling. Hyaluronic Acid 9-19 transforming growth factor beta 1 Homo sapiens 41-50 28446792-0 2017 Sulfated Hyaluronan Derivatives Modulate TGF-beta1:Receptor Complex Formation: Possible Consequences for TGF-beta1 Signaling. Hyaluronic Acid 9-19 transforming growth factor beta 1 Homo sapiens 105-114 30032656-0 2018 Hyaluronan antagonizes the differentiation effect of TGF-beta1 on nasal epithelial cells through down-regulation of TGF-beta type I receptor. Hyaluronic Acid 0-10 transforming growth factor beta 1 Homo sapiens 53-62