PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18847363-0 2009 Biomimetic regeneration of elastin matrices using hyaluronan and copper ion cues. Hyaluronic Acid 50-60 elastin Homo sapiens 27-34 18847364-0 2009 Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells. Hyaluronic Acid 38-48 elastin Homo sapiens 83-90 18849207-3 2009 Our recent studies attest to the utility of hyaluronan (HA) oligomers for elastin synthesis and organization by adult vascular smooth muscle cells (SMCs), though the elastin matrix yields in these cases were quite low relative to total elastin produced. Hyaluronic Acid 44-54 elastin Homo sapiens 74-81 20709199-1 2011 Prior studies on two-dimensional cell cultures suggest that hyaluronic acid (HA) stimulates cell-mediated regeneration of extracellular matrix structures, specifically those containing elastin, though such biologic effects are dependent on HA fragment size. Hyaluronic Acid 60-75 elastin Homo sapiens 185-192 20709199-1 2011 Prior studies on two-dimensional cell cultures suggest that hyaluronic acid (HA) stimulates cell-mediated regeneration of extracellular matrix structures, specifically those containing elastin, though such biologic effects are dependent on HA fragment size. Hyaluronic Acid 77-79 elastin Homo sapiens 185-192 18847363-2 2009 We earlier showed that hyaluronan (HA) fragments greatly enhance tropo- and matrix-elastin synthesis by SMCs, although the yield of matrix elastin is low. Hyaluronic Acid 23-33 elastin Homo sapiens 83-90 18847363-2 2009 We earlier showed that hyaluronan (HA) fragments greatly enhance tropo- and matrix-elastin synthesis by SMCs, although the yield of matrix elastin is low. Hyaluronic Acid 35-37 elastin Homo sapiens 83-90 2127920-2 1990 On thin sections, elastin fibers showed antigenic sites for monoclonal antibodies recognizing the unsaturated units remaining after digestion of hyaluronic acid with Streptomyces hyaluronidase and after digestion of dermatan and chondroitin sulfates with chondroitinase ABC. Hyaluronic Acid 145-160 elastin Homo sapiens 18-25 10761634-12 1999 These studies indicate a protective effect of hyaluronan against elastase degradation of pulmonary elastin in vivo by both pancreatic and neutrophil elastases. Hyaluronic Acid 46-56 elastin Homo sapiens 99-106 10761634-13 1999 The anatomical studies further suggest a mechanism of protective coating of hyaluronan which may limit access to pulmonary elastin from neutrophils and alveolar macrophages. Hyaluronic Acid 76-86 elastin Homo sapiens 123-130 10761634-14 1999 Results also suggest that a reduction in pulmonary hyaluronan content increases the susceptibility of elastin to degradation by elastases. Hyaluronic Acid 51-61 elastin Homo sapiens 102-109 10761634-15 1999 These studies provide evidence for an antielastase effect of hyaluronan which is not dependent upon enzyme inhibition but on anatomical protection of pulmonary elastin by other mechanisms. Hyaluronic Acid 61-71 elastin Homo sapiens 160-167 30616332-1 2019 BACKGROUND: The oxidative stress, the UV radiations, the matrix metalloproteinases (MMPs) and the hyaluronidase enzyme play an extremly important role in skin aging processes, leading an increasing production of elastase, collagenase and hyaluronidase that brings to degradation of collagen, elastin and hyaluronic acid respectively. Hyaluronic Acid 304-319 elastin Homo sapiens 292-299 34048836-0 2021 Preparation of microfluidic-based pectin microparticles loaded carbon dots conjugated with BMP-2 embedded in gelatin-elastin-hyaluronic acid hydrogel scaffold for bone tissue engineering application. Hyaluronic Acid 125-140 elastin Homo sapiens 117-124 31284811-0 2019 Tuneable cellulose nanocrystal and tropoelastin-laden hyaluronic acid hydrogels. Hyaluronic Acid 54-69 elastin Homo sapiens 35-47 6456128-5 1981 It was also found that alpha-elastin methyl ester formed aggregates with hyaluronic acid, chondroitin sulfate, proteoglycan subunits and solubilized structural glycoproteins at room temperature and under conditions close to physiological ones. Hyaluronic Acid 73-88 elastin Homo sapiens 29-36 33906126-1 2021 INTRODUCTION: A previous 2-week clinical trial of aerosolized hyaluronan (HA) in COPD showed a rapid reduction in lung elastic fiber breakdown, as measured by sputum levels of the unique elastin crosslinks, desmosine and isodesmosine (DID). Hyaluronic Acid 62-72 elastin Homo sapiens 187-194 29519424-10 2018 In conclusion, we have characterized a biocompatible and bio-resorbable 3D-printed structured gelatin/elastin/sodium hyaluronate membrane with optimal biostability, mechanical strength and surgical handling characteristics in terms of suturability for potential application in GTR procedures. Hyaluronic Acid 110-128 elastin Homo sapiens 102-109 27149365-2 2016 A formula containing 7% HS and 0.1% hyaluronic acid (HA) is also available, basing its use on the protective effects of HA against elastin injury and on its greater ease of administration (i.e., the perceived acceptability of inhalation). Hyaluronic Acid 53-55 elastin Homo sapiens 131-138 29402544-10 2018 Many experimental studies support our observations, showing that cross-linked hyaluronic acid stimulates the production of several extra-cellular matrix components, including dermal collagen and elastin. Hyaluronic Acid 78-93 elastin Homo sapiens 195-202 29921376-1 2018 The aim of this screening study was to evaluate the efficacy of different proprietary mixtures of amino acid and hyaluronic acid (HA) in stimulating the production of extracellular matrix (ECM) components, particularly the neo-synthesis of elastin, and in promoting a more efficient deposition of elastic fibres (elastogenesis), while at the same time maintaining the stimulation of collagen. Hyaluronic Acid 130-132 elastin Homo sapiens 240-247 29461896-8 2018 Such an agent is hyaluronan aerosol, which is deficient in post mortem lungs with chronic obstructive pulmonary disease and has been shown to block elastin degradation, possibly by a barrier function. Hyaluronic Acid 17-27 elastin Homo sapiens 148-155 29075107-1 2017 A novel therapy for COPD involving the use of aerosolized hyaluronan (HA) was tested on a small cohort of COPD patients to determine both its safety and efficacy in reducing levels of desmosine and isodesmosine (DID), biomarkers for elastin degradation. Hyaluronic Acid 58-68 elastin Homo sapiens 233-240