PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15712181-0 2005 Versican in nonsmall cell lung cancer: relation to hyaluronan, clinicopathologic factors, and prognosis. Hyaluronic Acid 51-61 versican Homo sapiens 0-8 16159712-1 2006 Versican is a large (1-2 x 10(6) Da) chondroitin-sulfate proteoglycan that can form large aggregates by means of interaction with hyaluronan and also binds to a series of other extracellular matrix proteins, chemokines and cell-surface molecules. Hyaluronic Acid 130-140 versican Homo sapiens 0-8 15712181-6 2005 In the whole material, the significant relationship between high stromal staining of versican and that of hyaluronan was noticed (P = .001). Hyaluronic Acid 106-116 versican Homo sapiens 85-93 14977887-1 2004 To dissect the role of the globular domains of PGM/versican--a large hyaluronan binding proteoglycan (PG) enriched in tumor lesions--we have stably transduced a human leiomyosarcoma cell line with either the G1 or G3 domain of the PG and subsequently assayed the effect of this manipulation on several cellular processes in vitro and in vivo. Hyaluronic Acid 69-79 versican Homo sapiens 51-59 15142969-5 2004 Versican interacts with hyaluronan, a long chain glycosaminoglycan, to create expanded viscoelastic pericellular matrices that are required for arterial smooth muscle cell (ASMC) proliferation and migration. Hyaluronic Acid 24-34 versican Homo sapiens 0-8 12888576-0 2003 Distinct interaction of versican/PG-M with hyaluronan and link protein. Hyaluronic Acid 43-53 versican Homo sapiens 24-32 14506734-0 2003 Versican in epithelial ovarian cancer: relation to hyaluronan, clinicopathologic factors and prognosis. Hyaluronic Acid 51-61 versican Homo sapiens 0-8 14506734-8 2003 Versican is thus enriched in the malignant stroma surrounding and promoting the growth of ovarian cancer, probably acting with hyaluronan, and associates with unfavourable prognosis but does not constitute an independent indicator of patient survival. Hyaluronic Acid 127-137 versican Homo sapiens 0-8 12888576-5 2003 Overlay sensorgrams demonstrated that versican G1 or its B-B" segment forms a complex with both HA and LP. Hyaluronic Acid 96-98 versican Homo sapiens 38-46 8601689-1 1996 We studied the distribution of the large hyaluronan-binding proteoglycan versican (also known as PG-M) in human adult tissues using affinity-purified polyclonal antibodies that recognize the core protein of the prominent versican splice variants VO and V1. Hyaluronic Acid 41-51 versican Homo sapiens 73-81 10851128-0 2000 Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan. Hyaluronic Acid 74-84 versican Homo sapiens 112-120 9786264-7 1998 Two populations of smooth muscle cell versican were identified by means of CAPAGE-immunoblotting and by means of a novel affinity-blotting technique with biotinylated hyaluronan. Hyaluronic Acid 167-177 versican Homo sapiens 38-46 9088942-8 1997 The present results have shown that PG-M/versican was localized in the proliferating interstitial tissues, in particular in hyaluronic acid-rich portions, in association with carcinoma cell growth, and also that PG-M/versican accumulated in vascular and perivascular elastic tissues involved in carcinoma invasion. Hyaluronic Acid 124-139 versican Homo sapiens 41-49 8601689-1 1996 We studied the distribution of the large hyaluronan-binding proteoglycan versican (also known as PG-M) in human adult tissues using affinity-purified polyclonal antibodies that recognize the core protein of the prominent versican splice variants VO and V1. Hyaluronic Acid 41-51 versican Homo sapiens 221-229 1720020-10 1991 Bovine and human GHAP were demonstrated to bind specifically to hyaluronic acid (HA) with one protein molecule binding to an average 17 disaccharide repeating units. Hyaluronic Acid 64-79 versican Homo sapiens 17-21 7806529-2 1994 Inserted carboxyl-terminal of the hyaluronan-binding region, this domain adds another 987 amino acids to the original versican (V1) core protein giving rise to the large V0 isoform with 3396 amino acids and 17-23 putative glycosaminoglycan attachment sites. Hyaluronic Acid 34-44 versican Homo sapiens 118-126 7806529-9 1994 By expressing particular splice forms of versican, cells may control the hydration properties of their pericellular hyaluronan coat and thus could modulate interactions with the extracellular matrix or neighboring cells. Hyaluronic Acid 116-126 versican Homo sapiens 41-49 7921538-6 1994 This sequence covers three distinct domains of versican (hyaluronic acid binding domain, glycosaminoglycan attachment domain and protein binding domain) and demonstrates over 90% homology to the human versican sequence. Hyaluronic Acid 57-72 versican Homo sapiens 47-55 34626407-1 2022 Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA). Hyaluronic Acid 120-130 versican Homo sapiens 0-8 2469524-1 1989 A glial hyaluronate-binding protein (GHAP) was isolated from human brain white matter by affinity chromatography on immobilized hyaluronate. Hyaluronic Acid 8-19 versican Homo sapiens 37-41 2469524-7 1989 The findings suggest that the hyaluronate binding domains of such diverse proteins as brain GHAP and cartilage link protein are similar, probably due to the fact that hyaluronic acid is highly conserved in evolution. Hyaluronic Acid 30-41 versican Homo sapiens 92-96 2469524-7 1989 The findings suggest that the hyaluronate binding domains of such diverse proteins as brain GHAP and cartilage link protein are similar, probably due to the fact that hyaluronic acid is highly conserved in evolution. Hyaluronic Acid 167-182 versican Homo sapiens 92-96 30394708-2 2019 Versican, a large chondroitin sulfate proteoglycan that binds hyaluronan and forms large ECM aggregates, can influence fundamental physiological phenomena, such as cell proliferation, adhesion, and migration. Hyaluronic Acid 62-72 versican Homo sapiens 0-8 29410190-4 2019 Furthermore, hyaladherins like inter-alpha-inhibitor, tumor necrosis factor-stimulated gene 6, pentraxin 3 and versican are also induced and help form a dynamic hyaluronan matrix in injured lung. Hyaluronic Acid 161-171 versican Homo sapiens 111-119 24513039-8 2014 Versican, by binding to hyaluronan, influences T lymphocyte phenotypes and in part controls the ability of these cells to synthesize and secrete cytokines that influence the immune response. Hyaluronic Acid 24-34 versican Homo sapiens 0-8 29063508-4 2018 In this study, we measured the mRNA expression of hyaluronic acid-related proteins: hyaluronan synthase (HAS) 1-3, hyaluronidase-1, -2, and hyaluronic acid-binding protein (versican). Hyaluronic Acid 50-65 versican Homo sapiens 173-181 29310782-3 2018 Versican was first identified as a fibroblast proteoglycan and forms large multimolecular complexes with hyaluronan and other components of the provisional matrix during wound healing and inflammation. Hyaluronic Acid 105-115 versican Homo sapiens 0-8 28684419-2 2017 Versican is a large chondroitin sulfate-containing, hyaluronic acid-binding proteoglycan present in the extracellular matrix and in ocular vitreous body. Hyaluronic Acid 52-67 versican Homo sapiens 0-8 28684419-4 2017 Proteolysis of versican generates a hyaluronan-binding G1 domain. Hyaluronic Acid 36-46 versican Homo sapiens 15-23 28684419-7 2017 These data implicate versican G1 in enhancing adenoviral vector transgene expression in a hyaluronic acid-CD44 independent manner that is down-regulated by inhibitors of the JAK/STAT pathway and enhanced by inhibitors of the Src kinase pathway. Hyaluronic Acid 90-105 versican Homo sapiens 21-29 25320080-6 2014 Decreased versican expression was accompanied by slower rates of LMS cell proliferation and migration, increased adhesion, and decreased accumulation of the extracellular matrix macromolecule hyaluronan. Hyaluronic Acid 192-202 versican Homo sapiens 10-18 25320080-7 2014 Addition of purified versican to cells expressing versican siRNA restored cell proliferation to the level of LMS controls, increased the pericellular coat and the retention of hyaluronan, and decreased cell adhesion in a dose-dependent manner. Hyaluronic Acid 176-186 versican Homo sapiens 21-29 25320080-7 2014 Addition of purified versican to cells expressing versican siRNA restored cell proliferation to the level of LMS controls, increased the pericellular coat and the retention of hyaluronan, and decreased cell adhesion in a dose-dependent manner. Hyaluronic Acid 176-186 versican Homo sapiens 50-58 25320080-8 2014 The presence of versican was not only synergistic with hyaluronan in increasing cell proliferation, but the depletion of versican decreased hyaluronan synthase expression and decreased the retention of hyaluronan. Hyaluronic Acid 140-150 versican Homo sapiens 121-129 24444773-2 2014 Versican is a chondroitin-sulfate proteoglycan that forms highly hydrated complexes with hyaluronan and is widely distributed in the provisional matrix of mammalian embryos. Hyaluronic Acid 89-99 versican Homo sapiens 0-8 22155153-10 2012 Versican prevented T-cell binding to soluble hyaluronan, as well as the amoeboid shape change on hyaluronan-coated dishes and T-cell penetration of collagen gels. Hyaluronic Acid 45-55 versican Homo sapiens 0-8 22155153-10 2012 Versican prevented T-cell binding to soluble hyaluronan, as well as the amoeboid shape change on hyaluronan-coated dishes and T-cell penetration of collagen gels. Hyaluronic Acid 97-107 versican Homo sapiens 0-8 21505857-2 2012 Versican interacts with hyaluronan and fibrillin-1 at its amino terminus (G1) and carboxyl terminus (G3), respectively. Hyaluronic Acid 24-34 versican Homo sapiens 0-8 21136024-1 2011 Versican is a hyaluronan-binding, large extracellular matrix chondroitin sulfate proteoglycan whose expression is increased in malignant melanoma. Hyaluronic Acid 14-24 versican Homo sapiens 0-8 21136024-2 2011 Binding to hyaluronan allows versican to indirectly interact with the hyaluronan cell surface receptor CD44. Hyaluronic Acid 11-21 versican Homo sapiens 29-37 19581629-4 2009 However, a yellow colocalization signal required aggregation/overlap of several hyaluronan/versican strands and was more pronounced after acid-ethanol-formalin fixation. Hyaluronic Acid 80-90 versican Homo sapiens 91-99 21078678-1 2011 Versican is a hyaluronan-binding, extracellular chondroitin sulfate proteoglycan produced by several tumor types, including malignant melanoma, which exists as four different splice variants. Hyaluronic Acid 14-24 versican Homo sapiens 0-8 20164441-4 2010 Inter-alpha-trypsin inhibitor is also present in follicular fluid at least in species with large follicles, and inter-alpha-trypsin inhibitor and versican could additionally bind or cross-link with hyaluronan, resulting in the retention of these molecules within the follicular antrum. Hyaluronic Acid 198-208 versican Homo sapiens 146-154 17322391-8 2007 Administration of hyaluronan-versican aggregates, but not native hyaluronan alone, promoted stromal cell recruitment concurrently with the infiltration of endothelial cells. Hyaluronic Acid 18-28 versican Homo sapiens 29-37 17322391-8 2007 Administration of hyaluronan-versican aggregates, but not native hyaluronan alone, promoted stromal cell recruitment concurrently with the infiltration of endothelial cells. Hyaluronic Acid 65-75 versican Homo sapiens 29-37 17322391-9 2007 Taken together, these results suggest that hyaluronan overproduction accelerates tumor angiogenesis through stromal reaction, notably in the presence of versican. Hyaluronic Acid 43-53 versican Homo sapiens 153-161 17980161-1 2008 Versican, a large chondroitin sulphate proteoglycan and hyaluronan (HA), a non-sulphated glycosaminoglycan are major constituents of the pericellular matrix. Hyaluronic Acid 68-70 versican Homo sapiens 0-8 17363913-0 2007 Versican, a major hyaluronan-binding component in the dermis, loses its hyaluronan-binding ability in solar elastosis. Hyaluronic Acid 18-28 versican Homo sapiens 0-8 17363913-0 2007 Versican, a major hyaluronan-binding component in the dermis, loses its hyaluronan-binding ability in solar elastosis. Hyaluronic Acid 72-82 versican Homo sapiens 0-8 17363913-1 2007 Versican interacts with hyaluronan (HA) at its N-terminus and with fibrillin-1 at its C terminus. Hyaluronic Acid 24-34 versican Homo sapiens 0-8