PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9786890-0 1998 Hyaluronan bound to CD44 on keratinocytes is displaced by hyaluronan decasaccharides and not hexasaccharides. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Rattus norvegicus 20-24 9786890-5 1998 The hyaluronan in the patches is bound to CD44 as indicated by co-localization with an antibody to CD44, and by displacement with hyaluronan decasaccharides as well as with an antibody that blocks hyaluronan binding to CD44. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Rattus norvegicus 42-46 9786890-5 1998 The hyaluronan in the patches is bound to CD44 as indicated by co-localization with an antibody to CD44, and by displacement with hyaluronan decasaccharides as well as with an antibody that blocks hyaluronan binding to CD44. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Rattus norvegicus 99-103 9786890-5 1998 The hyaluronan in the patches is bound to CD44 as indicated by co-localization with an antibody to CD44, and by displacement with hyaluronan decasaccharides as well as with an antibody that blocks hyaluronan binding to CD44. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Rattus norvegicus 99-103 9786890-5 1998 The hyaluronan in the patches is bound to CD44 as indicated by co-localization with an antibody to CD44, and by displacement with hyaluronan decasaccharides as well as with an antibody that blocks hyaluronan binding to CD44. Hyaluronic Acid 130-140 CD44 molecule (Indian blood group) Rattus norvegicus 42-46 9565080-3 1998 Cell surface hyaluronan-binding proteins such as CD44 are presumed to be important in the cellular interactions with hyaluronan in both of these processes. Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Rattus norvegicus 49-53 9565080-7 1998 These findings suggest that the CD44s isoform has a role in the development of the diarthrodial joint, presumably through interaction with hyaluronan. Hyaluronic Acid 139-149 CD44 molecule (Indian blood group) Rattus norvegicus 32-36 8829115-8 1996 Immunohistochemistry staining also demonstrated hyaluronan deposition within segmental areas of proliferating CD44+ cells, suggesting a functional interaction between the CD44/hyaluronan receptor-ligand pair during mesangial cell proliferation. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Rattus norvegicus 110-114 9345031-7 1997 However, after attachment, S cells became immunopositive for collagens I, II, III, osteopontin, and also for the cell surface receptor CD44, which mediates cell attachment to hyaluronan and osteopontin. Hyaluronic Acid 175-185 CD44 molecule (Indian blood group) Rattus norvegicus 135-139 9097914-7 1997 Hyaluronan deposition was accompanied by the presence of many CD44+ cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Rattus norvegicus 62-66 9097914-14 1997 In conclusion, CD44 is constitutively expressed in normal kidney and is dramatically up-regulated in rat anti-GBM disease, suggesting possible roles for the CD44-hyaluronan interaction in leucocyte recruitment, renal fibrosis and tubular cell-matrix and cell-cell interactions during the induction and progression of crescentic glomerulonephritis. Hyaluronic Acid 162-172 CD44 molecule (Indian blood group) Rattus norvegicus 15-19 9097914-14 1997 In conclusion, CD44 is constitutively expressed in normal kidney and is dramatically up-regulated in rat anti-GBM disease, suggesting possible roles for the CD44-hyaluronan interaction in leucocyte recruitment, renal fibrosis and tubular cell-matrix and cell-cell interactions during the induction and progression of crescentic glomerulonephritis. Hyaluronic Acid 162-172 CD44 molecule (Indian blood group) Rattus norvegicus 157-161 8922392-0 1996 Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity. Hyaluronic Acid 62-73 CD44 molecule (Indian blood group) Rattus norvegicus 32-36 8829115-8 1996 Immunohistochemistry staining also demonstrated hyaluronan deposition within segmental areas of proliferating CD44+ cells, suggesting a functional interaction between the CD44/hyaluronan receptor-ligand pair during mesangial cell proliferation. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Rattus norvegicus 171-175 8829115-10 1996 In addition, hyaluronan-dependent aggregation of CD44+ mesangial cells was specifically inhibited by an anti-CD44 antibody, demonstrating a functional interaction between hyaluronan and the CD44 expressed on the surface of rat mesangial cells. Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Rattus norvegicus 49-53 8829115-10 1996 In addition, hyaluronan-dependent aggregation of CD44+ mesangial cells was specifically inhibited by an anti-CD44 antibody, demonstrating a functional interaction between hyaluronan and the CD44 expressed on the surface of rat mesangial cells. Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Rattus norvegicus 109-113 8829115-10 1996 In addition, hyaluronan-dependent aggregation of CD44+ mesangial cells was specifically inhibited by an anti-CD44 antibody, demonstrating a functional interaction between hyaluronan and the CD44 expressed on the surface of rat mesangial cells. Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Rattus norvegicus 109-113 8829115-10 1996 In addition, hyaluronan-dependent aggregation of CD44+ mesangial cells was specifically inhibited by an anti-CD44 antibody, demonstrating a functional interaction between hyaluronan and the CD44 expressed on the surface of rat mesangial cells. Hyaluronic Acid 171-181 CD44 molecule (Indian blood group) Rattus norvegicus 49-53 8829115-10 1996 In addition, hyaluronan-dependent aggregation of CD44+ mesangial cells was specifically inhibited by an anti-CD44 antibody, demonstrating a functional interaction between hyaluronan and the CD44 expressed on the surface of rat mesangial cells. Hyaluronic Acid 171-181 CD44 molecule (Indian blood group) Rattus norvegicus 109-113 8829115-10 1996 In addition, hyaluronan-dependent aggregation of CD44+ mesangial cells was specifically inhibited by an anti-CD44 antibody, demonstrating a functional interaction between hyaluronan and the CD44 expressed on the surface of rat mesangial cells. Hyaluronic Acid 171-181 CD44 molecule (Indian blood group) Rattus norvegicus 109-113 8764866-1 1996 CD44 has been described as a cell surface hyaluronan receptor present on a variety of different cells, and it is generally assumed to be prevalent in most connective tissues that contain hyaluronan. Hyaluronic Acid 42-52 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 8609213-1 1996 CD44, the principal receptor for hyaluronic acid, is a widely distributed cell surface proteoglycan involved in cellular activation, proliferation, and migration. Hyaluronic Acid 33-48 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 8609213-7 1996 Through binding to hyaluronic acid, CD44 augmented DNA synthesis in cultured human and rat smooth muscle cells by 48 +/- 7.8 and 100 +/- 12.5%, respectively, an effect inhibited by an anti-CD44 antibody that blocked hyaluronate binding. Hyaluronic Acid 19-34 CD44 molecule (Indian blood group) Rattus norvegicus 189-193 8609213-7 1996 Through binding to hyaluronic acid, CD44 augmented DNA synthesis in cultured human and rat smooth muscle cells by 48 +/- 7.8 and 100 +/- 12.5%, respectively, an effect inhibited by an anti-CD44 antibody that blocked hyaluronate binding. Hyaluronic Acid 216-227 CD44 molecule (Indian blood group) Rattus norvegicus 189-193 8025267-0 1994 CD44 can mediate the adhesion of platelets to hyaluronan. Hyaluronic Acid 46-56 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 7542251-0 1995 Monoclonal antibodies to CD44 and their influence on hyaluronan recognition. Hyaluronic Acid 53-63 CD44 molecule (Indian blood group) Rattus norvegicus 25-29 7540113-1 1995 CD44 is a multifunctional adhesion molecule that binds to hyaluronic acid, type I collagen, and fibronectin. Hyaluronic Acid 58-73 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 7544799-6 1995 Keratinocyte adhesion to transfectants expressing variant exons 4-7 was greater than to cells expressing standard CD44 and could be inhibited with hyaluronan or digestion with hyaluronidase. Hyaluronic Acid 147-157 CD44 molecule (Indian blood group) Rattus norvegicus 114-118 8025267-4 1994 This form of CD44 also had the capacity to bind hyaluronan, because detergent extracts of platelets as well as intact platelets could bind soluble [3H]hyaluronan, and this property was blocked by antibodies directed against CD44. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Rattus norvegicus 13-17 8025267-4 1994 This form of CD44 also had the capacity to bind hyaluronan, because detergent extracts of platelets as well as intact platelets could bind soluble [3H]hyaluronan, and this property was blocked by antibodies directed against CD44. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Rattus norvegicus 224-228 8025267-4 1994 This form of CD44 also had the capacity to bind hyaluronan, because detergent extracts of platelets as well as intact platelets could bind soluble [3H]hyaluronan, and this property was blocked by antibodies directed against CD44. Hyaluronic Acid 151-161 CD44 molecule (Indian blood group) Rattus norvegicus 13-17 8025267-4 1994 This form of CD44 also had the capacity to bind hyaluronan, because detergent extracts of platelets as well as intact platelets could bind soluble [3H]hyaluronan, and this property was blocked by antibodies directed against CD44. Hyaluronic Acid 151-161 CD44 molecule (Indian blood group) Rattus norvegicus 224-228 8025267-7 1994 These results suggested that CD44 was responsible for the attachment of platelets to hyaluronan. Hyaluronic Acid 85-95 CD44 molecule (Indian blood group) Rattus norvegicus 29-33 34239300-4 2021 Hence, the study objective was to develop Apa-loaded bovine serum albumin nanoparticles (Apa-BSA-NPs) coated with hyaluronic acid (HA); a natural polymer possessing unique mucoadhesive and viscoelastic features with the capacity to actively target CD44 positive retinal cells, for topical administration in DR. Methods: Apa-BSA-NPs were prepared by desolvation using glutaraldehyde for cross-linking. Hyaluronic Acid 114-129 CD44 molecule (Indian blood group) Rattus norvegicus 248-252 7507229-7 1994 The oncogene-transformed IEC clones display a high degree of hyaluronic acid-dependent cell-cell adhesion that is not observed in the parental IEC-18 cells suggesting that ras- and src-induced overexpression of CD44 can alter the adhesion properties of intestinal cells. Hyaluronic Acid 61-76 CD44 molecule (Indian blood group) Rattus norvegicus 211-215 7680079-4 1993 One such receptor is the glycoprotein, CD44, whose main ligand is hyaluronate. Hyaluronic Acid 66-77 CD44 molecule (Indian blood group) Rattus norvegicus 39-43 7680079-10 1993 RESULTS: Marked accumulation of hyaluronate was demonstrated in developing and sclerosing crescents, in association with local infiltration of T lymphocytes and monocyte/macrophages, cells known to express CD44. Hyaluronic Acid 32-43 CD44 molecule (Indian blood group) Rattus norvegicus 206-210 7680079-12 1993 CONCLUSIONS: Hyaluronate is an abundant extracellular component of crescents, and may play a critical role in their formation, by its effects on migration and activation of CD44+ lymphocytes, monocyte/macrophages, fibroblasts and epithelial cells. Hyaluronic Acid 13-24 CD44 molecule (Indian blood group) Rattus norvegicus 173-177 34239300-4 2021 Hence, the study objective was to develop Apa-loaded bovine serum albumin nanoparticles (Apa-BSA-NPs) coated with hyaluronic acid (HA); a natural polymer possessing unique mucoadhesive and viscoelastic features with the capacity to actively target CD44 positive retinal cells, for topical administration in DR. Methods: Apa-BSA-NPs were prepared by desolvation using glutaraldehyde for cross-linking. Hyaluronic Acid 131-133 CD44 molecule (Indian blood group) Rattus norvegicus 248-252 35516840-9 2022 CD44 protein was observed in some of the bile duct epithelium, around which hyaluronic acid was deposited, and these bile duct lesions were concordant with the area of hepatic fibrosis. Hyaluronic Acid 76-91 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 32924257-0 2021 High molecular weight form of hyaluronic acid reduces neuroinflammatory response in injured sciatic nerve via the intracellular domain of CD44. Hyaluronic Acid 30-45 CD44 molecule (Indian blood group) Rattus norvegicus 138-142 33609543-0 2021 Possible mechanisms for the renoprotective action of adipose-derived mesenchymal stem cells with CD44-targeted hyaluronic acid against renal ischemia. Hyaluronic Acid 111-126 CD44 molecule (Indian blood group) Rattus norvegicus 97-101 33092298-1 2020 Inflammatory bowel diseases (IBDs) are chronic conditions that can benefit from the combined treatment of adenosine receptor agonists and hyaluronic acid (HA), which, binding the CD44, has pro-survival effects. Hyaluronic Acid 138-153 CD44 molecule (Indian blood group) Rattus norvegicus 179-183 33092298-1 2020 Inflammatory bowel diseases (IBDs) are chronic conditions that can benefit from the combined treatment of adenosine receptor agonists and hyaluronic acid (HA), which, binding the CD44, has pro-survival effects. Hyaluronic Acid 155-157 CD44 molecule (Indian blood group) Rattus norvegicus 179-183 32681961-3 2020 Hyaluronic acid (HA), a natural polysaccharide, is a specific ligand for CD44 that is overexpressed on the surface of activated macrophages. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Rattus norvegicus 73-77 32681961-3 2020 Hyaluronic acid (HA), a natural polysaccharide, is a specific ligand for CD44 that is overexpressed on the surface of activated macrophages. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Rattus norvegicus 73-77 28043889-9 2017 In summary, the results of this study show that the activation of hyaluronan synthesis machinery, especially the expression of CD44 is strongly associated with EMT induced by EGF and wounding in mesothelial cells. Hyaluronic Acid 66-76 CD44 molecule (Indian blood group) Rattus norvegicus 127-131 30536088-3 2019 SHs can proliferate to form colonies in serum-free medium on hyaluronic acid-coated dishes, of which cells show CD44 positivity (CD44+ SHs). Hyaluronic Acid 61-76 CD44 molecule (Indian blood group) Rattus norvegicus 112-116 30536088-3 2019 SHs can proliferate to form colonies in serum-free medium on hyaluronic acid-coated dishes, of which cells show CD44 positivity (CD44+ SHs). Hyaluronic Acid 61-76 CD44 molecule (Indian blood group) Rattus norvegicus 129-133 29175954-1 2018 We studied, in male Sprague Dawley rats, the role of the cognate hyaluronan receptor, CD44 signaling in the antihyperalgesia induced by high molecular weight hyaluronan (HMWH). Hyaluronic Acid 65-75 CD44 molecule (Indian blood group) Rattus norvegicus 86-90 29175954-2 2018 Low molecular weight hyaluronan (LMWH) acts at both peptidergic and nonpeptidergic nociceptors to induce mechanical hyperalgesia that is prevented by intrathecal oligodeoxynucleotide antisense to CD44 mRNA, which also prevents hyperalgesia induced by a CD44 receptor agonist, A6. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Rattus norvegicus 196-200 29175954-2 2018 Low molecular weight hyaluronan (LMWH) acts at both peptidergic and nonpeptidergic nociceptors to induce mechanical hyperalgesia that is prevented by intrathecal oligodeoxynucleotide antisense to CD44 mRNA, which also prevents hyperalgesia induced by a CD44 receptor agonist, A6. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Rattus norvegicus 253-257 29175954-8 2018 These results demonstrate the central role of CD44 signaling in HMWH-induced antihyperalgesia, and establish it as a therapeutic target against inflammatory and neuropathic pain.SIGNIFICANCE STATEMENT We demonstrate that hyaluronan (HA) with different molecular weights produces opposing nociceptive effects. Hyaluronic Acid 221-231 CD44 molecule (Indian blood group) Rattus norvegicus 46-50 29175954-8 2018 These results demonstrate the central role of CD44 signaling in HMWH-induced antihyperalgesia, and establish it as a therapeutic target against inflammatory and neuropathic pain.SIGNIFICANCE STATEMENT We demonstrate that hyaluronan (HA) with different molecular weights produces opposing nociceptive effects. Hyaluronic Acid 233-235 CD44 molecule (Indian blood group) Rattus norvegicus 46-50 27018976-2 2016 Hyaluronic acid (HA) through its receptor CD44 has been described to be involved in the process of angiogenesis. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Rattus norvegicus 42-46 28575959-7 2017 Hyaluronic acid (HA) is conjugated as targeting moiety for CD-44 (cancer stem cell marker) to fabricate a complete targeted drug delivery vehicle specific for pancreatic cancer. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Rattus norvegicus 59-64 28575959-7 2017 Hyaluronic acid (HA) is conjugated as targeting moiety for CD-44 (cancer stem cell marker) to fabricate a complete targeted drug delivery vehicle specific for pancreatic cancer. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Rattus norvegicus 59-64 28460475-0 2017 Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling. Hyaluronic Acid 88-98 CD44 molecule (Indian blood group) Rattus norvegicus 99-103 28460475-0 2017 Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling. Hyaluronic Acid 88-98 CD44 molecule (Indian blood group) Rattus norvegicus 104-109 28460475-1 2017 Higher levels of hyaluronan (HA) and its receptors CD44 and RHAMM have been associated with poor prognosis and metastasis in NSCLC. Hyaluronic Acid 17-27 CD44 molecule (Indian blood group) Rattus norvegicus 51-55 28460475-1 2017 Higher levels of hyaluronan (HA) and its receptors CD44 and RHAMM have been associated with poor prognosis and metastasis in NSCLC. Hyaluronic Acid 17-27 CD44 molecule (Indian blood group) Rattus norvegicus 60-65 27085217-0 2016 Angiotensin II AT1 receptor alters ACE2 activity, eNOS expression and CD44-hyaluronan interaction in rats with hypertension and myocardial fibrosis. Hyaluronic Acid 75-85 CD44 molecule (Indian blood group) Rattus norvegicus 70-74 27085217-1 2016 AIM: This study tested the hypothesis that angiotensin II (Ang II) AT1 receptor is involved in development of hypertension and cardiac fibrosis via modifying ACE2 activity, eNOS expression and CD44-hyaluronan interaction. Hyaluronic Acid 198-208 CD44 molecule (Indian blood group) Rattus norvegicus 193-197 27018976-2 2016 Hyaluronic acid (HA) through its receptor CD44 has been described to be involved in the process of angiogenesis. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Rattus norvegicus 42-46 22808265-5 2012 This bioinformatic analysis yielded a network of genes with connectivity biased toward Hnf4alpha (but including Hnf1alpha, hyaluronic acid-CD44, and notch pathways). Hyaluronic Acid 123-138 CD44 molecule (Indian blood group) Rattus norvegicus 139-143 26302663-1 2015 Hyaluronic acid (HA), a nonimmunogenic, biocompatible polymer found in different biological tissues, has the potential to attach to CD44 receptors on the surface of certain cancer cells, where the receptor is overexpressed compared with normal cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Rattus norvegicus 132-136 26302663-1 2015 Hyaluronic acid (HA), a nonimmunogenic, biocompatible polymer found in different biological tissues, has the potential to attach to CD44 receptors on the surface of certain cancer cells, where the receptor is overexpressed compared with normal cells. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Rattus norvegicus 132-136 23680367-0 2013 Hyaluronan-modified core-shell liponanoparticles targeting CD44-positive retinal pigment epithelium cells via intravitreal injection. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Rattus norvegicus 59-63 23280959-4 2013 We demonstrate that a large number of CG4 cells that had migrated, expressed the adhesion protein, CD44, and that CD44"s main ligand, hyaluronic acid (HA) was robustly expressed in the inflammatory lesion. Hyaluronic Acid 134-149 CD44 molecule (Indian blood group) Rattus norvegicus 114-118 23280959-4 2013 We demonstrate that a large number of CG4 cells that had migrated, expressed the adhesion protein, CD44, and that CD44"s main ligand, hyaluronic acid (HA) was robustly expressed in the inflammatory lesion. Hyaluronic Acid 151-153 CD44 molecule (Indian blood group) Rattus norvegicus 114-118 24503496-1 2013 BACKGROUND/AIMS: The aim of our study was to reveal the role of CD44-Hyaluronic acid (HA) in the homing and improving renal function of systemically transplanted MSCs in chronic renal failure. Hyaluronic Acid 69-84 CD44 molecule (Indian blood group) Rattus norvegicus 64-68 21209591-5 2011 By mediating the attachment of dividing crypt cells to the basal lamina via hyaluronan, CD44 is considered to play a role in maintaining the intestinal villus integrity. Hyaluronic Acid 76-86 CD44 molecule (Indian blood group) Rattus norvegicus 88-92 21486216-3 2011 We provide in vitro and in vivo preclinical data on the antitumor efficacy of ONCOFID -S, a new bioconjugate of hyaluronic acid (HA) with SN-38 (the CPT11 active metabolite), that support the validity of the drug delivery strategy implying the use of HA as macromolecular carrier of antineoplastic drugs, an approach based on the over-expression of its target CD44 (the receptor for HA-mediated motility) in a wide variety of cancers. Hyaluronic Acid 112-127 CD44 molecule (Indian blood group) Rattus norvegicus 360-364 18289679-0 2008 Hyaluronic acid targets CD44 and inhibits FcepsilonRI signaling involving PKCdelta, Rac1, ROS, and MAPK to exert anti-allergic effect. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Rattus norvegicus 24-28 18556418-4 2008 Cell culture experiments were employed to determine whether hyaluronan can regulate cholangiocyte growth through interacting with adhesion molecule CD44. Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Rattus norvegicus 148-152 18556418-6 2008 CD44-positive biliary epithelia lining the intrahepatic bile ducts were geographically associated with extracellular hyaluronan accumulated in the portal tracts of the livers, suggesting a role for CD44 and hyaluronan in the development of biliary proliferation. Hyaluronic Acid 117-127 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 18556418-6 2008 CD44-positive biliary epithelia lining the intrahepatic bile ducts were geographically associated with extracellular hyaluronan accumulated in the portal tracts of the livers, suggesting a role for CD44 and hyaluronan in the development of biliary proliferation. Hyaluronic Acid 207-217 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 18556418-9 2008 CD44-hyaluronan interaction, by enhancing biliary proliferation, may play a pathogenic role in the development of cholestatic liver diseases. Hyaluronic Acid 5-15 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 18450824-4 2008 Taking advantage of the availability of in vitro models of human and rat blood-brain barrier developed in our laboratory and validated by us and others, we show here that soluble hyaluronic acid, the major ligand of the adhesion molecule CD44, as well as anti-CD44 blocking antibodies, largely prevents NPC adhesion to and migration across brain endothelium in inflammatory conditions. Hyaluronic Acid 179-194 CD44 molecule (Indian blood group) Rattus norvegicus 238-242 18450824-4 2008 Taking advantage of the availability of in vitro models of human and rat blood-brain barrier developed in our laboratory and validated by us and others, we show here that soluble hyaluronic acid, the major ligand of the adhesion molecule CD44, as well as anti-CD44 blocking antibodies, largely prevents NPC adhesion to and migration across brain endothelium in inflammatory conditions. Hyaluronic Acid 179-194 CD44 molecule (Indian blood group) Rattus norvegicus 260-264 18289679-15 2008 In conclusion, hyaluronic acid exerts negative effect on allergic inflammation by targeting CD44 and inhibiting FcepsilonRI signaling. Hyaluronic Acid 15-30 CD44 molecule (Indian blood group) Rattus norvegicus 92-96 16934786-0 2006 Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Rattus norvegicus 65-70 16934786-1 2006 OBJECTIVE: Hyaluronan (HA) is an important constituent of the extracellular matrix and is known to regulate cellular events through binding to CD44 and the receptor for HA-mediated motility (RHAMM). Hyaluronic Acid 11-21 CD44 molecule (Indian blood group) Rattus norvegicus 156-189 16934786-1 2006 OBJECTIVE: Hyaluronan (HA) is an important constituent of the extracellular matrix and is known to regulate cellular events through binding to CD44 and the receptor for HA-mediated motility (RHAMM). Hyaluronic Acid 11-21 CD44 molecule (Indian blood group) Rattus norvegicus 191-196 16934786-1 2006 OBJECTIVE: Hyaluronan (HA) is an important constituent of the extracellular matrix and is known to regulate cellular events through binding to CD44 and the receptor for HA-mediated motility (RHAMM). Hyaluronic Acid 11-21 CD44 molecule (Indian blood group) Rattus norvegicus 143-147 16700028-0 2006 Hyaluronan and its receptor CD44 in the heart of newborn and adult rats. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Rattus norvegicus 28-32 16673425-2 2006 CD44, a major cell adhesion molecule, plays crucial roles as an anchor between cells and extracellular matrices by binding hyaluronan (HA) for the development of organs or the metastasis of tumors. Hyaluronic Acid 123-133 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 15855623-3 2005 The biological functions of CD44 have been attributed to the generation of a functionally active hyaluronan-binding phenotype. Hyaluronic Acid 97-107 CD44 molecule (Indian blood group) Rattus norvegicus 28-32 15637344-1 2005 CD44 is a multifunctional adhesion molecule that binds to hyaluronan (HA), type I collagen, and fibronectin. Hyaluronic Acid 58-68 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 15947460-3 2005 The main ligand for CD44 is hyaluronan (HYA). Hyaluronic Acid 28-38 CD44 molecule (Indian blood group) Rattus norvegicus 20-24 15637344-1 2005 CD44 is a multifunctional adhesion molecule that binds to hyaluronan (HA), type I collagen, and fibronectin. Hyaluronic Acid 70-72 CD44 molecule (Indian blood group) Rattus norvegicus 0-4 14506240-4 2003 In stratified, organotypic cultures of the same cell line, both Has2 and Has3 with the hyaluronan receptor CD44 were up-regulated and hyaluronan accumulated in the epidermis, the spinous cell layer in particular. Hyaluronic Acid 87-97 CD44 molecule (Indian blood group) Rattus norvegicus 107-111 14638914-2 2003 Studies with renal tubular cells in culture indicate that hyaluronan (HA) and osteopontin (OPN) and their mutual cell surface receptor CD44 play an important role in calcium oxalate (CaOx) crystal binding during wound healing. Hyaluronic Acid 58-68 CD44 molecule (Indian blood group) Rattus norvegicus 135-139 11394655-1 2001 BACKGROUND: CD44 is a transmembrane glycoprotein known to bind hyaluronic acid (HA). Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Rattus norvegicus 12-16 11394655-1 2001 BACKGROUND: CD44 is a transmembrane glycoprotein known to bind hyaluronic acid (HA). Hyaluronic Acid 80-82 CD44 molecule (Indian blood group) Rattus norvegicus 12-16 10933610-8 2000 In summary, these findings demonstrate that CD44 expression by intestinal epithelial cells can be regulated by cytokines, yet their ability to bind hyaluronan and the isoform of the expressed CD44 remains unaltered. Hyaluronic Acid 148-158 CD44 molecule (Indian blood group) Rattus norvegicus 44-48 11222505-3 2001 In both cases, binding was blocked by a neutralizing anti-CD44 mAb or by the pretreatment of aggrecan with chondroitinase, but not hyaluronidase or keratanase, indicating that CD44 binds aggrecan in a manner dependent on CS side chains of aggrecan and that hyaluronic acid is not involved in the binding. Hyaluronic Acid 257-272 CD44 molecule (Indian blood group) Rattus norvegicus 176-180 11066094-8 2000 Cell surface detection for CD44 was co-localized with hyaluronan and proteoglycans at first appearance of disc formation in the nucleus pulposus. Hyaluronic Acid 54-64 CD44 molecule (Indian blood group) Rattus norvegicus 27-31 10840360-10 2000 CONCLUSIONS: This study shows that acute pancreatitis is associated with a strong but transient increase in interstitial hyaluronan and an infiltration of CD44-positive cells located mainly in the same region as the accumulated hyaluronan. Hyaluronic Acid 228-238 CD44 molecule (Indian blood group) Rattus norvegicus 155-159 10872376-1 1999 The multifunctional adhesion molecule CD44 is a major cell-surface receptor for hyaluronic acid (HUA). Hyaluronic Acid 80-95 CD44 molecule (Indian blood group) Rattus norvegicus 38-42 10708127-0 2000 Blocking of CD44-hyaluronic acid interaction prolongs rat allograft survival. Hyaluronic Acid 17-32 CD44 molecule (Indian blood group) Rattus norvegicus 12-16 10708127-3 2000 One of several proteins involved in this process is CD44, which is known to interact with endothelial hyaluronan (HA). Hyaluronic Acid 102-112 CD44 molecule (Indian blood group) Rattus norvegicus 52-56 10708127-3 2000 One of several proteins involved in this process is CD44, which is known to interact with endothelial hyaluronan (HA). Hyaluronic Acid 114-116 CD44 molecule (Indian blood group) Rattus norvegicus 52-56